Inhibition of peptidoglycan assembly complexes
The peptidoglycan (PGN) is an essential macromolecule of bacteria composed of a glycan moiety cross-linked by small stem peptides. The assembly of this macromolecule is achieved by protein complexes that involve synthetases, scaffolding proteins […]
Drug Discovery & Screening at Institut Pasteur
The Technological Targeted Action Drug Discovery and Screening (ATC-DDS) coordinates projects and collaborations at the Institut Pasteur Paris campus on therapeutic development. It raises awareness for DDS in basic research projects and stimulates intra-campus […]
2022A Defect in Lipoprotein Modification by Lgt Leads to Abnormal Morphology and Cell Death in Escherichia coli That Is Independent of Major Lipoprotein Lpp., J Bacteriol 2022 Sep; 204(9): e0016422.
2021Mode of action of lipoprotein modification enzymes-Novel antibacterial targets., Mol Microbiol 2021 03; 115(3): 356-365.
2020Click-Chemistry Based Fluorometric Assay for Apolipoprotein N-acyltransferase from Enzyme Characterization to High-Throughput Screening., J Vis Exp 2020 05; (159): .
2019A sensitive fluorescence-based assay to monitor enzymatic activity of the essential integral membrane protein Apolipoprotein N-acyltransferase (Lnt)., Sci Rep 2019 Nov; 9(1): 15978.
2017Structural insights into the mechanism of the membrane integral N-acyltransferase step in bacterial lipoprotein synthesis, Nat Commun 2017 Jul;8:15952.
2017Identification of Lipoproteins Using Globomycin and Radioactive Palmitate, Methods Mol. Biol. 2017;1615:75-80.
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