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© Matteo Bonazzi, Edith Gouin
Observation en immunofluorescence d'une cellule infectée par Listeria monocytogenes. En bleu: marquage des protéines de surface de Listeria qui permet de visualiser les bactéries. En rouge et vert: marquage de l'actine, une protéine qui forme le cytosquelette des cellules. Les Listeria utilisent l'actine cellulaire pour former des "comêtes" et se déplacer à l'intérieur des cellules qu'elles infectent. Cell infected by Listeria monocytogenes. The surface proteins (in blue) of Listeria enable us to view the bacteria. Actin, a constituent protein of cells, is shown in red and green.
Publication : The international journal of biochemistry & cell biology

The role of neutrophils in antibody-driven autoimmune cytopenias.

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in The international journal of biochemistry & cell biology - 01 Jun 2022

Krémer V, de Chaisemartin L, Jönsson F,

Link to Pubmed [PMID] – 35644471

Link to DOI – 10.1016/j.biocel.2022.106231

Int J Biochem Cell Biol 2022 Jun; 147(): 106231

Autoimmune cytopenias are a consequence of autoantibodies that target blood cell lineages and mark them for their accelerated destruction, mostly through phagocytosis by monocytes and macrophages and complement activation. Neutrophils, although equipped with Fc and complement receptors and effector mechanisms that are critical in other autoimmune conditions, remained long overlooked. Recent reports, however, propose a new and possibly critical role of neutrophils. In this review, we gathered available evidence on the contribution of neutrophils to the development, onset, and consequences of autoantibody-dependent cytopenias.

https://pubmed.ncbi.nlm.nih.gov/35644471