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  • Dual-education Student
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  • Honorary Professor
  • Lab assistant
  • Master Student
  • Non-permanent Researcher
  • Nursing Staff
  • Permanent Researcher
  • Pharmacist
  • PhD Student
  • Physician
  • Post-doc
  • Prize
  • Project Manager
  • Research Associate
  • Research Engineer
  • Retired scientist
  • Technician
  • Undergraduate Student
  • Veterinary
  • Visiting Scientist
  • Deputy Director of Center
  • Deputy Director of Department
  • Deputy Director of National Reference Center
  • Deputy Head of Facility
  • Director of Center
  • Director of Department
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Scientific Fields
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About

The Ecology and Evolution of Antibiotic Resistance (EERA) Unit aims at characterizing factors contributing to the emergence and the dissemination of antibiotic resistance clones in the hospital and in the community. Our research projects focus on Enterobacteriaceae resistant to carbapenems and/or expressing extended spectrum b-lactamases. These isolates represent today one of the most urgent public health threats because of their dramatic increase throughout the world. To address this issue, we are analyzing the evolutionary changes leading to the successful dissemination of specific clones, and the interaction of antibiotic resistant strains with the gut microbiota. We are also searching for the intrinsic factors of these clones contributing to resistance, increased fitness and to a greater capacity to disseminate in the human host and the in the environment. We are combining in silico studies based on comparative genomics, epidemiology, phylogenomics and mathematical modeling with functional studies of bacterial physiology and regulation. The Unit is located at the Institut Pasteur and at the Bicêtre Hospital, and is a joint structure between the Institut Pasteur, the Assistance Public Hôpitaux de Paris (APHP) and the University Paris Sud. Establishing a link between research and clinical cases is a key focus of our research.

Former Members

2000
2000
Name
Position
2016
2019
Violette Da Cunha
Post-doc
2016
2019
Elisabeth Sauvage
2016
2019
Pierre-Emmanuel Douarre
2016
2019
Alexandre Santos Almeida
2016
2019
Marie-Dominique Aytac
Administrative Staff
2016
2019
Vesna Mellon
Administrative Staff
2018
2019
Rafaël Patino-Navarrete
Post-doc
2018
2021
Adriana Chiarelli
PhD student
2020
2022
Virginie Guérin
Post-doc
2020
2024
Pengdbamba Dieudonné Zongo
PhD student

Projects

Project
Not started
2 Members

Whole genome sequencing and artificial intelligence to characterise and diagnose antibiotic resistance and capacity to escape treatment: Seq2Diag

Philippe Glaser (PI)

Project in collaborations with the following partners; – InBio Unit, Inria (Grégory Batt) -CNRS, Laboratoire de Recherche en Informatique, Université Paris-Saclay (Flora Jay) -INSERM, Délégation régionale Paris 11, U1184 RESIST Team (Thierry Naas) -CNRS, […]
Project
Ongoing
3 Members

High-throughput identification of antibiotic resistance progenitors across interconnected settings: PRE-EMPT

Philippe Glaser (PI)

Project with the following partners: -INSERM UMR1092, Université de Limoges (Marie-Cécile Ploy) -Anses, Unité Antibiorésistance et virulence bactériennes (Jean-Yves Madec) -INRAE, UMR-1282, Université de Tours (Sébastien Leclercq)
Project
Ongoing
34 Members

Welcome to the Nanopore User Group at Institut Pasteur webpage

Chiara Crestani (PI)

About the Nanopore User Group: The Nanopore User Group at Institut Pasteur was established in 2019 with the primary goal of fostering collaboration, sharing knowledge, and advancing the application of Oxford Nanopore Technologies (ONT) […]
Project
Ongoing
4 Members

Dynamics of Gut Microbiota

Philippe Glaser (PI)

Acquisition of antibiotic resistant bacteria and development of the gut microbiome in neonates in low-income countries. Antibiotic resistance represents a major health issue worldwide. The situation is particularly acute in low-income countries (LIC), due […]

Transversal Project

Drug Discovery & Screening at Institut Pasteur

The Technological Targeted Action Drug Discovery and Screening (ATC-DDS) coordinates projects and collaborations at the Institut Pasteur Paris campus on therapeutic development. It raises awareness for DDS in basic research projects and stimulates intra-campus […]

Emerging Infectious Diseases

Ever since its very early days, the Institut Pasteur has been committed to tackling emerging infections, and its work has left an extraordinary legacy. Many emerging infectious diseases are zoonoses, in which an animal […]

Antimicrobial resistance

Antimicrobial resistance is dramatically increasing worldwide and is becoming one of the most urgent public health threats. There is an urgent need for actions to reverse the curve of antimicrobial resistance dissemination and to […]

LabEx IBEID – Integrative Biology of Emerging Infectious Diseases

Presentation The aim of the Integrative Biology of Emerging Infectious Diseases (IBEID) project, coordinated by Professors Philippe Sansonetti and Pascale Cossart and currently coordinated by Carla Saleh and Philippe Bastin, is to develop a […]

Publications

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