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About

Cellular Plasticity and Disease Modelling Group studies the cause and consequence of cellular plasticity in ageing and cancer.

Cellular plasticity is the ability of a cell to acquire a new identity and to adopt an alternative fate when exposed to different conditions. Recent breakthrough in nuclear reprogramming highlights the amazing plasticity of differentiated cells, which has exciting implications for advances in disease modelling and regenerative medicine.

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Cellular plasticity is now emerging as an important process in normal physiology and in disease states, such as ageing and cancer. Our goal is to understand how aberrant cellular plasticity is induced during tumorigenesis and how to modulate cellular plasticity for regeneration especially in ageing related diseases.

Former Members

2000
2000
Name
Position
2015
2020
Sabela Bua Aguin
Post-doc
2015
2020
Olinda Alegria-Prevot
Research Engineer
2015
2020
Laure Bernard
PhD Student
2015
2020
Rana Salam
Undergraduate Student
2015
2020
Seynabou Diop
Undergraduate Student
2015
2020
Noah Dahan
Undergraduate Student
2015
2020
Khanh My Pham
Undergraduate Student
2015
2020
Aya El Hallak
Undergraduate Student
2015
2020
Elodie Da Costa
Undergraduate Student
2015
2020
Jholy De La Cruz
Undergraduate Student
2015
2020
Mariana Ponce de Leon Rodriguez
Graduate Student
2015
2020
Olga Estévez
Graduate Student
2015
2020
Cezarela Hoxha
Graduate Student
2015
2020
Mathieu von Joest
PhD Student
2015
2020
Edith Ollivier
Administrative Staff
2022
Corinne Billion
Administrative Staff
Quentin Naudin
Undergraduate Student
2021
Coralie Cazin
PhD Student
2020
Theo Herail
Internship Student
2022
Elsa Charifou
PhD Student
2022
Daryna Batechko
Intern
2023
Shaoxiang Wang
Graduate Student
Show all

Projects

Project
Ongoing
16 Members

Organ-on-Chip Center

Samy Gobaa (PI)

What’s best to study humans and their infectious deseases than Human emulation system ? It’s now possible at Pasteur to develop real Organs-on-chips with cells from different sources, patient derived or cell line. At […]
Project
Ongoing
4 Members

Cellular plasticity and Ageing

Han Li (PI)

Ageing is associated with losing normal cellular plasticity (regeneration capacity) while acquiring abnormal cellular dys-plasticity (cancer). Cellular reprogramming is associated with a gain in the potential for differentiation and self-renewal. Could common pathways be […]
Project
ongoing
1 Member

Cellular plasticity and Cancer

Han Li (PI)

Aberrant cellular plasticity (“dys-plasticity”) could occur in vivo, which contributes significantly to disease development, especially in cancer. Recently, we showed p27-/- cells are dysplastic due to the derepression of Sox2, an essential pluripotency gene. […]

Transversal Project

The IP Stem Cell Initiative

The Stem Cell Concept – Constructing, Deconstructing and Reconstructing Tissues for organismal health Human biology and molecular medicine are rapidly becoming data-rich fields that are fueled in part by large-scale longitudinal studies of patients […]

Drug Discovery & Screening at Institut Pasteur

The Technological Targeted Action Drug Discovery and Screening (ATC-DDS) coordinates projects and collaborations at the Institut Pasteur Paris campus on therapeutic development. It raises awareness for DDS in basic research projects and stimulates intra-campus […]

Cancer Initiative

With more than 19.3 million new cases in 2020 worldwide, including nearly 400,000 in France, cancer is a common disease that affects or will affect us all one day, directly or indirectly. It is […]

Ageing & Longevity

According to the WHO, the global percentage of people aged of more than 60 years will double from 11 to 22% between 2000 and 2050. Nowadays most of the elderly die of non-transmissible diseases […]

LabEx Revive – Regenerative biology & medicine

Rationale and Objectives of Revive Consortium Major advancements in stem cell biology have paved the way for concerted research activities on the fundamental biology of stem cells and their applications in the clinic. The […]

Fundings

Featured publications

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Contact

Phone: Email: Address 25-28 Rue du Docteur Roux 75015, Paris France