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  • nrc
  • whocc
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  • tool
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  • Administrative Staff
  • Associate Professor
  • Clinical Research Assistant
  • Full Professor
  • Graduate Student
  • Lab assistant
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  • Pharmacist
  • PhD Student
  • Physician
  • Post-doc
  • Project Manager
  • Research Engineer
  • Retired scientist
  • Technician
  • Undergraduate Student
  • Visiting Scientist
  • Deputy Director of Center
  • Deputy Director of Department
  • Deputy Director of National Reference Center
  • Director of Center
  • Director of Department
  • Director of Institute
  • Director of National Reference Center
  • Group Leader
  • Head of Facility
  • Head of Structure
  • Honorary President of the Departement
  • Labex Coordinator
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Scientific Fields
Diseases
Organisms
Applications
Technique
Starting Date
09
Jun 2015
Status
Ongoing
Members
3
Structures
3

About

Ageing is associated with losing normal cellular plasticity (regeneration capacity) while acquiring abnormal cellular dys-plasticity (cancer). Cellular reprogramming is associated with a gain in the potential for differentiation and self-renewal. Could common pathways be controlling these two seemingly opposite processes? Previously, we reported that ageing has a negative effect on reprogramming and this is partially due to an age-dependent increase of the Ink4/Arf locus. However, the conceptual parallels between reprogramming and ageing are largely unexplored. We aim to harness the power of this in vitro system to elucidate organismal ageing by identifying molecular determinants of ageing.

3.png
Old cells reprogram less efficient than young cells

Recently, reprogramming has been achieved in vivo (Abad, et al., Nature 2013). This breakthrough brought us one step closer to tissue regeneration in situ. We established this mouse model in the lab. We will use this powerful new tool to understand the impact of ageing on cellular plasticity, moreover to explore how to induce proper cellular plasticity for regeneration especially in ageing related diseases.

 

4.png
In vivo reprogramming mouse model