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© Pierre Gounon
Culture de cellules infectées par le virus Ebola, virus isolé sur un malade de Côte d'Ivoire par Leguenno en 1995. Virus de la famille des Filoviridae genre Filovirus. Réservoir naturel et mode de transmission inconnus. Infections secondaires par contact direct avec sang contaminé ou sécrétions corporelles. Mortalité dans 50 à 90% des cas. Soudan, République Démocratique du Congo, Côte d'Ivoire (Grossissement X 40000).
Publication : Emerging microbes & infections

Lassa fever in Benin: description of the 2014 and 2016 epidemics and genetic characterization of a new Lassa virus.

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Emerging microbes & infections - 01 Dec 2020

Yadouleton A, Picard C, Rieger T, Loko F, Cadar D, Kouthon EC, Job EO, Bankolé H, Oestereich L, Gbaguidi F, Pahlman M, Becker-Ziaja B, Journeaux A, Pannetier D, Mély S, Mundweiler S, Thomas D, Kohossi L, Saizonou R, Kakaï CG, Da Silva M, Kossoubedie S, Kakonku AL, M'Pelé P, Gunther S, Baize S, Fichet-Calvet E,

Link to Pubmed [PMID] – 32723007

Link to DOI – 10.1080/22221751.2020.1796528

Emerg Microbes Infect 2020 Dec; 9(1): 1761-1770

We report two outbreaks of Lassa fever that occurred in Benin in 2014 and 2016 with 20 confirmed cases and 50% (10/20) mortality. Benin was not previously considered to be an endemic country for Lassa fever, resulting in a delay to diagnose the disease and its human transmission. Molecular investigations showed the viral genomes to be similar to that of the Togo strain, which is genetically very different from other known strains and confirms the existence of a new lineage. Endemic circulation of Lassa virus in a new territory and the genetic diversity thus confirm that this virus represents a growing threat for West African people. Given the divergence of the Benin strain from the prototypic Josiah Sierra Leone strain frequently used to generate vaccine candidates, the efficacy of vaccine candidates should also be demonstrated with this strain.

https://pubmed.ncbi.nlm.nih.gov/32723007