Our work is focused on understanding host-parasite interactions during the pre-erythrocytic and pre-symptomatic phase of malaria. We leverage rodent models, hepatocyte culture systems, and single-cell-based approaches to unravel the mechanisms of dormancy, relapse, and transmission.
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About
Members
Groups
Group
Group: Humanized mice and in vivo analysis of human Plasmodium infections
Sylvie Garcia
Former Members
2000
2000
Name
Position
2019
2022
Sabine Thiberge
Research Engineer
2020
2020
Kohilavathani Chivaloganadan
Sorbonne M2 Student
2022
2022
Emma Colard Itté
Sorbonne M2 Student
2022
2023
Julie De Oliveira
Research Engineer
2023
2023
Anisha Jain
MIT-France Student
2023
2023
Vitória Baptista
Erasmus+ Student
2024
2024
Sage V Kang
UC Berkely Student
Jobs
Transversal Project
Fundings
Featured publications
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2024Autonomous circadian rhythms in the human hepatocyte regulate hepatic drug metabolism and inflammatory responses., Sci Adv 2024 Apr; 10(17): eadm9281.
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2023Hemisynthetic alkaloids derived from trilobine are antimalarials with sustained activity in multidrug-resistant Plasmodium falciparum., iScience 2023 Feb; 26(2): 105940.
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2022Repurposing of Plasmodium falciparum var genes beyond the blood stage., Curr Opin Microbiol 2022 Sep; 70(): 102207.
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2022Humanized mice for investigating sustained Plasmodium vivax blood-stage infections and transmission., Nat Commun 2022 Jul; 13(1): 4123.
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2022A single-cell liver atlas of Plasmodium vivax infection., Cell Host Microbe 2022 07; 30(7): 1048-1060.e5.
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2022Single-cell views of the Plasmodium life cycle., Trends Parasitol 2022 Jun; (): .
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2019Targeting liver stage malaria with metformin., JCI Insight 2019 12; 4(24): .
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2019Improving Drug Discovery by Nucleic Acid Delivery in Engineered Human Microlivers., Cell Metab 2019 03; 29(3): 727-735.e3.
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2018In Vitro Culture, Drug Sensitivity, and Transcriptome of Plasmodium Vivax Hypnozoites., Cell Host Microbe 2018 Mar; 23(3): 395-406.e4.
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2018Engineered Livers for Infectious Diseases., Cell Mol Gastroenterol Hepatol 2018 ; 5(2): 131-144.
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2017Nutrient sensing modulates malaria parasite virulence., Nature 2017 07; 547(7662): 213-216.
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2016Host AMPK Is a Modulator of Plasmodium Liver Infection., Cell Rep 2016 09; 16(10): 2539-2545.
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Contact
Email: liliana.mancio@pasteur.fr Address: 28 Rue du Dr Roux, 75015 Paris, France