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About

Our work is focused on understanding host-parasite interactions during the pre-erythrocytic and pre-symptomatic phase of malaria. We leverage rodent models, hepatocyte culture systems, and single-cell-based approaches to unravel the mechanisms of dormancy, relapse, and transmission.

Former Members

2000
2000
Name
Position
2019
2022
Sabine Thiberge
Research Engineer
2020
2020
Kohilavathani Chivaloganadan
Sorbonne M2 Student
2022
2022
Emma Colard Itté
Sorbonne M2 Student
2022
2023
Julie De Oliveira
Research Engineer
2023
2023
Anisha Jain
MIT-France Student
2023
2023
Vitória Baptista
Erasmus+ Student
2024
2024
Sage V Kang
UC Berkely Student

Projects

We seek to understand whether malaria-causing Plasmodium parasites i) use sensing mechanisms to select the hepatocyte where its replication will unfold and/or ii) promote host metabolic reprogramming upon invasion of the host cell. To address these questions, we are employing advanced single-cell live imaging approaches and bioengineered in vitro human liver systems.

Project
Ongoing
5 Members

Identification de médicaments pour le traitement du paludisme à tous les stades de la maladie : PANDORA (2024-070)

Liliana Mancio Silva (PI)

Sorry, this entry is only available in FR.

Fundings

Featured publications

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Transversal Project

Drug Discovery & Screening at Institut Pasteur

The Technological Targeted Action Drug Discovery and Screening (ATC-DDS) coordinates projects and collaborations at the Institut Pasteur Paris campus on therapeutic development. It raises awareness for DDS in basic research projects and stimulates intra-campus […]

Center for Vaccinology and Immunotherapy (CVI)

Vaccines and immunotherapies have had a major positive impact on public health world-wide through disease prevention and treatment that can be measured in millions of lives saved. Despite the successes, we still face major […]

Antimicrobial resistance

Antimicrobial resistance is dramatically increasing worldwide and is becoming one of the most urgent public health threats. There is an urgent need for actions to reverse the curve of antimicrobial resistance dissemination and to […]

Contact

Email: liliana.mancio@pasteur.fr  Address: 28 Rue du Dr Roux, 75015 Paris, France