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© Liliana Mancio, Institut Pasteur
Primary human hepatocytes co-cultured with parenchymal cells at 6 days post-seeding. The expression of human CD81 is depicted in pink
Publication : Current opinion in microbiology

Repurposing of Plasmodium falciparum var genes beyond the blood stage.

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Current opinion in microbiology - 29 Sep 2022

Real E, Nardella F, Scherf A, Mancio-Silva L,

Link to Pubmed [PMID] – 36183663

Link to DOI – S1369-5274(22)00091-110.1016/j.mib.2022.102207

Curr Opin Microbiol 2022 Sep; 70(): 102207

A commonly observed survival strategy in protozoan parasites is the sequential expression of clonally variant-surface antigens to avoid elimination by the host’s immune response. In malaria-causing P. falciparum, the immunovariant erythrocyte-membrane protein-1 (PfEMP1) adhesin family, encoded by var genes, is responsible for both antigenic variation and cytoadherence of infected erythrocytes to the microvasculature. Until recently, the biological function of these variant genes was believed to be restricted to intraerythrocytic developmental stages. With the advent of new technologies, var gene expression has been confirmed in transmission and pre-erythrocytic stages. Here, we discuss how repurposing of var gene expression beyond chronic blood-stage infection may be critical for successful transmission.

https://pubmed.ncbi.nlm.nih.gov/36183663