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  • Project Manager
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  • Research Engineer
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  • Technician
  • Undergraduate Student
  • Veterinary
  • Visiting Scientist
  • Deputy Director of Center
  • Deputy Director of Department
  • Deputy Director of National Reference Center
  • Deputy Head of Facility
  • Director of Center
  • Director of Department
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© Research
Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Trends in parasitology - 04 Jun 2022

Real E, Mancio-Silva L,

Link to Pubmed [PMID] – 35672200

Link to DOI – S1471-4922(22)00112-X10.1016/j.pt.2022.05.009

Trends Parasitol 2022 Jun; ():

Malaria-causing Plasmodium parasites undergo multiple phenotypic transitions as they cycle between diverse niches in the mammalian and mosquito hosts. Recent applications of single-cell technologies to Plasmodium have enabled the systematic investigation of the distinct stages across the life cycle. Most single-cell data have focused on the parasite exclusively, but a few studies have started to profile both parasite and host cells to shed light on the heterogeneity of cell states that underpin host-parasite interactions. In this opinion article, we highlight how atlasing initiatives are starting to be used to infer functional interactions between parasite and host and could be a powerful tool in drug discovery and vaccine development.

https://pubmed.ncbi.nlm.nih.gov/35672200