I have a long standing interest in malaria research, including understanding the malaria parasite biology and the interventions needed to control malaria disease. Currently, I am leveraging rodent malaria models, hepatocyte culture systems, and live imaging approaches to study host-parasite metabolic interactions.
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Timeline
CV
RESEARCH EXPERIENCE
2019 – … Research Associate at Institut National de la Santé et de la Recherche Médicale (INSERM)
2016 – 2019 Research Scientist at Massachusetts Institute of Technology (USA) with Prof. S. Bhatia
2016 – 2019 Visiting Scientist at Mahidol University (Thailand) with Dr. J. Sattabongkot
2013, 2014 Visiting Scientist at Wellcome Sanger Institute (UK) with Dr. Oliver Billker
2010 – 2016 Postdoctoral fellow at Instituto de Medicina Molecular (Portugal) with Prof. M. Mota
EDUCATION
2009 Ph.D. Institut Pasteur Paris / Universidade do Porto
2003 Pharm.D. Universidade do Porto (Portugal)
Publications
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2020Expansion, in vivo-ex vivo cycling, and genetic manipulation of primary human hepatocytes, Proc. Natl. Acad. Sci. U.S.A. 2020 Jan;.
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2019Targeting liver stage malaria with metformin, JCI Insight 2019 Dec;4(24).
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2019γδ-T cells promote IFN-γ-dependent pathogenesis upon liver-stage infection, Proc. Natl. Acad. Sci. U.S.A. 2019 May;116(20):9979-9988.
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2019Steroid Hormone Function Controls Non-competitive Plasmodium Development in Anopheles, Cell 2019 Apr;177(2):315-325.e14.
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2019Improving Drug Discovery by Nucleic Acid Delivery in Engineered Human Microlivers, Cell Metab. 2019 Mar;29(3):727-735.e3.
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2019Estrogen Activation of G-Protein-Coupled Estrogen Receptor 1 Regulates Phosphoinositide 3-Kinase and mTOR Signaling to Promote Liver Growth in Zebrafish and Proliferation of Human Hepatocytes, Gastroenterology 2019 05;156(6):1788-1804.e13.
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2018In Vitro Culture, Drug Sensitivity, and Transcriptome of Plasmodium Vivax Hypnozoites, Cell Host Microbe 2018 Mar;23(3):395-406.e4.
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2017Engineered Livers for Infectious Diseases, Cell Mol Gastroenterol Hepatol 2018;5(2):131-144.
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2017Plasmodium UIS3 sequesters host LC3 to avoid elimination by autophagy in hepatocytes, Nat Microbiol 2018 Jan;3(1):17-25.
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2017Nutrient sensing modulates malaria parasite virulence, Nature 2017 07;547(7662):213-216.
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