I have a long standing interest in malaria research, including understanding the malaria parasite biology and the interventions needed to control malaria disease. Currently, I am leveraging rodent malaria models, hepatocyte culture systems, and live imaging approaches to study host-parasite metabolic interactions.
Host parasite metabolic interactions
In this research project, we seek to understand whether malaria-causing Plasmodium parasites i) use sensing mechanisms to select the hepatocyte where its replication will unfold and/or ii) promote host metabolic reprogramming upon invasion of […]
2019 – … Research Associate at Institut National de la Santé et de la Recherche Médicale (INSERM)
2016 – 2019 Research Scientist at Massachusetts Institute of Technology (USA) with Prof. S. Bhatia
2016 – 2019 Visiting Scientist at Mahidol University (Thailand) with Dr. J. Sattabongkot
2013, 2014 Visiting Scientist at Wellcome Sanger Institute (UK) with Dr. Oliver Billker
2010 – 2016 Postdoctoral fellow at Instituto de Medicina Molecular (Portugal) with Prof. M. Mota
2009 Ph.D. Institut Pasteur Paris / Universidade do Porto
2003 Pharm.D. Universidade do Porto (Portugal)
2022A single-cell liver atlas of Plasmodium vivax infection., Cell Host Microbe 2022 Apr; (): .
2021Linking microbiota composition with antimalarial antibody response., Trends Parasitol 2021 10; 37(10): 853-855.
2020Expansion, in vivo-ex vivo cycling, and genetic manipulation of primary human hepatocytes., Proc Natl Acad Sci U S A 2020 01; 117(3): 1678-1688.
2019Targeting liver stage malaria with metformin., JCI Insight 2019 12; 4(24): .
2019γδ-T cells promote IFN-γ-dependent Plasmodium pathogenesis upon liver-stage infection., Proc Natl Acad Sci U S A 2019 05; 116(20): 9979-9988.
2019Estrogen Activation of G-Protein-Coupled Estrogen Receptor 1 Regulates Phosphoinositide 3-Kinase and mTOR Signaling to Promote Liver Growth in Zebrafish and Proliferation of Human Hepatocytes., Gastroenterology 2019 05; 156(6): 1788-1804.e13.
2019Steroid Hormone Function Controls Non-competitive Plasmodium Development in Anopheles., Cell 2019 04; 177(2): 315-325.e14.
2019Improving Drug Discovery by Nucleic Acid Delivery in Engineered Human Microlivers., Cell Metab 2019 03; 29(3): 727-735.e3.
2018In Vitro Culture, Drug Sensitivity, and Transcriptome of Plasmodium Vivax Hypnozoites., Cell Host Microbe 2018 Mar; 23(3): 395-406.e4.
2018Plasmodium UIS3 sequesters host LC3 to avoid elimination by autophagy in hepatocytes., Nat Microbiol 2018 Jan; 3(1): 17-25.
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