I have a long-standing interest in malaria research, including understanding the malaria parasite biology and the interventions needed to control malaria disease and transmission. Malaria-causing Plasmodium parasites cycle between diverse niches in the mammalian and mosquito hosts, where they undergo multiple phenotypic transitions and massive replication. My research work encompasses the transition from the mosquito to the liver, as well as the liver- and blood-stage replication in the mammalian host.
Host parasite metabolic interactions
In this research project, we seek to understand whether malaria-causing Plasmodium parasites i) use sensing mechanisms to select the hepatocyte where its replication will unfold and/or ii) promote host metabolic reprogramming upon invasion of […]
Group Leader at Institut Pasteur Paris (since 2020)
Permanent Researcher at Inserm (since 2019)
Research Scientist at Massachusetts Institute of Technology, USA (2016 – 2019)
Postdoctoral fellow at Instituto de Medicina Molecular, Portugal (2010 – 2016)
Doctoral fellow at Institut Pasteur Paris, France (2004 – 2009)
PharmD Universidade do Porto, Portugal (1997 – 2003)
2023Hemisynthetic alkaloids derived from trilobine are antimalarials with sustained activity in multidrug-resistant Plasmodium falciparum., iScience 2023 Feb; 26(2): 105940.
2022Repurposing of Plasmodium falciparum var genes beyond the blood stage., Curr Opin Microbiol 2022 Sep; 70(): 102207.
2022Ebola virus infection induces a delayed type I IFN response in bystander cells and the shutdown of key liver genes in human iPSC-derived hepatocytes., Stem Cell Reports 2022 Aug; (): .
2022Humanized mice for investigating sustained Plasmodium vivax blood-stage infections and transmission., Nat Commun 2022 Jul; 13(1): 4123.
2022A single-cell liver atlas of Plasmodium vivax infection., Cell Host Microbe 2022 07; 30(7): 1048-1060.e5.
2022Single-cell views of the Plasmodium life cycle., Trends Parasitol 2022 Jun; (): .
2021Linking microbiota composition with antimalarial antibody response., Trends Parasitol 2021 10; 37(10): 853-855.
2020Expansion, in vivo-ex vivo cycling, and genetic manipulation of primary human hepatocytes., Proc Natl Acad Sci U S A 2020 01; 117(3): 1678-1688.
2019Targeting liver stage malaria with metformin., JCI Insight 2019 12; 4(24): .
2019γδ-T cells promote IFN-γ-dependent Plasmodium pathogenesis upon liver-stage infection., Proc Natl Acad Sci U S A 2019 05; 116(20): 9979-9988.
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