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© Artur Scherf
Scanning Electron Microscopy of Red Blood Cell infected by Plasmodium falciparum.
Publication : Cellular and molecular gastroenterology and hepatology

Engineered Livers for Infectious Diseases

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Cellular and molecular gastroenterology and hepatology - 22 Nov 2017

Gural N, Mancio-Silva L, He J, Bhatia SN

Link to Pubmed [PMID] – 29322086

Cell Mol Gastroenterol Hepatol 2018;5(2):131-144

Engineered liver systems come in a variety of platform models, from 2-dimensional cocultures of primary human hepatocytes and stem cell-derived progeny, to 3-dimensional organoids and humanized mice. Because of the species-specificity of many human hepatropic pathogens, these engineered systems have been essential tools for biologic discovery and therapeutic agent development in the context of liver-dependent infectious diseases. Although improvement of existing models is always beneficial, and the addition of a robust immune component is a particular need, at present, considerable progress has been made using this combination of research platforms. We highlight advances in the study of hepatitis B and C viruses and malaria-causing and  parasites, and underscore the importance of pairing the most appropriate model system and readout modality with the particular experimental question at hand, without always requiring a platform that recapitulates human physiology in its entirety.

https://www.ncbi.nlm.nih.gov/pubmed/29322086