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© Artur Scherf
Scanning Electron Microscopy of Red Blood Cell infected by Plasmodium falciparum.
Publication : Cellular and molecular gastroenterology and hepatology

Engineered Livers for Infectious Diseases.

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Cellular and molecular gastroenterology and hepatology - 01 Jan 2018

Gural N, Mancio-Silva L, He J, Bhatia SN,

Link to Pubmed [PMID] – 29322086

Link to DOI – 10.1016/j.jcmgh.2017.11.005

Cell Mol Gastroenterol Hepatol 2018 ; 5(2): 131-144

Engineered liver systems come in a variety of platform models, from 2-dimensional cocultures of primary human hepatocytes and stem cell-derived progeny, to 3-dimensional organoids and humanized mice. Because of the species-specificity of many human hepatropic pathogens, these engineered systems have been essential tools for biologic discovery and therapeutic agent development in the context of liver-dependent infectious diseases. Although improvement of existing models is always beneficial, and the addition of a robust immune component is a particular need, at present, considerable progress has been made using this combination of research platforms. We highlight advances in the study of hepatitis B and C viruses and malaria-causing Plasmodium falciparum and Plasmodium vivax parasites, and underscore the importance of pairing the most appropriate model system and readout modality with the particular experimental question at hand, without always requiring a platform that recapitulates human physiology in its entirety.

https://pubmed.ncbi.nlm.nih.gov/29322086