Milieu Intérieur: Deconvolution of the healthy immune response
Systems approaches for the study of immune signaling pathways have been traditionally based on selected purified cell types or cultured cell lines. However, in vivo responses involve the coordinated action of multiple cell types, […]
Functional immune response to Mycobacteria tuberculosis derived antigen
The objective of our project is to establish feasibility for a new generation of in vitro diagnostic (IVDs) tools, applied to proof-of-concept studies in Mycobacterium tuberculosis (MTB) infected persons and patients with TB disease. […]
2018T-cell biomarkers for diagnosis of tuberculosis: candidate evaluation by a simple whole blood assay for clinical translation, Eur. Respir. J. 2018 Mar;51(3).
2018Natural variation in the parameters of innate immune cells is preferentially driven by genetic factors, Nat. Immunol. 2018 Mar;19(3):302-314.
2017Distinctive roles of age, sex, and genetics in shaping transcriptional variation of human immune responses to microbial challenges, Proc. Natl. Acad. Sci. U.S.A. 2018 01;115(3):E488-E497.
2017Standardized whole blood stimulation improves immunomonitoring of induced immune responses in multi-center study, Clin. Immunol. 2017 Sep;.
2016Standardized Whole-Blood Transcriptional Profiling Enables the Deconvolution of Complex Induced Immune Responses, DOI: http://dx.doi.org/10.1016/j.celrep.2016.08.011 show.
2015The Milieu Intérieur study – an integrative approach for study of human immunological variance, Clin. Immunol. 2015 Apr;157(2):277-93.
2014Functional analysis via standardized whole-blood stimulation systems defines the boundaries of a healthy immune response to complex stimuli, Immunity 2014 Mar;40(3):436-50.