Single cell gene expression and beyond
Course Overview The course aims at providing theoretical and hands-on training for all steps of high-throughput single cell profiling, from single-cell sample and library preparation to data analysis, using state-of-the-art technological solutions. Program This […]
Dissemination of tumor cells and metastasis represent the major cause of death in cancer patients. More than 5% of patients show liver metastases at the time of primary cancer diagnosis, a feature associated with […]
Single cell projects
Numerous research groups from the Institut Pasteur, from the Pasteur International Network (RIIP) and from various external academic and clinical institutions benefit from the single cell resources of the Institut Pasteur. The groups with […]
2023Dissecting human population variation in single-cell responses to SARS-CoV-2, Nature, 2023, 53 (8), pp.e2250307. ⟨10.1038/s41586-023-06422-9⟩.
2023Single-cell transcriptomic profiling of the mouse cochlea: An atlas for targeted therapies., Proc Natl Acad Sci U S A 2023 Jun; 120(26): e2221744120.
2022Low CCR5 expression protects HIV-specific CD4+ T cells of elite controllers from viral entry., Nat Commun 2022 Jan; 13(1): 521.
2021Single-Cell and Bulk RNA-Sequencing Reveal Differences in Monocyte Susceptibility to Influenza A Virus Infection Between Africans and Europeans., Front Immunol 2021 ; 12(): 768189.
2018Natural variation in the parameters of innate immune cells is preferentially driven by genetic factors., Nat Immunol 2018 Mar; 19(3): 302-314.
2016Standardized Whole-Blood Transcriptional Profiling Enables the Deconvolution of Complex Induced Immune Responses, DOI: http://dx.doi.org/10.1016/j.celrep.2016.08.011 show.
2016Protein biomarkers discriminate Leishmania major-infected and non-infected individuals in areas endemic for cutaneous leishmaniasis, BMC Infect. Dis. 2016;16:138.
2015Automated flow cytometric analysis across large numbers of samples and cell types., Clin Immunol 2015 Apr; 157(2): 249-60.
2014Functional analysis via standardized whole-blood stimulation systems defines the boundaries of a healthy immune response to complex stimuli., Immunity, 2014, 40 (3), pp.436-50. ⟨10.1016/j.immuni.2014.03.002⟩.