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Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Scientific reports - 18 May 2017

Lago M, Monteil V, Douche T, Guglielmini J, Criscuolo A, Maufrais C, Matondo M, Norel F

Link to Pubmed [PMID] – 28522802

Sci Rep 2017 May;7(1):2127

The RpoS/σ sigma subunit of RNA polymerase is the master regulator of the general stress response in many Gram-negative bacteria. Extensive studies have been conducted on σ-regulated gene expression at the transcriptional level. In contrast, very limited information regarding the impact of σ on global protein production is available. In this study, we used a mass spectrometry-based proteomics approach to explore the wide σ-dependent proteome of the human pathogen Salmonella enterica serovar Typhimurium. Our present goals were twofold: (1) to survey the protein changes associated with the ΔrpoS mutation and (2) to assess the coding capacity of σ-dependent small RNAs. Our proteomics data, and complementary assays, unravelled the large impact of σ on the Salmonella proteome, and validated expression and σ regulation of twenty uncharacterized small proteins of 27 to 96 amino acids. Furthermore, a large number of genes regulated at the protein level only were identified, suggesting that post-transcriptional regulation is an important component of the σ response. Novel aspects of σ in the control of important catabolic pathways such as myo-inositol, L-fucose, propanediol, and ethanolamine were illuminated by this work, providing new insights into the physiological remodelling involved in bacterial adaptation to a non-actively growing state.

https://www.ncbi.nlm.nih.gov/pubmed/28522802