Nathalie Aulner received her PhD in Molecular Biology from the University Paul Sabatier (Toulouse, France) after completing an engineer degree in Biochemistry and Biotechnology at the Institut National des Sciences Appliquées (Toulouse). She joined the Institut Pasteur in 2009 to take charge of the High Content Analysis efforts in the Imagopole-CiTech led by Pr. S. Shorte. Her areas of interest encompass the challenges of applying high content analysis to the study of infectious diseases, developing assays to achieve physiologically and clinically relevant conditions, live cell imaging and applying robust statistical methodologies. She is as well implicated in the facility training programs in microscopy and is the point of contact for all Health and Safety matters in the platform. Before joining the Institut Pasteur, she worked for several years in the United States, including as an associate research scientist at the Columbia University Screening Center (New York) led by Dr J.E. Rothman and in the Functional Proteomic Project (joined ventures between the Memorial Sloan Kettering Cancer Center in New York and Amersham biosciences to set up a siRNA phenotypic screening facility).
Fluorescence Microscopy Workshop III/on cutting-edge technologies
Fluorescence Microscopy Workshop III/on cutting-technologies
Rémi Galland, University of Bordeaux, Interdisciplinary Institute for Neurosciences
Alain Chedotal, Institut de la Vision, Paris
FP7 Targeting the Leishmania kinome for the development of novel anti-parasitic strategies (LeishDrug)
Visceral leishmaniasis is caused by the protozoan parasites Leishmania donovani and Leishmania infantum and is a potentially fatal disease in endemic areas around the world. During the infectious cycle, Leishmania alternate between the insect […]
PTR 496 – Investigating the reciprocal relationship between macrophage inflammasome activity and intracellular Leishmania infection
Our proposal aims to decipher novel subversion strategies used by Leishmania (i) to withstand, circumvent or inhibit anti-microbial activities of host macrophages and (ii) to interfere with the induction of Leishmania-specific immune responses. We […]
Dual microscopy assay to discriminate Listeria cellular entry & vacuolar escape
We developed a novel image-based microscopy assay which allows to discriminate Listeria monocytogenes cellular entry from vacuolar escape, enabling high-content screening to identify factors specifically involved in these two steps. We generated a L. […]
2017Assessing Vacuolar Escape of Listeria Monocytogenes, Methods Mol. Biol. 2017;1535:173-195.
2016Screening out irrelevant cell-based models of disease, Nat Rev Drug Discov 2016 11;15(11):751-769.
2016From Drug Screening to Target Deconvolution: a Target-Based Drug Discovery Pipeline Using Leishmania Casein Kinase 1 Isoform 2 To Identify Compounds with Antileishmanial Activity, Antimicrob. Agents Chemother. 2016 May;60(5):2822-33.
2015A Dual Microscopy-Based Assay To Assess Listeria monocytogenes Cellular Entry and Vacuolar Escape, Appl. Environ. Microbiol. 2015 Oct;82(1):211-7.
2014Shigella subverts the host recycling compartment to rupture its vacuole, Cell Host Microbe 2014 Oct;16(4):517-30.
2013Pharmacological assessment defines Leishmania donovani casein kinase 1 as a drug target and reveals important functions in parasite viability and intracellular infection, Antimicrob. Agents Chemother. 2014;58(3):1501-15.
2013The 4 Notch receptors play distinct and antagonistic roles in the proliferation and hepatocytic differentiation of liver progenitors, FASEB J. 2014 Feb;28(2):603-14.
2013High content analysis of primary macrophages hosting proliferating Leishmania amastigotes: application to anti-leishmanial drug discovery, PLoS Negl Trop Dis 2013;7(4):e2154.
2009HIV-1 Nef inhibits ruffles, induces filopodia, and modulates migration of infected lymphocytes, J. Virol. 2010 Mar;84(5):2282-93.
2009Intracellular bacteria encode inhibitory SNARE-like proteins, PLoS ONE 2009 Oct;4(10):e7375.
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