• 2024
  Lena Le Quellec , Andrey Aristov , Salomé Gutiérrez Ramos, Gabriel Amselem, Julia Bos, Zeynep Baharoglu, Didier Mazel, Charles N. Baroud, Measuring single-cell susceptibility to antibiotics within monoclonal bacterial populations, https://doi.org/10.1371/journal.pone.0303630.
• 2024
  Fruchard Louna, Babosan Anamaria, Carvalho Andre, Lang Manon, Li Blaise, Duchateau Magalie, Giai-Gianetto Quentin, Matondo Mariette, Bonhomme Frédéric, Hatin Isabelle, Arbes Hugo, Fabret Céline, Sanchez Guillaume, Marchand Virginie, Motorin Yuri, Namy Olivier, de Crécy-Lagard Valérie, Mazel Didier, Baharoglu Zeynep, Aminoglycoside tolerance in Vibrio cholerae engages translational reprogramming associated to queuosine tRNA modification, Elife.
• 2024
  Egill Richard, Baptiste Darracq, Eloi Littner, Claire Vit, Clémence Whiteway, Julia Bos, Florian Fournes, Geneviève Garriss, Valentin Conte, Delphine Lapaillerie, Vincent Parissi, François Rousset, Ole Skovgaard, David Bikard, Eduardo P. C. Rocha, Didier Mazel, Céline Loot, Cassette recombination dynamics within chromosomal integrons are regulated by toxin-antitoxin systems., Science Advances , 2024, 10 (2), pp.eadj3498. ⟨10.1126/sciadv.adj3498⟩.
• 2024
  Loot C, Millot GA, Richard E, Littner E, Vit C, Lemoine F, Néron B, Cury J, Darracq B, Niault T, Lapaillerie D, Parissi V, Rocha EPC, Mazel D, Integron cassettes integrate into bacterial genomes via widespread non-classical attG sites., Nat Microbiol 2024 Jan; 9(1): 228-240.
• 2023
  Larotonda L, Mornico D, Khanna V, Bernal-Bayard J, Ghigo JM, Val ME, Comerci D, Mazel D, Soler-Bistué A, Chromosomal Position of Ribosomal Protein Genes Affects Long-Term Evolution of Vibrio cholerae., mBio 2023 Apr; 14(2): e0343222.
• 2023
  López-Igual R, Dorado-Morales P, Mazel D, , Increasing the Scalability of Toxin-Intein Orthogonal Combinations., ACS Synth Biol 2023 Jan; (): .
• 2022
  Krin E, Baharoglu Z, Sismeiro O, Varet H, Coppée JY, Mazel D, , Systematic transcriptome analysis allows the identification of new type I and type II Toxin/Antitoxin systems located in the superintegron of Vibrio cholerae., Res Microbiol 2023 ; 174(1-2): 103997.
• 2021
  Carvalho A, Krin E, Korlowski C, Mazel D, Baharoglu Z, , Interplay between Sublethal Aminoglycosides and Quorum Sensing: Consequences on Survival in V. cholerae., Cells 2021 11; 10(11): .
• 2021
  Fournes F, Niault T, Czarnecki J, Tissier-Visconti A, Mazel D, Val ME, The coordinated replication of Vibrio cholerae’s two chromosomes required the acquisition of a unique domain by the RctB initiator., Nucleic Acids Res 2021 Nov; 49(19): 11119-11133.
• 2021
  Lang M, Krin E, Korlowski C, Sismeiro O, Varet H, Coppée JY, Mazel D, Baharoglu Z, , Sleeping ribosomes: Bacterial signaling triggers RaiA mediated persistence to aminoglycosides., iScience 2021 Oct; 24(10): 103128.
• 2021
  Carvalho A, Mazel D, Baharoglu Z, , Deficiency in cytosine DNA methylation leads to high chaperonin expression and tolerance to aminoglycosides in Vibrio cholerae., PLoS Genet 2021 10; 17(10): e1009748.
• 2021
  Vit C, Richard E, Fournes F, Whiteway C, Eyer X, Lapaillerie D, Parissi V, Mazel D, Loot C, Cassette recruitment in the chromosomal Integron of Vibrio cholerae., Nucleic Acids Res 2021 Jun; 49(10): 5654-5670.
• 2021
  Bos J, Cisneros LH, Mazel D, , Real-time tracking of bacterial membrane vesicles reveals enhanced membrane traffic upon antibiotic exposure., Sci Adv 2021 Jan; 7(4): .
• 2020
  Escudero JA, Nivina A, Kemble HE, Loot C, Tenaillon O, Mazel D, Primary and promiscuous functions coexist during evolutionary innovation through whole protein domain acquisitions., Elife 2020 Dec; 9(): .
• 2020
  Aleksandra Nivina, Maj Svea Grieb, Céline Loot, David Bikard, Jean Cury, Laila Shehata, Juliana Bernardes, Didier Mazel, Structure-specific DNA recombination sites: Design, validation, and machine learning–based refinement, Science Advances , 2020, 6 (30), pp.eaay2922. ⟨10.1126/sciadv.aay2922⟩.
• 2020
  Soler-Bistué A, Aguilar-Pierlé S, Garcia-Garcerá M, Val ME, Sismeiro O, Varet H, Sieira R, Krin E, Skovgaard O, Comerci DJ, Rocha EPC, Mazel D, Macromolecular crowding links ribosomal protein gene dosage to growth rate in Vibrio cholerae., BMC Biol 2020 Apr; 18(1): 43.
• 2019
  Negro V, Krin E, Aguilar Pierlé S, Chaze T, Giai Gianetto Q, Kennedy SP, Matondo M, Mazel D, Baharoglu Z, , RadD Contributes to R-Loop Avoidance in Sub-MIC Tobramycin., mBio 2019 07; 10(4): .
• 2019
  Lopez-Igual R., Bernal-Bayard J., Rodriguez-Paton A., Ghigo J.-M., and Mazel D., Engineered toxin-intein antimicrobials can selectively target and kill antibiotic-resistant bacteria in mixed populations, Nat Biotechnol. 2019 Jul;37(7):755-760. doi: 10.1038/s41587-019-0105-3. Epub 2019 Apr 15..
• 2018
  de Lemos Martins F, Fournes F, Mazzuoli MV, Mazel D, Val ME, Vibrio cholerae chromosome 2 copy number is controlled by the methylation-independent binding of its monomeric initiator to the chromosome 1 crtS site., Nucleic Acids Res 2018 Nov; 46(19): 10145-10156.
• 2018
  Krin E, Pierlé SA, Sismeiro O, Jagla B, Dillies MA, Varet H, Irazoki O, Campoy S, Rouy Z, Cruveiller S, Médigue C, Coppée JY, Mazel D, Expansion of the SOS regulon of Vibrio cholerae through extensive transcriptome analysis and experimental validation, BMC Genomics 2018 May;19(1):373.
• 2018
  Escudero JA, Nivina A, Cambray G, López-Igual R, Loot C, Mazel D, Recoding of synonymous genes to expand evolutionary landscapes requires control of secondary structure affecting translation., Biotechnol Bioeng 2018 Jan; 115(1): 184-191.
• 2018
  Fournes F, Val ME, Skovgaard O, Mazel D, Replicate Once Per Cell Cycle: Replication Control of Secondary Chromosomes., Front Microbiol 2018 ; 9(): 1833.
• 2017
  Grieb MS, Nivina A, Cheeseman BL, Hartmann A, Mazel D and Schlierf M, Dynamic stepwise opening of integron attC DNA hairpins by SSB prevents toxicity and ensures functionality, Nucleic Acids Research (2017) 45(18):10555-10563. doi: 10.1093/nar/gkx670 .
• 2017
  Bland MJ, Ducos-Galand M, Val ME, Mazel D, An att site-based recombination reporter system for genome engineering and synthetic DNA assembly., BMC Biotechnol 2017 Jul; 17(1): 62.
• 2017
  Céline Loot, Aleksandra Nivina, Jean Cury, José Antonio Escudero, Magaly Ducos-Galand, David Bikard, Eduardo P C Rocha, Didier Mazel, Differences in Integron Cassette Excision Dynamics Shape a Trade-Off between Evolvability and Genetic Capacitance., mBio, 2017, 8 (2), pp.e02296-16. ⟨10.1128/mBio.02296-16⟩.
• 2017
  Soler-Bistué Alfonso, Timmermans Michaël, Mazel Didier, The Proximity of Ribosomal Protein Genes to oriC Enhances Vibrio cholerae Fitness in the Absence of Multifork Replication, MBio. 2017 Feb 28;8(1). pii: e00097-17. doi: 10.1128/mBio.00097-17..
• 2016
  Nivina A, Escudero JA, Vit C, Mazel D, Loot C, Efficiency of integron cassette insertion in correct orientation is ensured by the interplay of the three unpaired features of attC recombination sites., Nucleic Acids Res 2016 Sep; 44(16): 7792-803.
• 2016
  Val ME, Marbouty M, de Lemos Martins F, Kennedy SP, Kemble H, Bland MJ, Possoz C, Koszul R, Skovgaard O, Mazel D, A checkpoint control orchestrates the replication of the two chromosomes of Vibrio cholerae., Sci Adv 2016 Apr; 2(4): e1501914.
• 2016
  Escudero JA, Loot C, Parissi V, Nivina A, Bouchier C, Mazel D, Unmasking the ancestral activity of integron integrases reveals a smooth evolutionary transition during functional innovation., Nat Commun 2016 Mar; 7(): 10937.
• 2015
  Goudenège D, Travers MA, Lemire A, Petton B, Haffner P, Labreuche Y, Tourbiez D, Mangenot S, Calteau A, Mazel D, Nicolas JL, Jacq A, Le Roux F, A single regulatory gene is sufficient to alter Vibrio aestuarianus pathogenicity in oysters, Environ Microbiol. 2015 Nov;17(11):4189-99.
• 2015
  Iqbal N, Guérout AM, Krin E, Le Roux F, Mazel D, Comprehensive Functional Analysis of the 18 Vibrio cholerae N16961 Toxin-Antitoxin Systems Substantiates Their Role in Stabilizing the Superintegron, J. Bacteriol. 2015 Jul;197(13):2150-9.
• 2014
  Val ME, Soler-Bistué A, Bland MJ, Mazel D, Management of multipartite genomes: the Vibrio cholerae model., Curr Opin Microbiol 2014 Dec; 22(): 120-6.
• 2014
  Baharoglu Z, Mazel D, , SOS, the formidable strategy of bacteria against aggressions., FEMS Microbiol Rev 2014 Nov; 38(6): 1126-45.
• 2014
  Mazel D, Colwell R, Klose K, Oliver J, Crumlish M, McDougald D, Bland MJ, Austin B, VIBRIO 2014 meeting report, Res. Microbiol. 2014 Dec;165(10):857-64.
• 2014
  Baharoglu Z, Mazel D, Influence of very short patch mismatch repair on SOS inducing lesions after aminoglycoside treatment in Escherichia coli, Res. Microbiol. 2014 Jul-Aug;165(6):476-80.
• 2014
  Krin E, Cambray G, Mazel D, The superintegron integrase and the cassette promoters are co-regulated in Vibrio cholerae, PLoS ONE 2014;9(3):e91194.
• 2014
  Val ME, Kennedy SP, Soler-Bistué AJ, Barbe V, Bouchier C, Ducos-Galand M, Skovgaard O, Mazel D, Fuse or die: how to survive the loss of Dam in Vibrio cholerae., Mol Microbiol 2014 Feb; 91(4): 665-78.
• 2014
  Baharoglu Z, Babosan A, Mazel D, , Identification of genes involved in low aminoglycoside-induced SOS response in Vibrio cholerae: a role for transcription stalling and Mfd helicase., Nucleic Acids Res 2014 Feb; 42(4): 2366-79.
• 2014
  Loot C, Parissi V, Escudero JA, Amarir-Bouhram J, Bikard D, Mazel D, The integron integrase efficiently prevents the melting effect of Escherichia coli single-stranded DNA-binding protein on folded attC sites., J Bacteriol 2014 Feb; 196(4): 762-71.
• 2013
  Goudenège D, Labreuche Y, Krin E, Ansquer D, Mangenot S, Calteau A, Médigue C, Mazel D, Polz MF, Le Roux F, Comparative genomics of pathogenic lineages of Vibrio nigripulchritudo identifies virulence-associated traits, ISME J 2013 Oct;7(10):1985-96.
• 2013
  Guérout AM, Iqbal N, Mine N, Ducos-Galand M, Van Melderen L, Mazel D, Characterization of the phd-doc and ccd toxin-antitoxin cassettes from Vibrio superintegrons, J. Bacteriol. 2013 May;195(10):2270-83.
• 2013
  Bikard D, Mazel D, Shuffling of DNA cassettes in a synthetic integron, Methods Mol. Biol. 2013;1073:169-74.
• 2013
  Baharoglu Z, Krin E, Mazel D, , RpoS plays a central role in the SOS induction by sub-lethal aminoglycoside concentrations in Vibrio cholerae., PLoS Genet 2013 ; 9(4): e1003421.
• 2012
  Mazel D, Mobashery S, Antibiotics as physiological stress inducers and bacterial response to the challenge, Curr. Opin. Microbiol. 2012 Oct;15(5):553-4.
• 2012
  Hocquet D, Llanes C, Thouverez M, Kulasekara HD, Bertrand X, Plésiat P, Mazel D, Miller SI, Evidence for induction of integron-based antibiotic resistance by the SOS response in a clinical setting, PLoS Pathog. 2012;8(6):e1002778.
• 2012
  Baharoglu Z, Krin E, Mazel D, , Connecting environment and genome plasticity in the characterization of transformation-induced SOS regulation and carbon catabolite control of the Vibrio cholerae integron integrase., J Bacteriol 2012 Apr; 194(7): 1659-67.
• 2012
  Lesic B, Zouine M, Ducos-Galand M, Huon C, Rosso ML, Prévost MC, Mazel D, Carniel E, A natural system of chromosome transfer in Yersinia pseudotuberculosis., PLoS Genet 2012 ; 8(3): e1002529.
• 2011
  Guérin E, Jové T, Tabesse A, Mazel D, Ploy MC, High-level gene cassette transcription prevents integrase expression in class 1 integrons, J. Bacteriol. 2011 Oct;193(20):5675-82.
• 2011
  Baharoglu Z, Mazel D, , Vibrio cholerae triggers SOS and mutagenesis in response to a wide range of antibiotics: a route towards multiresistance., Antimicrob Agents Chemother 2011 May; 55(5): 2438-41.
• 2011
  Cambray G, Sanchez-Alberola N, Campoy S, Guerin E, Da Re S, González-Zorn B, Ploy MC, Barbé J, Mazel D, Erill I, Prevalence of SOS-mediated control of integron integrase expression as an adaptive trait of chromosomal and mobile integrons, Mob DNA 2011;2(1):6.
• 2010
  Ferrières L, Hémery G, Nham T, Guérout AM, Mazel D, Beloin C, Ghigo JM, Silent mischief: bacteriophage Mu insertions contaminate products of Escherichia coli random mutagenesis performed using suicidal transposon delivery plasmids mobilized by broad-host-range RP4 conjugative machinery, J. Bacteriol. 2010 Dec;192(24):6418-27.
• 2010
  Le Roux F, Labreuche Y, Davis BM, Iqbal N, Mangenot S, Goarant C, Mazel D, Waldor MK, Virulence of an emerging pathogenic lineage of Vibrio nigripulchritudo is dependent on two plasmids, Environ. Microbiol. 2011 Feb;13(2):296-306.
• 2010
  Thompson FL, Thompson CC, Vicente AC, Klose KE, , Vibrio2009: the third international conference on the biology of Vibrios, Mol. Microbiol. 2010 Sep;77(5):1065-71.
• 2010
  Labreuche Y, Le Roux F, Henry J, Zatylny C, Huvet A, Lambert C, Soudant P, Mazel D, Nicolas JL, Vibrio aestuarianus zinc metalloprotease causes lethality in the Pacific oyster Crassostrea gigas and impairs the host cellular immune defenses, Fish Shellfish Immunol. 2010 Nov;29(5):753-8.
• 2010
  Bikard D, Julié-Galau S, Cambray G, Mazel D, The synthetic integron: an in vivo genetic shuffling device, Nucleic Acids Res. 2010 Aug;38(15):e153.
• 2010
  Duperthuy M, Binesse J, Le Roux F, Romestand B, Caro A, Got P, Givaudan A, Mazel D, Bachère E, Destoumieux-Garzón D, The major outer membrane protein OmpU of Vibrio splendidus contributes to host antimicrobial peptide resistance and is required for virulence in the oyster Crassostrea gigas, Environ. Microbiol. 2010 Apr;12(4):951-63.
• 2010
  Jové T, Da Re S, Denis F, Mazel D, Ploy MC, Inverse correlation between promoter strength and excision activity in class 1 integrons, PLoS Genet. 2010 Jan;6(1):e1000793.
• 2010
  Cambray G, Guerout AM, Mazel D, Integrons, Annu. Rev. Genet. 2010;44:141-66.
• 2010
  Guérin E, Cambray G, Da Re S, Mazel D, Ploy MC, [The SOS response controls antibiotic resistance by regulating the integrase of integrons], Med Sci (Paris) 2010 Jan;26(1):28-30.
• 2009
  Frumerie C, Ducos-Galand M, Gopaul DN, Mazel D, The relaxed requirements of the integron cleavage site allow predictable changes in integron target specificity, Nucleic Acids Res. 2010 Jan;38(2):559-69.
• 2009
  Jacquier H, Zaoui C, Sanson-le Pors MJ, Mazel D, Berçot B, Translation regulation of integrons gene cassette expression by the attC sites, Mol. Microbiol. 2009 Jun;72(6):1475-86.
• 2009
  Guerin E, Cambray G, Sanchez-Alberola N, Campoy S, Erill I, Da Re S, Gonzalez-Zorn B, Barbé J, Ploy MC, Mazel D, The SOS response controls integron recombination, Science 2009 May;324(5930):1034.
• 2009
  Le Roux F, Zouine M, Chakroun N, Binesse J, Saulnier D, Bouchier C, Zidane N, Ma L, Rusniok C, Lajus A, Buchrieser C, Médigue C, Polz MF, Mazel D, Genome sequence of Vibrio splendidus: an abundant planctonic marine species with a large genotypic diversity, Environ. Microbiol. 2009 Aug;11(8):1959-70.
• 2008
  Cambray G, Mazel D, Synonymous genes explore different evolutionary landscapes, PLoS Genet. 2008 Nov;4(11):e1000256.
• 2008
  Binesse J, Delsert C, Saulnier D, Champomier-Vergès MC, Zagorec M, Munier-Lehmann H, Mazel D, Le Roux F, Metalloprotease vsm is the major determinant of toxicity for extracellular products of Vibrio splendidus, Appl. Environ. Microbiol. 2008 Dec;74(23):7108-17.
• 2008
  Babic A, Guérout AM, Mazel D, Construction of an improved RP4 (RK2)-based conjugative system, Res. Microbiol. 2008 Sep-Oct;159(7-8):545-9.
• 2008
  Reynaud Y, Saulnier D, Mazel D, Goarant C, Le Roux F, Correlation between detection of a plasmid and high-level virulence of Vibrio nigripulchritudo, a pathogen of the shrimp Litopenaeus stylirostris, Appl. Environ. Microbiol. 2008 May;74(10):3038-47.
• 2008
  Wilde C, Mazel D, Hochhut B, Middendorf B, Le Roux F, Carniel E, Dobrindt U, Hacker J, Delineation of the recombination sites necessary for integration of pathogenicity islands II and III into the Escherichia coli 536 chromosome, Mol. Microbiol. 2008 Apr;68(1):139-51.
• 2007
  Demarre G, Frumerie C, Gopaul DN, Mazel D, Identification of key structural determinants of the IntI1 integron integrase that influence attC x attI1 recombination efficiency, Nucleic Acids Res. 2007;35(19):6475-89.
• 2007
  Cattoir V, Poirel L, Mazel D, Soussy CJ, Nordmann P, Vibrio splendidus as the source of plasmid-mediated QnrS-like quinolone resistance determinants, Antimicrob. Agents Chemother. 2007 Jul;51(7):2650-1.
• 2007
  Szekeres S, Dauti M, Wilde C, Mazel D, Rowe-Magnus DA, Chromosomal toxin-antitoxin loci can diminish large-scale genome reductions in the absence of selection, Mol. Microbiol. 2007 Mar;63(6):1588-605.
• 2007
  Wilbaux M, Mine N, Guérout AM, Mazel D, Van Melderen L, Functional interactions between coexisting toxin-antitoxin systems of the ccd family in Escherichia coli O157:H7, J. Bacteriol. 2007 Apr;189(7):2712-9.
• 2006
  Le Roux F, Binesse J, Saulnier D, Mazel D, Construction of a Vibrio splendidus mutant lacking the metalloprotease gene vsm by use of a novel counterselectable suicide vector, Appl. Environ. Microbiol. 2007 Feb;73(3):777-84.
• 2006
  Mazel D, Integrons: agents of bacterial evolution, Nat. Rev. Microbiol. 2006 Aug;4(8):608-20.
• 2006
  MacDonald D, Demarre G, Bouvier M, Mazel D, Gopaul DN, Structural basis for broad DNA-specificity in integron recombination, Nature 2006 Apr;440(7088):1157-62.
• 2005
  Bouvier M, Demarre G, Mazel D, Integron cassette insertion: a recombination process involving a folded single strand substrate, EMBO J. 2005 Dec;24(24):4356-67.
• 2005
  Val ME, Bouvier M, Campos J, Sherratt D, Cornet F, Mazel D, Barre FX, The single-stranded genome of phage CTX is the form used for integration into the genome of Vibrio cholerae., Mol Cell 2005 Aug; 19(4): 559-66.
• 2005
  Skurnik D, Le Menac'h A, Zurakowski D, Mazel D, Courvalin P, Denamur E, Andremont A, Ruimy R, Integron-associated antibiotic resistance and phylogenetic grouping of Escherichia coli isolates from healthy subjects free of recent antibiotic exposure, Antimicrob. Agents Chemother. 2005 Jul;49(7):3062-5.
• 2005
  Demarre G, Guérout AM, Matsumoto-Mashimo C, Rowe-Magnus DA, Marlière P, Mazel D, A new family of mobilizable suicide plasmids based on broad host range R388 plasmid (IncW) and RP4 plasmid (IncPalpha) conjugative machineries and their cognate Escherichia coli host strains, Res. Microbiol. 2005 Mar;156(2):245-55.
• 2005
  Biskri L, Bouvier M, Guérout AM, Boisnard S, Mazel D, Comparative study of class 1 integron and Vibrio cholerae superintegron integrase activities, J. Bacteriol. 2005 Mar;187(5):1740-50.
• 2004
  Matsumoto-Mashimo C, Guerout AM, Mazel D, A new family of conditional replicating plasmids and their cognate Escherichia coli host strains, Res. Microbiol. 2004 Jul-Aug;155(6):455-61.
• 2003
  Biskri L, Mazel D, Erythromycin esterase gene ere(A) is located in a functional gene cassette in an unusual class 2 integron, Antimicrob. Agents Chemother. 2003 Oct;47(10):3326-31.
• 2003
  Rowe-Magnus DA, Guerout AM, Biskri L, Bouige P, Mazel D, Comparative analysis of superintegrons: engineering extensive genetic diversity in the Vibrionaceae, Genome Res. 2003 Mar;13(3):428-42.
• 2002
  Rowe-Magnus DA, Mazel D, The role of integrons in antibiotic resistance gene capture, Int. J. Med. Microbiol. 2002 Jul;292(2):115-25.
• 2002
  Rowe-Magnus DA, Guerout AM, Mazel D, Bacterial resistance evolution by recruitment of super-integron gene cassettes, Mol. Microbiol. 2002 Mar;43(6):1657-69.