• 2024
  Gedeon A, Yab E, Dinut A, Sadowski E, Capton E, Dreneau A, Petit J, Gioia B, Piveteau C, Djaout K, Lecat E, Wehenkel AM, Gubellini F, Mechaly A, Alzari PM, Deprez B, Baulard A, Aubry A, Willand N, Petrella S, Molecular mechanism of a triazole-containing inhibitor of Mycobacterium tuberculosis DNA gyrase., iScience 2024 Oct; 27(10): 110967.
• 2024
  Legru A, Batista FA, Puszko AK, Bouillon A, Maurel M, Martinez M, Ejjoummany A, Ortega Varga L, Adler P, Méchaly A, Hadjadj M, Sosnowski P, Hopfgartner G, Alzari PM, Blondel A, Haouz A, Barale JC, Hernandez JF, Insights from structure-activity relationships and the binding mode of peptidic α-ketoamide inhibitors of the malaria drug target subtilisin-like SUB1., Eur J Med Chem 2024 Apr; 269(): 116308.
• 2024
  Martinez M, Bouillon A, Brûlé S, Raynal B, Haouz A, Alzari PM, Barale J-C, Prodomain-driven enzyme dimerization: a pH-dependent autoinhibition mechanism that controls Plasmodium Sub1 activity before merozoite egress., mBio 2024 Mar; 15(3): e0019824.
• 2023
  Martinez M, Petit J, Leyva A, Sogues A, Megrian D, Rodriguez A, Gaday Q, Ben Assaya M, Portela MM, Haouz A, Ducret A, Grangeasse C, Alzari PM, Durán R, Wehenkel AM, Eukaryotic-like gephyrin and cognate membrane receptor coordinate corynebacterial cell division and polar elongation., Nat Microbiol 2023 Sep; (): .
• 2023
  Yang L, Wagner T, Mechaly A, Boyko A, Bruch EM, Megrian D, Gubellini F, Alzari PM, Bellinzoni M, High resolution cryo-EM and crystallographic snapshots of the actinobacterial two-in-one 2-oxoglutarate dehydrogenase., Nat Commun 2023 Aug; 14(1): 4851.
• 2022
  Gaday Q, Megrian D, Carloni G, Martinez M, Sokolova B, Ben Assaya M, Legrand P, Brûlé S, Haouz A, Wehenkel AM, Alzari PM, , FtsEX-independent control of RipA-mediated cell separation in Corynebacteriales., Proc Natl Acad Sci U S A 2022 Dec; 119(50): e2214599119.
• 2021
  Bruch EM, Vilela P, Yang L, Boyko A, Lexa-Sapart N, Raynal B, Alzari PM, Bellinzoni M, , Actinobacteria challenge the paradigm: A unique protein architecture for a well-known, central metabolic complex., Proc Natl Acad Sci U S A 2021 Nov; 118(48): .
• 2021
  Nika Pende, Adrià Sogues, Daniela Megrian, Anna Sartori-Rupp, Patrick England, Hayk Palabikyan, Simon K. -M. R Rittmann, Martín Graña, Anne Marie Wehenkel, Pedro M. Alzari, Simonetta Gribaldo, SepF is the FtsZ anchor in archaea, with features of an ancestral cell division system, Nature Communications, 2021, 12 (1), pp.3214. ⟨10.1038/s41467-021-23099-8⟩.
• 2020
  Sogues A, Martinez M, Gaday Q, Ben Assaya M, Graña M, Voegele A, VanNieuwenhze M, England P, Haouz A, Chenal A, Trépout S, Duran R, Wehenkel AM, Alzari PM, , Essential dynamic interdependence of FtsZ and SepF for Z-ring and septum formation in Corynebacterium glutamicum., Nat Commun 2020 Apr; 11(1): 1641.
• 2020
  Morgada MN, Llases ME, Giannini E, Castro MA, Alzari PM, Murgida DH, Lisa MN, Vila AJ, Unexpected electron spin density on the axial methionine ligand in Cu suggests its involvement in electron pathways, Chem. Commun. (Camb.) 2020 Jan;56(8):1223-1226.
• 2019
  Weber P, Pissis C, Navaza R, Mechaly AE, Saul F, Alzari PM, Haouz A, High-Throughput Crystallization Pipeline at the Crystallography Core Facility of the Institut Pasteur, Molecules 2019 Dec;24(24).
• 2019
  Wagner T, Boyko A, Alzari PM, Bunik VI, Bellinzoni M, , Conformational transitions in the active site of mycobacterial 2-oxoglutarate dehydrogenase upon binding phosphonate analogues of 2-oxoglutarate: From a Michaelis-like complex to ThDP adducts., J Struct Biol 2019 11; 208(2): 182-190.
• 2019
  Llases ME, Lisa MN, Morgada MN, Giannini E, Alzari PM, Vila AJ, Arabidopsis thaliana Hcc1 is a Sco-like metallochaperone for Cu assembly in Cytochrome c Oxidase, FEBS J. 2020 Feb;287(4):749-762.
• 2019
  Bellinzoni M, Wehenkel AM, Durán R, Alzari PM, , Novel mechanistic insights into physiological signaling pathways mediated by mycobacterial Ser/Thr protein kinases., Microbes Infect ; 21(5-6): 222-229.
• 2019
  Wagner T, André-Leroux G, Hindie V, Barilone N, Lisa MN, Hoos S, Raynal B, Vulliez-Le Normand B, O'Hare HM, Bellinzoni M, Alzari PM, , Structural insights into the functional versatility of an FHA domain protein in mycobacterial signaling., Sci Signal 2019 05; 12(580): .
• 2019
  Bellinzoni M, Wehenkel AM, Durán R, Alzari PM, , Novel mechanistic insights into physiological signaling pathways mediated by mycobacterial Ser/Thr protein kinases., Genes Immun 2019 05; 20(5): 383-393.
• 2019
  Lisa MN, Cvirkaite-Krupovic V, Richet E, André-Leroux G, Alzari PM, Haouz A, Danot O, Double autoinhibition mechanism of signal transduction ATPases with numerous domains (STAND) with a tetratricopeptide repeat sensor, Nucleic Acids Res. 2019 Apr;47(7):3795-3810.
• 2019
  Benini S, Haouz A, Proux F, Alzari P, Wilson K, The crystal structure of Rv2991 from Mycobacterium tuberculosis: An F binding protein with unknown function, J. Struct. Biol. 2019 May;206(2):216-224.
• 2019
  Gil M, Lima A, Rivera B, Rossello J, Urdániz E, Cascioferro A, Carrión F, Wehenkel A, Bellinzoni M, Batthyány C, Pritsch O, Denicola A, Alvarez MN, Carvalho PC, Lisa MN, Brosch R, Piuri M, Alzari PM, Durán R, , New substrates and interactors of the mycobacterial Serine/Threonine protein kinase PknG identified by a tailored interactomic approach., J Proteomics 2019 Feb; 192(): 321-333.
• 2019
  Petrella S, Capton E, Raynal B, Giffard C, Thureau A, Bonneté F, Alzari PM, Aubry A, Mayer C, Overall Structures of Mycobacterium tuberculosis DNA Gyrase Reveal the Role of a Corynebacteriales GyrB-Specific Insert in ATPase Activity, Structure 2019 04;27(4):579-589.e5.
• 2018
  Palacios AR, Mojica MF, Giannini E, Taracila MA, Bethel CR, Alzari PM, Otero LH, Klinke S, Llarrull LI, Bonomo RA, Vila AJ, The Reaction Mechanism of Metallo-β-Lactamases Is Tuned by the Conformation of an Active-Site Mobile Loop, Antimicrob. Agents Chemother. 2019 Jan;63(1).
• 2018
  Chen Z, Marcé P, Resende R, Alzari PM, Frasch AC, van den Elsen JMH, Crennell SJ, Watts AG, The synthesis and kinetic evaluation of aryl α-aminophosphonates as novel inhibitors of T. cruzi trans-sialidase, Eur J Med Chem 2018 Oct;158:25-33.
• 2018
  Mechaly AE, Haouz A, Sassoon N, Buschiazzo A, Betton JM, Alzari PM, Conformational plasticity of the response regulator CpxR, a key player in Gammaproteobacteria virulence and drug-resistance, J. Struct. Biol. 2018 Nov;204(2):165-171.
• 2017
  Mechaly AE, Soto Diaz S, Sassoon N, Buschiazzo A, Betton JM, Alzari PM, Structural Coupling between Autokinase and Phosphotransferase Reactions in a Bacterial Histidine Kinase, Structure 2017 Jun;25(6):939-944.e3.
• 2017
  Rieck B, Degiacomi G, Zimmermann M, Cascioferro A, Boldrin F, Lazar-Adler NR, Bottrill AR, le Chevalier F, Frigui W, Bellinzoni M, Lisa MN, Alzari PM, Nguyen L, Brosch R, Sauer U, Manganelli R, O'Hare HM, , PknG senses amino acid availability to control metabolism and virulence of Mycobacterium tuberculosis., PLoS Pathog 2017 May; 13(5): e1006399.
• 2017
  Lisa MN, Wagner T, Alexandre M, Barilone N, Raynal B, Alzari PM, Bellinzoni M, , The crystal structure of PknI from Mycobacterium tuberculosis shows an inactive, pseudokinase-like conformation., FEBS J 2017 02; 284(4): 602-614.
• 2016
  Martinez M, Duclert-Savatier N, Betton JM, Alzari PM, Nilges M, Malliavin TE, Modification in hydrophobic packing of HAMP domain induces a destabilization of the auto-phosphorylation site in the histidine kinase CpxA, Biopolymers 2016 Oct;105(10):670-82.
• 2016
  Schulze JO, Saladino G, Busschots K, Neimanis S, Süß E, Odadzic D, Zeuzem S, Hindie V, Herbrand AK, Lisa MN, Alzari PM, Gervasio FL, Biondi RM, Bidirectional Allosteric Communication between the ATP-Binding Site and the Regulatory PIF Pocket in PDK1 Protein Kinase, Cell Chem Biol 2016 Sep;.
• 2016
  Le NH, Molle V, Eynard N, Miras M, Stella A, Bardou F, Galandrin S, Guillet V, André-Leroux G, Bellinzoni M, Alzari P, Mourey L, Burlet-Schiltz O, Daffé M, Marrakchi H, , Ser/Thr Phosphorylation Regulates the Fatty Acyl-AMP Ligase Activity of FadD32, an Essential Enzyme in Mycolic Acid Biosynthesis., J Biol Chem 2016 Oct; 291(43): 22793-22805.
• 2016
  Rodrigo-Unzueta A, Martínez MA, Comino N, Alzari PM, Chenal A, Guerin ME, , Molecular Basis of Membrane Association by the Phosphatidylinositol Mannosyltransferase PimA Enzyme from Mycobacteria., J Biol Chem 2016 Jul; 291(27): 13955-13963.
• 2015
  East A, Mechaly AE, Huysmans GHM, Bernarde C, Tello-Manigne D, Nadeau N, Pugsley AP, Buschiazzo A, Alzari PM, Bond PJ, Francetic O, Structural Basis of Pullulanase Membrane Binding and Secretion Revealed by X-Ray Crystallography, Molecular Dynamics and Biochemical Analysis, Structure 2016 Jan;24(1):92-104.
• 2015
  Mori G, Chiarelli LR, Esposito M, Makarov V, Bellinzoni M, Hartkoorn RC, Degiacomi G, Boldrin F, Ekins S, de Jesus Lopes Ribeiro AL, Marino LB, Centárová I, Svetlíková Z, Blaško J, Kazakova E, Lepioshkin A, Barilone N, Zanoni G, Porta A, Fondi M, Fani R, Baulard AR, Mikušová K, Alzari PM, Manganelli R, de Carvalho LP, Riccardi G, Cole ST, Pasca MR, , Thiophenecarboxamide Derivatives Activated by EthA Kill Mycobacterium tuberculosis by Inhibiting the CTP Synthetase PyrG., Chem Biol 2015 Jul; 22(7): 917-27.
• 2015
  Wagner T, Alexandre M, Duran R, Barilone N, Wehenkel A, Alzari PM, Bellinzoni M, , The crystal structure of the catalytic domain of the ser/thr kinase PknA from M. tuberculosis shows an Src-like autoinhibited conformation., Proteins 2015 May; 83(5): 982-8.
• 2014
  Giganti D, Albesa-Jové D, Urresti S, Rodrigo-Unzueta A, Martínez MA, Comino N, Barilone N, Bellinzoni M, Chenal A, Guerin ME, Alzari PM, , Secondary structure reshuffling modulates glycosyltransferase function at the membrane., Nat Chem Biol 2015 Jan; 11(1): 16-8.
• 2014
  Bellinzoni M, Haouz A, Miras I, Magnet S, André-Leroux G, Mukherjee R, Shepard W, Cole ST, Alzari PM, , Structural studies suggest a peptidoglycan hydrolase function for the Mycobacterium tuberculosis Tat-secreted protein Rv2525c., J Struct Biol 2014 Nov; 188(2): 156-64.
• 2014
  Giganti D, Bouillon A, Tawk L, Robert F, Martinez M, Crublet E, Weber P, Girard-Blanc C, Petres S, Haouz A, Hernandez JF, Mercereau-Puijalon O, Alzari PM, Barale JC, A novel Plasmodium-specific prodomain fold regulates the malaria drug target SUB1 subtilase, Nat Commun 2014 Sep;5:4833.
• 2014
  Correa A, Pacheco S, Mechaly AE, Obal G, Béhar G, Mouratou B, Oppezzo P, Alzari PM, Pecorari F, Potent and specific inhibition of glycosidases by small artificial binding proteins (affitins), PLoS ONE 2014;9(5):e97438.
• 2014
  Correa A, Ortega C, Obal G, Alzari P, Vincentelli R, Oppezzo P, Generation of a vector suite for protein solubility screening, Front Microbiol 2014;5:67.
• 2014
  Mechaly AE, Sassoon N, Betton JM, Alzari PM, Segmental helical motions and dynamical asymmetry modulate histidine kinase autophosphorylation, PLoS Biol. 2014 Jan;12(1):e1001776.
• 2013
  Albesa-Jové D, Giganti D, Jackson M, Alzari PM, Guerin ME, Structure-function relationships of membrane-associated GT-B glycosyltransferases, Glycobiology 2014 Feb;24(2):108-24.
• 2013
  Béhar G, Bellinzoni M, Maillasson M, Paillard-Laurance L, Alzari PM, He X, Mouratou B, Pecorari F, , Tolerance of the archaeal Sac7d scaffold protein to alternative library designs: characterization of anti-immunoglobulin G Affitins., Protein Eng Des Sel 2013 Apr; 26(4): 267-75.
• 2013
  Albanesi D, Reh G, Guerin ME, Schaeffer F, Debarbouille M, Buschiazzo A, Schujman GE, de Mendoza D, Alzari PM, Structural basis for feed-forward transcriptional regulation of membrane lipid homeostasis in Staphylococcus aureus, PLoS Pathog. 2013 Jan;9(1):e1003108.
• 2012
  Busschots K, Lopez-Garcia LA, Lammi C, Stroba A, Zeuzem S, Piiper A, Alzari PM, Neimanis S, Arencibia JM, Engel M, Schulze JO, Biondi RM, Substrate-selective inhibition of protein kinase PDK1 by small compounds that bind to the PIF-pocket allosteric docking site, Chem. Biol. 2012 Sep;19(9):1152-63.
• 2012
  Urresti S, Albesa-Jové D, Schaeffer F, Pham HT, Kaur D, Gest P, van der Woerd MJ, Carreras-González A, López-Fernández S, Alzari PM, Brennan PJ, Jackson M, Guerin ME, Mechanistic insights into the retaining glucosyl-3-phosphoglycerate synthase from mycobacteria, J. Biol. Chem. 2012 Jul;287(29):24649-61.
• 2012
  Mechaly AE, Haouz A, Miras I, Barilone N, Weber P, Shepard W, Alzari PM, Bellinzoni M, , Conformational changes upon ligand binding in the essential class II fumarase Rv1098c from Mycobacterium tuberculosis., FEBS Lett 2012 Jun; 586(11): 1606-11.
• 2011
  Lopez-Garcia LA, Schulze JO, Fröhner W, Zhang H, Süss E, Weber N, Navratil J, Amon S, Hindie V, Zeuzem S, Jørgensen TJ, Alzari PM, Neimanis S, Engel M, Biondi RM, Allosteric regulation of protein kinase PKCζ by the N-terminal C1 domain and small compounds to the PIF-pocket, Chem. Biol. 2011 Nov;18(11):1463-73.
• 2011
  Oppezzo P, Obal G, Baraibar MA, Pritsch O, Alzari PM, Buschiazzo A, Crystal structure of an enzymatically inactive trans-sialidase-like lectin from Trypanosoma cruzi: the carbohydrate binding mechanism involves residual sialidase activity, Biochim. Biophys. Acta 2011 Sep;1814(9):1154-61.
• 2010
  Guerin ME, Korduláková J, Alzari PM, Brennan PJ, Jackson M, Molecular basis of phosphatidyl-myo-inositol mannoside biosynthesis and regulation in mycobacteria, J. Biol. Chem. 2010 Oct;285(44):33577-83.
• 2010
  Martinez MA, Zaballa ME, Schaeffer F, Bellinzoni M, Albanesi D, Schujman GE, Vila AJ, Alzari PM, de Mendoza D, , A novel role of malonyl-ACP in lipid homeostasis., Biochemistry 2010 Apr; 49(14): 3161-7.
• 2009
  Bellinzoni M, Buroni S, Schaeffer F, Riccardi G, De Rossi E, Alzari PM, , Structural plasticity and distinct drug-binding modes of LfrR, a mycobacterial efflux pump regulator., J Bacteriol 2009 Dec; 191(24): 7531-7.
• 2009
  Albanesi D, Martín M, Trajtenberg F, Mansilla MC, Haouz A, Alzari PM, de Mendoza D, Buschiazzo A, Structural plasticity and catalysis regulation of a thermosensor histidine kinase, Proc. Natl. Acad. Sci. U.S.A. 2009 Sep;106(38):16185-90.
• 2009
  Hindie V, Stroba A, Zhang H, Lopez-Garcia LA, Idrissova L, Zeuzem S, Hirschberg D, Schaeffer F, Jørgensen TJ, Engel M, Alzari PM, Biondi RM, Structure and allosteric effects of low-molecular-weight activators on the protein kinase PDK1, Nat. Chem. Biol. 2009 Oct;5(10):758-64.
• 2009
  Boucontet L, Grana M, Alzari PM, Pereira P, Mechanisms determining cell membrane expression of different gammadelta TCR chain pairings, Eur. J. Immunol. 2009 Jul;39(7):1937-46.
• 2009
  Guerin ME, Schaeffer F, Chaffotte A, Gest P, Giganti D, Korduláková J, van der Woerd M, Jackson M, Alzari PM, Substrate-induced conformational changes in the essential peripheral membrane-associated mannosyltransferase PimA from mycobacteria: implications for catalysis, J. Biol. Chem. 2009 Aug;284(32):21613-25.
• 2009
  Bellinzoni M, Alzari PM, , Bacterial metabolism under FHA control., Structure 2009 Apr; 17(4): 487-8.
• 2009
  Martín M, Albanesi D, Alzari PM, de Mendoza D, Functional in vitro assembly of the integral membrane bacterial thermosensor DesK, Protein Expr. Purif. 2009 Jul;66(1):39-45.
• 2009
  Sala C, Haouz A, Saul FA, Miras I, Rosenkrands I, Alzari PM, Cole ST, Genome-wide regulon and crystal structure of BlaI (Rv1846c) from Mycobacterium tuberculosis, Mol. Microbiol. 2009 Mar;71(5):1102-16.
• 2008
  Neres J, Brewer ML, Ratier L, Botti H, Buschiazzo A, Edwards PN, Mortenson PN, Charlton MH, Alzari PM, Frasch AC, Bryce RA, Douglas KT, Discovery of novel inhibitors of Trypanosoma cruzi trans-sialidase from in silico screening, Bioorg. Med. Chem. Lett. 2009 Feb;19(3):589-96.
• 2008
  Buschiazzo A, Alzari PM, Structural insights into sialic acid enzymology, Curr Opin Chem Biol 2008 Oct;12(5):565-72.
• 2008
  Krehenbrink M, Chami M, Guilvout I, Alzari PM, Pécorari F, Pugsley AP, Artificial binding proteins (Affitins) as probes for conformational changes in secretin PulD, J. Mol. Biol. 2008 Nov;383(5):1058-68.
• 2008
  Balganesh TS, Alzari PM, Cole ST, Rising standards for tuberculosis drug development, Trends Pharmacol. Sci. 2008 Nov;29(11):576-81.
• 2008
  Damager I, Buchini S, Amaya MF, Buschiazzo A, Alzari P, Frasch AC, Watts A, Withers SG, Kinetic and mechanistic analysis of Trypanosoma cruzi trans-sialidase reveals a classical ping-pong mechanism with acid/base catalysis, Biochemistry 2008 Mar;47(11):3507-12.
• 2008
  Ahmed F, André-Leroux G, Haouz A, Boutonnier A, Delepierre M, Qadri F, Nato F, Fournier JM, Alzari PM, Crystal structure of a monoclonal antibody directed against an antigenic determinant common to Ogawa and Inaba serotypes of Vibrio cholerae O1, Proteins 2008 Jan;70(1):284-8.
• 2007
  Mouratou B, Schaeffer F, Guilvout I, Tello-Manigne D, Pugsley AP, Alzari PM, Pecorari F, Remodeling a DNA-binding protein as a specific in vivo inhibitor of bacterial secretin PulD, Proc. Natl. Acad. Sci. U.S.A. 2007 Nov;104(46):17983-8.
• 2007
  Cole ST, Alzari PM, Towards new tuberculosis drugs, Biochem. Soc. Trans. 2007 Nov;35(Pt 5):1321-4.
• 2007
  Fernandez P, Haouz A, Pereira CA, Aguilar C, Alzari PM, The crystal structure of Trypanosoma cruzi arginine kinase, Proteins 2007 Oct;69(1):209-12.
• 2007
  Wehenkel A, Bellinzoni M, Graña M, Duran R, Villarino A, Fernandez P, Andre-Leroux G, England P, Takiff H, Cerveñansky C, Cole ST, Alzari PM, , Mycobacterial Ser/Thr protein kinases and phosphatases: physiological roles and therapeutic potential., Biochim Biophys Acta 2008 Jan; 1784(1): 193-202.
• 2007
  Graña M, Haouz A, Buschiazzo A, Miras I, Wehenkel A, Bondet V, Shepard W, Schaeffer F, Cole ST, Alzari PM, The crystal structure of M. leprae ML2640c defines a large family of putative S-adenosylmethionine-dependent methyltransferases in mycobacteria, Protein Sci. 2007 Sep;16(9):1896-904.
• 2007
  Stadthagen G, Sambou T, Guerin M, Barilone N, Boudou F, Korduláková J, Charles P, Alzari PM, Lemassu A, Daffé M, Puzo G, Gicquel B, Rivière M, Jackson M, Genetic basis for the biosynthesis of methylglucose lipopolysaccharides in Mycobacterium tuberculosis, J. Biol. Chem. 2007 Sep;282(37):27270-6.
• 2007
  Topalis D, Kumamoto H, Amaya Velasco MF, Dugué L, Haouz A, Alexandre JA, Gallois-Montbrun S, Alzari PM, Pochet S, Agrofoglio LA, Deville-Bonne D, Nucleotide binding to human UMP-CMP kinase using fluorescent derivatives — a screening based on affinity for the UMP-CMP binding site, FEBS J. 2007 Jul;274(14):3704-14.
• 2007
  Guerin ME, Kordulakova J, Schaeffer F, Svetlikova Z, Buschiazzo A, Giganti D, Gicquel B, Mikusova K, Jackson M, Alzari PM, Molecular recognition and interfacial catalysis by the essential phosphatidylinositol mannosyltransferase PimA from mycobacteria, J. Biol. Chem. 2007 Jul;282(28):20705-14.
• 2007
  Henrik Ingvarsson, María J. Maté, Martin Högbom, Denis Portnoï, Nadia Benaroudj, Pedro Maria Alzari, Miguel Ortiz-Lombardía, Torsten Unge, Insights into the inter-ring plasticity of caseinolytic proteases from the X-ray structure of Mycobacterium tuberculosis ClpP1., Acta crystallographica Section D : Structural biology [1993-..], 2007, 63 (Pt 2), pp.249-59. ⟨10.1107/S0907444906050530⟩.
• 2006
  Shepard W, Haouz A, Graña M, Buschiazzo A, Betton JM, Cole ST, Alzari PM, The crystal structure of Rv0813c from Mycobacterium tuberculosis reveals a new family of fatty acid-binding protein-like proteins in bacteria, J. Bacteriol. 2007 Mar;189(5):1899-904.
• 2006
  Neres J, Bonnet P, Edwards PN, Kotian PL, Buschiazzo A, Alzari PM, Bryce RA, Douglas KT, Benzoic acid and pyridine derivatives as inhibitors of Trypanosoma cruzi trans-sialidase, Bioorg. Med. Chem. 2007 Mar;15(5):2106-19.
• 2006
  Engel M, Hindie V, Lopez-Garcia LA, Stroba A, Schaeffer F, Adrian I, Imig J, Idrissova L, Nastainczyk W, Zeuzem S, Alzari PM, Hartmann RW, Piiper A, Biondi RM, Allosteric activation of the protein kinase PDK1 with low molecular weight compounds, EMBO J. 2006 Nov;25(23):5469-80.
• 2006
  Costabel MD, Ermácora MR, Santomé JA, Alzari PM, Guérin DM, Structure of armadillo ACBP: a new member of the acyl-CoA-binding protein family, Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 2006 Oct;62(Pt 10):958-61.
• 2006
  Alzari PM, Berglund H, Berrow NS, Blagova E, Busso D, Cambillau C, Campanacci V, Christodoulou E, Eiler S, Fogg MJ, Folkers G, Geerlof A, Hart D, Haouz A, Herman MD, Macieira S, Nordlund P, Perrakis A, Quevillon-Cheruel S, Tarandeau F, van Tilbeurgh H, Unger T, Luna-Vargas MP, Velarde M, Willmanns M, Owens RJ, Implementation of semi-automated cloning and prokaryotic expression screening: the impact of SPINE, Acta Crystallogr. D Biol. Crystallogr. 2006 Oct;62(Pt 10):1103-13.
• 2006
  Fogg MJ, Alzari P, Bahar M, Bertini I, Betton JM, Burmeister WP, Cambillau C, Canard B, Corrondo MA, Carrondo M, Coll M, Daenke S, Dym O, Egloff MP, Enguita FJ, Geerlof A, Haouz A, Jones TA, Ma Q, Manicka SN, Migliardi M, Nordlund P, Owens RJ, Peleg Y, Schneider G, Schnell R, Stuart DI, Tarbouriech N, Unge T, Wilkinson AJ, Wilmanns M, Wilson KS, Zimhony O, Grimes JM, Application of the use of high-throughput technologies to the determination of protein structures of bacterial and viral pathogens, Acta Crystallogr. D Biol. Crystallogr. 2006 Oct;62(Pt 10):1196-207.
• 2006
  Albeck S, Alzari P, Andreini C, Banci L, Berry IM, Bertini I, Cambillau C, Canard B, Carter L, Cohen SX, Diprose JM, Dym O, Esnouf RM, Felder C, Ferron F, Guillemot F, Hamer R, Ben Jelloul M, Laskowski RA, Laurent T, Longhi S, Lopez R, Luchinat C, Malet H, Mochel T, Morris RJ, Moulinier L, Oinn T, Pajon A, Peleg Y, Perrakis A, Poch O, Prilusky J, Rachedi A, Ripp R, Rosato A, Silman I, Stuart DI, Sussman JL, Thierry JC, Thompson JD, Thornton JM, Unger T, Vaughan B, Vranken W, Watson JD, Whamond G, Henrick K, SPINE bioinformatics and data-management aspects of high-throughput structural biology, Acta Crystallogr. D Biol. Crystallogr. 2006 Oct;62(Pt 10):1184-95.
• 2006
  Fernandez P, Saint-Joanis B, Barilone N, Jackson M, Gicquel B, Cole ST, Alzari PM, The Ser/Thr protein kinase PknB is essential for sustaining mycobacterial growth, J. Bacteriol. 2006 Nov;188(22):7778-84.
• 2006
  Schujman GE, Guerin M, Buschiazzo A, Schaeffer F, Llarrull LI, Reh G, Vila AJ, Alzari PM, de Mendoza D, Structural basis of lipid biosynthesis regulation in Gram-positive bacteria, EMBO J. 2006 Sep;25(17):4074-83.
• 2006
  Pehar M, Vargas MR, Robinson KM, Cassina P, England P, Beckman JS, Alzari PM, Barbeito L, Peroxynitrite transforms nerve growth factor into an apoptotic factor for motor neurons, Free Radic. Biol. Med. 2006 Dec;41(11):1632-44.
• 2006
  Neres J, Buschiazzo A, Alzari PM, Walsh L, Douglas KT, Continuous fluorimetric assay for high-throughput screening of inhibitors of trans-sialidase from Trypanosoma cruzi, Anal. Biochem. 2006 Oct;357(2):302-4.
• 2006
  Bellinzoni M, Haouz A, Graña M, Munier-Lehmann H, Shepard W, Alzari PM, , The crystal structure of Mycobacterium tuberculosis adenylate kinase in complex with two molecules of ADP and Mg2+ supports an associative mechanism for phosphoryl transfer., Protein Sci 2006 Jun; 15(6): 1489-93.
• 2006
  Buschiazzo A, Goytia M, Schaeffer F, Degrave W, Shepard W, Grégoire C, Chamond N, Cosson A, Berneman A, Coatnoan N, Alzari PM, Minoprio P, Crystal structure, catalytic mechanism, and mitogenic properties of Trypanosoma cruzi proline racemase, Proc. Natl. Acad. Sci. U.S.A. 2006 Feb;103(6):1705-10.
• 2005
  Watts AG, Oppezzo P, Withers SG, Alzari PM, Buschiazzo A, Structural and kinetic analysis of two covalent sialosyl-enzyme intermediates on Trypanosoma rangeli sialidase, J. Biol. Chem. 2006 Feb;281(7):4149-55.
• 2005
  Girardin SE, Jéhanno M, Mengin-Lecreulx D, Sansonetti PJ, Alzari PM, Philpott DJ, Identification of the critical residues involved in peptidoglycan detection by Nod1, J. Biol. Chem. 2005 Nov;280(46):38648-56.
• 2005
  Villarino A, Duran R, Wehenkel A, Fernandez P, England P, Brodin P, Cole ST, Zimny-Arndt U, Jungblut PR, Cerveñansky C, Alzari PM, Proteomic identification of M. tuberculosis protein kinase substrates: PknB recruits GarA, a FHA domain-containing protein, through activation loop-mediated interactions, J. Mol. Biol. 2005 Jul;350(5):953-63.
• 2005
  Guimarães BG, Souchon H, Honoré N, Saint-Joanis B, Brosch R, Shepard W, Cole ST, Alzari PM, Structure and mechanism of the alkyl hydroperoxidase AhpC, a key element of the Mycobacterium tuberculosis defense system against oxidative stress, J. Biol. Chem. 2005 Jul;280(27):25735-42.
• 2005
  Guerin ME, Buschiazzo A, Korduláková J, Jackson M, Alzari PM, Crystallization and preliminary crystallographic analysis of PimA, an essential mannosyltransferase from Mycobacterium smegmatis, Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 2005 May;61(Pt 5):518-20.
• 2005
  Paris G, Ratier L, Amaya MF, Nguyen T, Alzari PM, Frasch AC, A sialidase mutant displaying trans-sialidase activity, J. Mol. Biol. 2005 Jan;345(4):923-34.
• 2005
  Cole ST, Alzari PM, Microbiology. TB–a new target, a new drug, Science 2005 Jan;307(5707):214-5.
• 2004
  Alzari PM, First structural glimpse at a bacterial Ser/Thr protein phosphatase, Structure 2004 Nov;12(11):1923-4.
• 2004
  Freire T, Fernández C, Chalar C, Maizels RM, Alzari P, Osinaga E, Robello C, Characterization of a UDP-N-acetyl-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase with an unusual lectin domain from the platyhelminth parasite Echinococcus granulosus, Biochem. J. 2004 Sep;382(Pt 2):501-10.
• 2004
  Buschiazzo A, Ugalde JE, Guerin ME, Shepard W, Ugalde RA, Alzari PM, Crystal structure of glycogen synthase: homologous enzymes catalyze glycogen synthesis and degradation, EMBO J. 2004 Aug;23(16):3196-205.
• 2004
  Amaya MF, Watts AG, Damager I, Wehenkel A, Nguyen T, Buschiazzo A, Paris G, Frasch AC, Withers SG, Alzari PM, Structural insights into the catalytic mechanism of Trypanosoma cruzi trans-sialidase, Structure 2004 May;12(5):775-84.
• 2003
  Ribard C, Rochet M, Labedan B, Daignan-Fornier B, Alzari P, Scazzocchio C, Oestreicher N, Sub-families of alpha/beta barrel enzymes: a new adenine deaminase family, J. Mol. Biol. 2003 Dec;334(5):1117-31.
• 2003
  Boitel B, Ortiz-Lombardía M, Durán R, Pompeo F, Cole ST, Cerveñansky C, Alzari PM, PknB kinase activity is regulated by phosphorylation in two Thr residues and dephosphorylation by PstP, the cognate phospho-Ser/Thr phosphatase, in Mycobacterium tuberculosis, Mol. Microbiol. 2003 Sep;49(6):1493-508.
• 2003
  Watts AG, Damager I, Amaya ML, Buschiazzo A, Alzari P, Frasch AC, Withers SG, Trypanosoma cruzi trans-sialidase operates through a covalent sialyl-enzyme intermediate: tyrosine is the catalytic nucleophile, J. Am. Chem. Soc. 2003 Jun;125(25):7532-3.
• 2003
  Guerin ME, Buschiazzo A, Ugalde JE, Ugalde RA, Alzari PM, Preliminary crystallographic studies of glycogen synthase from Agrobacterium tumefaciens, Acta Crystallogr. D Biol. Crystallogr. 2003 Mar;59(Pt 3):526-8.
• 2003
  Babino A, Tello D, Rojas A, Bay S, Osinaga E, Alzari PM, The crystal structure of a plant lectin in complex with the Tn antigen, FEBS Lett. 2003 Feb;536(1-3):106-10.
• 2003
  Ortiz-Lombardía M, Pompeo F, Boitel B, Alzari PM, Crystal structure of the catalytic domain of the PknB serine/threonine kinase from Mycobacterium tuberculosis, J. Biol. Chem. 2003 Apr;278(15):13094-100.
• 2003
  Amaya MF, Buschiazzo A, Nguyen T, Alzari PM, The high resolution structures of free and inhibitor-bound Trypanosoma rangeli sialidase and its comparison with T. cruzi trans-sialidase, J. Mol. Biol. 2003 Jan;325(4):773-84.
• 2002
  Buschiazzo A, Amaya MF, Cremona ML, Frasch AC, Alzari PM, The crystal structure and mode of action of trans-sialidase, a key enzyme in Trypanosoma cruzi pathogenesis, Mol. Cell 2002 Oct;10(4):757-68.
• 2002
  Mo F, Mathiesen RH, Alzari PM, Lescar J, Rasmussen B, Physical estimation of triplet phases from two new proteins, Acta Crystallogr. D Biol. Crystallogr. 2002 Oct;58(Pt 10 Pt 2):1780-6.
• 2002
  Schmidt A, Gonzalez A, Morris RJ, Costabel M, Alzari PM, Lamzin VS, Advantages of high-resolution phasing: MAD to atomic resolution, Acta Crystallogr. D Biol. Crystallogr. 2002 Sep;58(Pt 9):1433-41.
• 2002
  Guimarães BG, Souchon H, Lytle BL, David Wu JH, Alzari PM, The crystal structure and catalytic mechanism of cellobiohydrolase CelS, the major enzymatic component of the Clostridium thermocellum Cellulosome, J. Mol. Biol. 2002 Jul;320(3):587-96.
• 2002
  Maté MJ, Ortiz-Lombardía M, Boitel B, Haouz A, Tello D, Susin SA, Penninger J, Kroemer G, Alzari PM, The crystal structure of the mouse apoptosis-inducing factor AIF, Nat. Struct. Biol. 2002 Jun;9(6):442-6.
• 2002
  Montagna G, Cremona ML, Paris G, Amaya MF, Buschiazzo A, Alzari PM, Frasch AC, The trans-sialidase from the african trypanosome Trypanosoma brucei, Eur. J. Biochem. 2002 Jun;269(12):2941-50.
• 2002
  Smith SP, Béguin P, Alzari PM, Gehring K, 1H, 13C, 15N NMR sequence-specific resonance assignment of a Clostridium thermocellum type II cohesin module, J. Biomol. NMR 2002 May;23(1):73-4.
• 2002
  Carpena X, Guarné A, Ferrer JC, Alzari PM, Fita I, Loewen PC, Crystallization and preliminary X-ray analysis of the hydroperoxidase I C-terminal domain from Escherichia coli, Acta Crystallogr. D Biol. Crystallogr. 2002 May;58(Pt 5):853-5.
• 2002
  Mowat CG, Leys D, McLean KJ, Rivers SL, Richmond A, Munro AW, Ortiz Lombardia M, Alzari PM, Reid GA, Chapman SK, Walkinshaw MD, Crystallization and preliminary crystallographic analysis of a novel cytochrome P450 from Mycobacterium tuberculosis, Acta Crystallogr. D Biol. Crystallogr. 2002 Apr;58(Pt 4):704-5.
• 2002
  Chernyak A, Kondo S, Wade TK, Meeks MD, Alzari PM, Fournier JM, Taylor RK, Kovác P, Wade WF, Induction of protective immunity by synthetic Vibrio cholerae hexasaccharide derived from V. cholerae O1 Ogawa lipopolysaccharide bound to a protein carrier, J. Infect. Dis. 2002 Apr;185(7):950-62.
• 2002
  Guérin DM, Lascombe MB, Costabel M, Souchon H, Lamzin V, Béguin P, Alzari PM, Atomic (0.94 A) resolution structure of an inverting glycosidase in complex with substrate, J. Mol. Biol. 2002 Mar;316(5):1061-9.
• 2002
  Miras I, Schaeffer F, Béguin P, Alzari PM, Mapping by site-directed mutagenesis of the region responsible for cohesin-dockerin interaction on the surface of the seventh cohesin domain of Clostridium thermocellum CipA, Biochemistry 2002 Feb;41(7):2115-9.
• 2002
  Schaeffer F, Matuschek M, Guglielmi G, Miras I, Alzari PM, Béguin P, Duplicated dockerin subdomains of Clostridium thermocellum endoglucanase CelD bind to a cohesin domain of the scaffolding protein CipA with distinct thermodynamic parameters and a negative cooperativity, Biochemistry 2002 Feb;41(7):2106-14.
• 2001
  Eckenberg R, Rose T, Moreau JL, Weil R, Gesbert F, Dubois S, Tello D, Bossus M, Gras H, Tartar A, Bertoglio J, Chouaïb S, Jacques Y, Alzari PM, Thèze J, Characterization of an IL-2 mimetic with therapeutic potential, Cell. Mol. Biol. (Noisy-le-grand) 2001 Jun;47(4):703-7.
• 2001
  Paris G, Cremona ML, Amaya MF, Buschiazzo A, Giambiagi S, Frasch AC, Alzari PM, Probing molecular function of trypanosomal sialidases: single point mutations can change substrate specificity and increase hydrolytic activity, Glycobiology 2001 Apr;11(4):305-11.
• 2001
  Pitcovsky TA, Mucci J, Alvarez P, Leguizamón MS, Burrone O, Alzari PM, Campetella O, Epitope mapping of trans-sialidase from Trypanosoma cruzi reveals the presence of several cross-reactive determinants, Infect. Immun. 2001 Mar;69(3):1869-75.
• 2000
  Pritsch O, Magnac C, Dumas G, Bouvet JP, Alzari P, Dighiero G, Can isotype switch modulate antigen-binding affinity and influence clonal selection?, Eur. J. Immunol. 2000 Dec;30(12):3387-95.
• 2000
  Villeneuve S, Souchon H, Riottot MM, Mazie JC, Lei P, Glaudemans CP, Kovác P, Fournier JM, Alzari PM, Crystal structure of an anti-carbohydrate antibody directed against Vibrio cholerae O1 in complex with antigen: molecular basis for serotype specificity, Proc. Natl. Acad. Sci. U.S.A. 2000 Jul;97(15):8433-8.
• 2000
  Lascombe MB, Grégoire C, Poncet P, Tavares GA, Rosinski-Chupin I, Rabillon J, Goubran-Botros H, Mazié JC, David B, Alzari PM, Crystal structure of the allergen Equ c 1. A dimeric lipocalin with restricted IgE-reactive epitopes, J. Biol. Chem. 2000 Jul;275(28):21572-7.
• 2000
  Oppezzo P, Osinaga E, Tello D, Bay S, Cantacuzene D, Irigoín F, Ferreira A, Roseto A, Cayota A, Alzari P, Pritsch O, Production and functional characterization of two mouse/human chimeric antibodies with specificity for the tumor-associated Tn-antigen, Hybridoma 2000 Jun;19(3):229-39.
• 2000
  Osinaga E, Bay S, Tello D, Babino A, Pritsch O, Assemat K, Cantacuzene D, Nakada H, Alzari P, Analysis of the fine specificity of Tn-binding proteins using synthetic glycopeptide epitopes and a biosensor based on surface plasmon resonance spectroscopy, FEBS Lett. 2000 Mar;469(1):24-8.
• 2000
  Medeiros A, Bianchi S, Calvete JJ, Balter H, Bay S, Robles A, Cantacuzène D, Nimtz M, Alzari PM, Osinaga E, Biochemical and functional characterization of the Tn-specific lectin from Salvia sclarea seeds, Eur. J. Biochem. 2000 Mar;267(5):1434-40.
• 2000
  Eckenberg R, Rose T, Moreau JL, Weil R, Gesbert F, Dubois S, Tello D, Bossus M, Gras H, Tartar A, Bertoglio J, Chouaïb S, Goldberg M, Jacques Y, Alzari PM, Thèze J, The first alpha helix of interleukin (IL)-2 folds as a homotetramer, acts as an agonist of the IL-2 receptor beta chain, and induces lymphokine-activated killer cells, J. Exp. Med. 2000 Feb;191(3):529-40.
• 2000
  Buschiazzo A, Tavares GA, Campetella O, Spinelli S, Cremona ML, París G, Amaya MF, Frasch AC, Alzari PM, Structural basis of sialyltransferase activity in trypanosomal sialidases, EMBO J. 2000 Jan;19(1):16-24.
• 1999
  Barale JC, Blisnick T, Fujioka H, Alzari PM, Aikawa M, Braun-Breton C, Langsley G, Plasmodium falciparum subtilisin-like protease 2, a merozoite candidate for the merozoite surface protein 1-42 maturase, Proc. Natl. Acad. Sci. U.S.A. 1999 May;96(11):6445-50.
• 1999
  Marina A, Alzari PM, Bravo J, Uriarte M, Barcelona B, Fita I, Rubio V, Carbamate kinase: New structural machinery for making carbamoyl phosphate, the common precursor of pyrimidines and arginine, Protein Sci. 1999 Apr;8(4):934-40.
• 1999
  Grégoire C, Tavares GA, Lorenzo HK, Dandeu JP, David B, Alzari PM, Crystallization and preliminary crystallographic analysis of the major horse allergen Equ c 1, Acta Crystallogr. D Biol. Crystallogr. 1999 Apr;55(Pt 4):880-2.
• 1999
  Saint-Joanis B, Souchon H, Wilming M, Johnsson K, Alzari PM, Cole ST, Use of site-directed mutagenesis to probe the structure, function and isoniazid activation of the catalase/peroxidase, KatG, from Mycobacterium tuberculosis, Biochem. J. 1999 Mar;338 ( Pt 3):753-60.
• 1999
  Maté MJ, Zamocky M, Nykyri LM, Herzog C, Alzari PM, Betzel C, Koller F, Fita I, Structure of catalase-A from Saccharomyces cerevisiae, J. Mol. Biol. 1999 Feb;286(1):135-49.
• 1999
  Susin SA, Lorenzo HK, Zamzami N, Marzo I, Brenner C, Larochette N, Prévost MC, Alzari PM, Kroemer G, Mitochondrial release of caspase-2 and -9 during the apoptotic process, J. Exp. Med. 1999 Jan;189(2):381-94.
• 1998
  Terenzi H, Alzari PM, Zakin MM, Structural features involved in the formation of a complex between the monomeric or the dimeric form of the rev-erb beta DNA-binding domain and its DNA reactive sites, Biochemistry 1998 Aug;37(33):11488-95.
• 1998
  Béguin P, Alzari PM, The cellulosome of Clostridium thermocellum, Biochem. Soc. Trans. 1998 May;26(2):178-85.
• 1998
  Demangel C, Rouyre S, Alzari PM, Nato F, Longacre S, Lafaye P, Mazie JC, Phage-displayed mimotopes elicit monoclonal antibodies specific for a malaria vaccine candidate, Biol. Chem. 1998 Jan;379(1):65-70.
• 1997
  Guillouard I, Alzari PM, Saliou B, Cole ST, The carboxy-terminal C2-like domain of the alpha-toxin from Clostridium perfringens mediates calcium-dependent membrane recognition, Mol. Microbiol. 1997 Dec;26(5):867-76.
• 1997
  Tavares GA, Béguin P, Alzari PM, The crystal structure of a type I cohesin domain at 1.7 A resolution, J. Mol. Biol. 1997 Oct;273(3):701-13.
• 1997
  Babino A, Pritsch O, Oppezzo P, Du Pasquier R, Roseto A, Osinaga E, Alzari PM, Molecular cloning of a monoclonal anti-tumor antibody specific for the Tn antigen and expression of an active single-chain Fv fragment, Hybridoma 1997 Aug;16(4):317-24.
• 1997
  Osinaga E, Tello D, Batthyany C, Bianchet M, Tavares G, Durán R, Cerveñansky C, Camoin L, Roseto A, Alzari PM, Amino acid sequence and three-dimensional structure of the Tn-specific isolectin B4 from Vicia villosa, FEBS Lett. 1997 Jul;412(1):190-6.
• 1997
  Lorenzo HK, Farber D, Germain V, Acuto O, Alzari PM, The MBP fusion protein restores the activity of the first phosphatase domain of CD45, FEBS Lett. 1997 Jul;411(2-3):231-5.
• 1997
  Eckenberg R, Xu D, Moreau JL, Bossus M, Mazie JC, Tartar A, Liu XY, Alzari PM, Bertoglio J, Theze J, Analysis of human IL-2/IL-2 receptor beta chain interactions: monoclonal antibody H2-8 and new IL-2 mutants define the critical role of alpha helix-A of IL-2, Cytokine 1997 Jul;9(7):488-98.
• 1997
  Berthet S, Nykyri LM, Bravo J, Mate MJ, Berthet-Colominas C, Alzari PM, Koller F, Fita I, Crystallization and preliminary structural analysis of catalase A from Saccharomyces cerevisiae, Protein Sci. 1997 Feb;6(2):481-3.
• 1997
  Diaw L, Magnac C, Pritsch O, Buckle M, Alzari PM, Dighiero G, Structural and affinity studies of IgM polyreactive natural autoantibodies, J. Immunol. 1997 Jan;158(2):968-76.
• 1996
  Gregoire C, Rosinski-Chupin I, Rabillon J, Alzari PM, David B, Dandeu JP, cDNA cloning and sequencing reveal the major horse allergen Equ c1 to be a glycoprotein member of the lipocalin superfamily, J. Biol. Chem. 1996 Dec;271(51):32951-9.
• 1996
  Thèze J, Alzari PM, Bertoglio J, Interleukin 2 and its receptors: recent advances and new immunological functions, Immunol. Today 1996 Oct;17(10):481-6.
• 1996
  Béguin P, Raynaud O, Chaveroche MK, Dridi A, Alzari PM, Subcloning of a DNA fragment encoding a single cohesin domain of the Clostridium thermocellum cellulosome-integrating protein CipA: purification, crystallization, and preliminary diffraction analysis of the encoded polypeptide, Protein Sci. 1996 Jun;5(6):1192-4.
• 1996
  Souchon H, Béguin P, Alzari PM, Crystallization of a family 8 cellulase from Clostridium thermocellum, Proteins 1996 May;25(1):134-6.
• 1996
  Domínguez R, Souchon H, Lascombe M, Alzari PM, The crystal structure of a family 5 endoglucanase mutant in complexed and uncomplexed forms reveals an induced fit activation mechanism, J. Mol. Biol. 1996 Apr;257(5):1042-51.
• 1996
  Alzari PM, Souchon H, Dominguez R, The crystal structure of endoglucanase CelA, a family 8 glycosyl hydrolase from Clostridium thermocellum, Structure 1996 Mar;4(3):265-75.
• 1996
  Strynadka NC, Jensen SE, Alzari PM, James MN, A potent new mode of beta-lactamase inhibition revealed by the 1.7 A X-ray crystallographic structure of the TEM-1-BLIP complex, Nat. Struct. Biol. 1996 Mar;3(3):290-7.
• 1996
  Saul FA, Alzari PM, Crystallographic studies of antigen-antibody interactions, Methods Mol. Biol. 1996;66:11-23.
• 1995
  Assemat K, Alzari PM, Clément-Métral J, Conservative substitutions in the hydrophobic core of Rhodobacter sphaeroides thioredoxin produce distinct functional effects, Protein Sci. 1995 Dec;4(12):2510-6.
• 1995
  Lescar J, Pellegrini M, Souchon H, Tello D, Poljak RJ, Peterson N, Greene M, Alzari PM, Crystal structure of a cross-reaction complex between Fab F9.13.7 and guinea fowl lysozyme, J. Biol. Chem. 1995 Jul;270(30):18067-76.
• 1995
  Dominguez R, Souchon H, Spinelli S, Dauter Z, Wilson KS, Chauvaux S, Béguin P, Alzari PM, A common protein fold and similar active site in two distinct families of beta-glycanases, Nat. Struct. Biol. 1995 Jul;2(7):569-76.
• 1995
  Chitarra V, Souchon H, Spinelli S, Juy M, Béguin P, Alzari PM, Multiple crystal forms of endoglucanase CelD: signal peptide residues modulate lattice formation, J. Mol. Biol. 1995 Apr;248(2):225-32.
• 1995
  Chauvaux S, Souchon H, Alzari PM, Chariot P, Beguin P, Structural and functional analysis of the metal-binding sites of Clostridium thermocellum endoglucanase CelD, J. Biol. Chem. 1995 Apr;270(17):9757-62.
• 1995
  Heym B, Alzari PM, Honoré N, Cole ST, Missense mutations in the catalase-peroxidase gene, katG, are associated with isoniazid resistance in Mycobacterium tuberculosis, Mol. Microbiol. 1995 Jan;15(2):235-45.
• 1994
  Guelpa-Fonlupt V, Bossy D, Alzari P, Fumoux F, Fougereau M, Schiff C, The human pre-B cell receptor: structural constraints for a tentative model of the pseudo-light (psi L) chain, Mol. Immunol. 1994 Oct;31(14):1099-108.
• 1994
  Dominguez R, Souchon H, Alzari PM, Characterization of two crystal forms of Clostridium thermocellum endoglucanase CelC, Proteins 1994 Jun;19(2):158-60.
• 1994
  Lescar J, Souchon H, Alzari PM, Crystal structures of pheasant and guinea fowl egg-white lysozymes, Protein Sci. 1994 May;3(5):788-98.
• 1994
  Hoog SS, Pawlowski JE, Alzari PM, Penning TM, Lewis M, Three-dimensional structure of rat liver 3 alpha-hydroxysteroid/dihydrodiol dehydrogenase: a member of the aldo-keto reductase superfamily, Proc. Natl. Acad. Sci. U.S.A. 1994 Mar;91(7):2517-21.
• 1994
  Souchon H, Spinelli S, Béguin P, Alzari PM, Crystallization and preliminary diffraction analysis of the catalytic domain of xylanase Z from Clostridium thermocellum, J. Mol. Biol. 1994 Jan;235(4):1348-50.
• 1994
  Spinelli S, Alzari PM, Structural implications of somatic mutations during the immune response to 2-phenyloxazolone, Res. Immunol. 1994 Jan;145(1):41-5.
• 1993
  Chitarra V, Alzari PM, Bentley GA, Bhat TN, Eiselé JL, Houdusse A, Lescar J, Souchon H, Poljak RJ, Three-dimensional structure of a heteroclitic antigen-antibody cross-reaction complex, Proc. Natl. Acad. Sci. U.S.A. 1993 Aug;90(16):7711-5.
• 1993
  Eiselé JL, Tello D, Osinaga E, Roseto A, Alzari PM, Crystallization and preliminary crystallographic analysis of a tetrameric isolectin from Vicia villosa, specific for the Tn antigen, J. Mol. Biol. 1993 Mar;230(2):670-2.
• 1993
  Lescar J, Riottot MM, Souchon H, Chitarra V, Bentley GA, Navaza J, Alzari PM, Poljak RJ, Crystallization, preliminary X-ray diffraction study, and crystal packing of a complex between anti-hen lysozyme antibody F9.13.7 and guinea-fowl lysozyme, Proteins 1993 Feb;15(2):209-12.
• 1992
  Lascombe MB, Alzari PM, Poljak RJ, Nisonoff A, Three-dimensional structure of two crystal forms of FabR19.9 from a monoclonal anti-arsonate antibody, Proc. Natl. Acad. Sci. U.S.A. 1992 Oct;89(20):9429-33.
• 1991
  Spinelli S, Liu QZ, Alzari PM, Hirel PH, Poljak RJ, The three-dimensional structure of the aspartyl protease from the HIV-1 isolate BRU, Biochimie 1991 Nov;73(11):1391-6.
• 1991
  Brunel F, Alzari PM, Ferrara P, Zakin MM, Cloning and sequencing of PYBP, a pyrimidine-rich specific single strand DNA-binding protein, Nucleic Acids Res. 1991 Oct;19(19):5237-45.
• 1991
  Devaux C, Defendini ML, Alzari PM, Abergel C, Granier C, Fontecilla-Camps JC, Alzar PM, Crystallization and preliminary X-ray diffraction data of the Fab fragment of a monoclonal antibody against apamin, a bee venom neurotoxin, FEBS Lett. 1991 Jul;286(1-2):64-6.
• 1990
  Jores R, Alzari PM, Meo T, Resolution of hypervariable regions in T-cell receptor beta chains by a modified Wu-Kabat index of amino acid diversity, Proc. Natl. Acad. Sci. U.S.A. 1990 Dec;87(23):9138-42.
• 1990
  Alzari PM, Spinelli S, Mariuzza RA, Boulot G, Poljak RJ, Jarvis JM, Milstein C, Three-dimensional structure determination of an anti-2-phenyloxazolone antibody: the role of somatic mutation and heavy/light chain pairing in the maturation of an immune response, EMBO J. 1990 Dec;9(12):3807-14.
• 1990
  González-Quintial R, Baccalà R, Alzari PM, Nahmias C, Mazza G, Fougereau M, Avrameas S, Poly(Glu60Ala30Tyr10) (GAT)-induced IgG monoclonal antibodies cross-react with various self and non-self antigens through the complementarity determining regions. Comparison with IgM monoclonal polyreactive natural antibodies, Eur. J. Immunol. 1990 Nov;20(11):2383-7.
• 1989
  Bentley GA, Alzari PM, Amit AG, Boulot G, Guillon-Chitarra V, Fischmann T, Lascombe MB, Mariuzza RA, Poljak RJ, Riottot MM, Studies of structure and specificity of some antigen-antibody complexes, Philos. Trans. R. Soc. Lond., B, Biol. Sci. 1989 Jun;323(1217):487-94.
• 1989
  Leroy P, Alzari P, Sassoon D, Wolgemuth D, Fellous M, The protein encoded by a murine male germ cell-specific transcript is a putative ATP-dependent RNA helicase, Cell 1989 May;57(4):549-59.
• 1989
  Lascombe MB, Alzari PM, Boulot G, Saludjian P, Tougard P, Berek C, Haba S, Rosen EM, Nisonoff A, Poljak RJ, Three-dimensional structure of Fab R19.9, a monoclonal murine antibody specific for the p-azobenzenearsonate group, Proc. Natl. Acad. Sci. U.S.A. 1989 Jan;86(2):607-11.
• 1988
  Alzari PM, Lascombe MB, Poljak RJ, Three-dimensional structure of antibodies, Annu. Rev. Immunol. 1988;6:555-80.
• 1987
  Guillon V, Alzari PM, Poljak RJ, Preliminary crystallographic study of a complex between an heteroclitic anti-hen egg-white lysozyme antibody and the heterologous antigen pheasant egg-white lysozyme, J. Mol. Biol. 1987 Sep;197(2):375-6.
• 1986
  Guillon V, Alzari PM, Grognet JM, Preliminary crystallographic study of the Fab fragment of a monoclonal antibody directed against a cobra cardiotoxin, J. Mol. Biol. 1986 Jun;189(4):723-4.
• 1986
  Joliff G, Béguin P, Millet J, Aubert JP, Alzari P, Juy M, Poljak RJ, Crystallization and preliminary X-ray diffraction study of an endoglucanase from Clostridium thermocellum, J. Mol. Biol. 1986 May;189(1):249-50.