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2024Differential stress responsiveness determines intraspecies virulence heterogeneity and host adaptation in Listeria monocytogenes., Nat Microbiol 2024 Dec; 9(12): 3345-3361.
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2024Multitrait analysis to decipher the intertwined genetic architecture of neuroanatomical phenotypes and psychiatric disorders., Biol Psychiatry Cogn Neurosci Neuroimaging 2024 Sep; (): .
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2024Protein interaction explorer (PIE): a comprehensive platform for navigating protein-protein interactions and ligand binding pockets., Bioinformatics 2024 Jul; 40(7): .
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2024Trait selection strategy in multi-trait GWAS: Boosting SNP discoverability., HGG Adv 2024 Jul; 5(3): 100319.
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2024An approach to identify gene-environment interactions and reveal new biological insight in complex traits., Nat Commun 2024 Apr; 15(1): 3385.
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2024A comprehensive dataset of protein-protein interactions and ligand binding pockets for advancing drug discovery, Scientific Data , 2024, 11 (1), pp.402. ⟨10.1038/s41597-024-03233-z⟩.
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2024Multi-trait GWAS for diverse ancestries: mapping the knowledge gap., BMC Genomics 2024 Apr; 25(1): 375.
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2024Multi-trait GWAS for diverse ancestries: mapping the knowledge gap., BMC Genomics 2024 Apr; 25(1): 375.
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2024Contactin 2 homophilic adhesion structure and conformational plasticity., Structure 2024 Jan; 32(1): 60-73.e5.
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2023A second update on mapping the human genetic architecture of COVID-19., Nature 2023 Sep; 621(7977): E7-E26.
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2023Gender-based disparities and biases in science: An observational study of a virtual conference., PLoS One 2023 ; 18(6): e0286811.
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2022Structural insights into the contactin 1 – neurofascin 155 adhesion complex., Nat Commun 2022 Nov; 13(1): 6607.
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2022Fitting Gaussian mixture models on incomplete data, BMC Bioinformatics.
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2022Fitting Gaussian mixture models on incomplete data., BMC Bioinformatics 2022 Jun; 23(1): 208.
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2022Portability of 245 polygenic scores when derived from the UK Biobank and applied to 9 ancestry groups from the same cohort., Am J Hum Genet 2022 Jan; 109(1): 12-23.
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2021InDeep: 3D fully convolutional neural networks to assist in silico drug design on protein-protein interactions., Bioinformatics 2022 Feb; 38(5): 1261-1268.
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2021Mapping the human genetic architecture of COVID-19., Nature 2021 Dec; 600(7889): 472-477.
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2021Powerful gene-based testing by integrating long-range chromatin interactions and knockoff genotypes., Proc Natl Acad Sci U S A 2021 11; 118(47): .
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2021Multi-ancestry genome-wide gene-sleep interactions identify novel loci for blood pressure., Mol Psychiatry 2021 Nov; 26(11): 6293-6304.
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2021Multitrait GWAS to connect disease variants and biological mechanisms., PLoS Genet 2021 Aug; 17(8): e1009713.
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2021Genetic meta-analysis of cancer diagnosis following statin use identifies new associations and implicates human leukocyte antigen (HLA) in women., Pharmacogenomics J 2021 08; 21(4): 446-457.
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2021Intraocular Pressure, Glaucoma, and Dietary Caffeine Consumption: A Gene-Diet Interaction Study from the UK Biobank., Ophthalmology 2021 06; 128(6): 866-876.
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2021Gene-educational attainment interactions in a multi-ancestry genome-wide meta-analysis identify novel blood pressure loci., Mol Psychiatry 2021 06; 26(6): 2111-2125.
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2021Estimating the effective sample size in association studies of quantitative traits., G3 (Bethesda) 2021 Mar; (): .
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2021The iPPI-DB initiative: a community-centered database of protein-protein interaction modulators., Bioinformatics 2021 Apr; 37(1): 89-96.
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2020Ultrarare heterozygous pathogenic variants of genes causing dominant forms of early-onset deafness underlie severe presbycusis., Proc Natl Acad Sci U S A 2020 12; 117(49): 31278-31289.
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2020Deriving stratified effects from joint models investigating gene-environment interactions., BMC Bioinformatics 2020 Jun; 21(1): 251.
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2020Mixed-model admixture mapping identifies smoking-dependent loci of lung function in African Americans., Eur J Hum Genet 2020 05; 28(5): 656-668.
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2020JASS: command line and web interface for the joint analysis of GWAS results., NAR Genom Bioinform 2020 Mar; 2(1): lqaa003.
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2020Fine-mapping of 150 breast cancer risk regions identifies 191 likely target genes, Nat. Genet. 2020 Jan;.
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2020Structural Perspectives on Extracellular Recognition and Conformational Changes of Several Type-I Transmembrane Receptors., Front Mol Biosci 2020 ; 7(): 129.
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2019Making the Most of Clumping and Thresholding for Polygenic Scores., Am J Hum Genet 2019 12; 105(6): 1213-1221.
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2019Multi-ancestry sleep-by-SNP interaction analysis in 126,926 individuals reveals lipid loci stratified by sleep duration., Nat Commun 2019 11; 10(1): 5121.
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2019RAISS: robust and accurate imputation from summary statistics., Bioinformatics 2019 11; 35(22): 4837-4839.
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2019A comprehensive study of metabolite genetics reveals strong pleiotropy and heterogeneity across time and context., Nat Commun 2019 10; 10(1): 4788.
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2019Genetic Correlations Between Diabetes and Glaucoma: An Analysis of Continuous and Dichotomous Phenotypes., Am J Ophthalmol 2019 10; 206(): 245-255.
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2019A comprehensive assessment of demographic, environmental, and host genetic associations with gut microbiome diversity in healthy individuals., Microbiome 2019 Sep; 7(1): 130.
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2019A multi-ancestry genome-wide study incorporating gene-smoking interactions identifies multiple new loci for pulse pressure and mean arterial pressure., Hum Mol Genet 2019 08; 28(15): 2615-2633.
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2019Efficient Implementation of Penalized Regression for Genetic Risk Prediction., Genetics 2019 05; 212(1): 65-74.
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2019Multi-ancestry genome-wide gene-smoking interaction study of 387,272 individuals identifies new loci associated with serum lipids., Nat Genet 2019 04; 51(4): 636-648.
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2019Adjusting for Principal Components of Molecular Phenotypes Induces Replicating False Positives., Genetics 2019 Apr; 211(4): 1179-1189.
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2019Genetic effects on the commensal microbiota in inflammatory bowel disease patients., PLoS Genet 2019 03; 15(3): e1008018.
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2019Joint Analysis of Multiple Interaction Parameters in Genetic Association Studies., Genetics 2019 02; 211(2): 483-494.
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2019Multi-ancestry study of blood lipid levels identifies four loci interacting with physical activity., Nat Commun 2019 01; 10(1): 376.
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2018Exploring the genetic basis of human population differences in DNA methylation and their causal impact on immune gene regulation., Genome Biol 2018 12; 19(1): 222.
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2018VarExp: estimating variance explained by genome-wide GxE summary statistics., Bioinformatics 2018 10; 34(19): 3412-3414.
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2018Structural plasticity of the HHD2 domain of whirlin., FEBS J 2018 Oct; 285(20): 3738-3752.
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2018Efficient analysis of large-scale genome-wide data with two R packages: bigstatsr and bigsnpr., Bioinformatics 2018 08; 34(16): 2781-2787.
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2018Structural insights into SorCS2-Nerve Growth Factor complex formation., Nat Commun 2018 Jul; 9(1): 2979.
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2018Human genetic variants and age are the strongest predictors of humoral immune responses to common pathogens and vaccines., Genome Med 2018 Jul; 10(1): 59.
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2018A test for gene-environment interaction in the presence of measurement error in the environmental variable., Genet Epidemiol 2018 04; 42(3): 250-264.
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2018A Large-Scale Multi-ancestry Genome-wide Study Accounting for Smoking Behavior Identifies Multiple Significant Loci for Blood Pressure., Am J Hum Genet 2018 03; 102(3): 375-400.
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2018lme4qtl: linear mixed models with flexible covariance structure for genetic studies of related individuals., BMC Bioinformatics 2018 02; 19(1): 68.
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2018An ancestry-based approach for detecting interactions., Genet Epidemiol 2018 02; 42(1): 49-63.
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2018Testosterone Pathway Genetic Polymorphisms in Relation to Primary Open-Angle Glaucoma: An Analysis in Two Large Datasets., Invest Ophthalmol Vis Sci 2018 02; 59(2): 629-636.
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2018Genome-wide association study in 79,366 European-ancestry individuals informs the genetic architecture of 25-hydroxyvitamin D levels., Nat Commun 2018 01; 9(1): 260.
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2018Distinctive roles of age, sex, and genetics in shaping transcriptional variation of human immune responses to microbial challenges., Proc Natl Acad Sci U S A 2018 Jan; 115(3): E488-E497.
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2018Novel genetic associations for blood pressure identified via gene-alcohol interaction in up to 570K individuals across multiple ancestries., PLoS One 2018 ; 13(6): e0198166.
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2017Covariate selection for association screening in multiphenotype genetic studies., Nat Genet 2017 Dec; 49(12): 1789-1795.
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2017Genetic correlations between intraocular pressure, blood pressure and primary open-angle glaucoma: a multi-cohort analysis., Eur J Hum Genet 2017 11; 25(11): 1261-1267.
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2017Current Challenges and New Opportunities for Gene-Environment Interaction Studies of Complex Diseases., Am J Epidemiol 2017 Oct; 186(7): 753-761.
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2017Update on the State of the Science for Analytical Methods for Gene-Environment Interactions., Am J Epidemiol 2017 Oct; 186(7): 762-770.
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2017Sex-Based Genetic Association Study Identifies CELSR1 as a Possible Chronic Obstructive Pulmonary Disease Risk Locus among Women., Am J Respir Cell Mol Biol 2017 03; 56(3): 332-341.
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2017Age at natural menopause genetic risk score in relation to age at natural menopause and primary open-angle glaucoma in a US-based sample., Menopause 2017 02; 24(2): 150-156.
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2017A comprehensive survey of genetic variation in 20,691 subjects from four large cohorts., PLoS One 2017 ; 12(3): e0173997.
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2016Pancreatic Cancer Risk Associated with Prediagnostic Plasma Levels of Leptin and Leptin Receptor Genetic Polymorphisms., Cancer Res 2016 12; 76(24): 7160-7167.
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2016A perspective on interaction effects in genetic association studies., Genet Epidemiol 2016 Dec; 40(8): 678-688.
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2016Genomewide meta-analysis identifies loci associated with IGF-I and IGFBP-3 levels with impact on age-related traits., Aging Cell 2016 Oct; 15(5): 811-24.
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2016Power Calculation of Multi-step Combined Principal Components with Applications to Genetic Association Studies, Sci Rep 2016 05;6:26243.
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2016Emergence of Antimicrobial-Resistant Escherichia coli of Animal Origin Spreading in Humans., Mol Biol Evol 2016 Apr; 33(4): 898-914.
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2015Leveraging local ancestry to detect gene-gene interactions in genome-wide data., BMC Genet 2015 Oct; 16(): 124.
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2015Fitness cost of antibiotic susceptibility during bacterial infection., Sci Transl Med 2015 Jul; 7(297): 297ra114.
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2015Integrated pathway and epistasis analysis reveals interactive effect of genetic variants at TERF1 and AFAP1L2 loci on melanoma risk, Int. J. Cancer 2015 Oct;137(8):1901-1909.
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2015Finding the missing gene-environment interactions., Eur J Epidemiol 2015 May; 30(5): 353-5.
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2015A common variant in RAB27A gene is associated with fractional exhaled nitric oxide levels in adults, Clin. Exp. Allergy 2015 Apr;45(4):797-806.
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2015Embryonic stem cell specific “master” replication origins at the heart of the loss of pluripotency, PLoS Comput. Biol. 2015 Feb;11(2):e1003969.
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2015Adjusting for heritable covariates can bias effect estimates in genome-wide association studies., Am J Hum Genet 2015 Feb; 96(2): 329-39.
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2015Variation in predictive ability of common genetic variants by established strata: the example of breast cancer and age., Epidemiology 2015 Jan; 26(1): 51-8.
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2014A spontaneous KRT16 mutation in a dog breed: a model for human focal non-epidermolytic palmoplantar keratoderma (FNEPPK), J. Invest. Dermatol. 2015 Apr;135(4):1187-1190.
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2014Maximizing the power of principal-component analysis of correlated phenotypes in genome-wide association studies., Am J Hum Genet 2014 May; 94(5): 662-76.
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2014Rare missense variants in POT1 predispose to familial cutaneous malignant melanoma, Nat. Genet. 2014 May;46(5):482-6.
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2013Enhanced in vivo fitness of carbapenem-resistant oprD mutants of Pseudomonas aeruginosa revealed through high-throughput sequencing., Proc Natl Acad Sci U S A 2013 Dec; 110(51): 20747-52.
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