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© Research
Publication : Bioinformatics (Oxford, England)

RAISS: robust and accurate imputation from summary statistics

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Bioinformatics (Oxford, England) - 01 Nov 2019

Julienne H, Shi H, Pasaniuc B, Aschard H

Link to Pubmed [PMID] – 31173064

Bioinformatics 2019 Nov;35(22):4837-4839

Multi-trait analyses using public summary statistics from genome-wide association studies (GWASs) are becoming increasingly popular. A constraint of multi-trait methods is that they require complete summary data for all traits. Although methods for the imputation of summary statistics exist, they lack precision for genetic variants with small effect size. This is benign for univariate analyses where only variants with large effect size are selected a posteriori. However, it can lead to strong p-value inflation in multi-trait testing. Here we present a new approach that improve the existing imputation methods and reach a precision suitable for multi-trait analyses.

https://www.ncbi.nlm.nih.gov/pubmed/31173064