• 2024
  Popoff MR, Ladant D, Toxins, Pathogenicity, Anti-Toxins, a Bicentennial Contribution., Toxins (Basel) 2024 Feb; 16(2): .
• 2024
  Abettan A, Nguyen MH, Ladant D, Monticelli L, Chenal A, CyaA translocation across eukaryotic cell membranes., Front Mol Biosci 2024 ; 11(): 1359408.
• 2024
  Karimova G, Ladant D, Defining Membrane Protein Topology Using pho-lac Reporter Fusions., Methods Mol Biol 2024 ; 2715(): 181-195.
• 2024
  Karimova G, Gauliard E, Davi M, Ouellette SP, Ladant D, Protein-Protein Interaction: Bacterial Two Hybrid., Methods Mol Biol 2024 ; 2715(): 207-224.
• 2023
  Sadi M, Carvalho N, Léger C, Vitorge B, Ladant D, Guijarro JI, Chenal A, B2LiVe, a label-free 1D-NMR method to quantify the binding of amphitropic peptides or proteins to membrane vesicles., Cell Rep Methods 2023 Nov; 3(11): 100624.
• 2023
  Magda Teixeira Nunes, Pascal Retailleau, Dorothée Raoux-Barbot, Martine Comisso, Anani Amegan Missinou, Christophe Velours, Stéphane Plancqueel, Daniel Ladant, Undine Mechold, Louis Renault, Functional and structural insights into the multi-step activation and catalytic mechanism of bacterial ExoY nucleotidyl cyclase toxins bound to actin-profilin, PLoS Pathogens, 2023, 19 (9), pp.e1011654. ⟨10.1371/journal.ppat.1011654⟩.
• 2023
  Popoff MR, Faure G, Legout S, Ladant D, Animal Toxins: A Historical Outlook at the Institut Pasteur of Paris., Toxins (Basel) 2023 Jul; 15(7): .
• 2023
  Carneiro GB, Castro JT, Davi M, Miyaji EN, Ladant D, Oliveira MLS, Immune responses and protection against Streptococcus pneumoniae elicited by recombinant Bordetella pertussis adenylate cyclase (CyaA) carrying fragments of pneumococcal surface protein A, PspA., Vaccine 2023 Jun; 41(28): 4170-4182.
• 2023
  Ladant D, Prévost G, Popoff MR, Benoit E, Editorial of the Special Issue “Toxins: Mr Hyde or Dr Jekyll?”., Toxins (Basel) 2023 Feb; 15(2): .
• 2023
  Gedeon A, Karimova G, Ayoub N, Dairou J, Giai Gianetto Q, Vichier-Guerre S, Vidalain PO, Ladant D, Munier-Lehmann H, Interaction network among de novo purine nucleotide biosynthesis enzymes in Escherichia coli., FEBS J 2023 Feb; (): .
• 2022
  Davi M, Sadi M, Pitard I, Chenal A, Ladant D, , A Robust and Sensitive Spectrophotometric Assay for the Enzymatic Activity of Bacterial Adenylate Cyclase Toxins., Toxins (Basel) 2022 Oct; 14(10): .
• 2022
  Léger C, Pitard I, Sadi M, Carvalho N, Brier S, Mechaly A, Raoux-Barbot D, Davi M, Hoos S, Weber P, Vachette P, Durand D, Haouz A, Guijarro JI, Ladant D, Chenal A, , Dynamics and structural changes of calmodulin upon interaction with the antagonist calmidazolium., BMC Biol 2022 08; 20(1): 176.
• 2021
  Ladant D, , Bioengineering of Bordetella pertussis Adenylate Cyclase Toxin for Vaccine Development and Other Biotechnological Purposes., Toxins (Basel) 2021 Jan; 13(2): .
• 2019
  O'Brien DP, Cannella SE, Voegele A, Raoux-Barbot D, Davi M, Douché T, Matondo M, Brier S, Ladant D, Chenal A, , Post-translational acylation controls the folding and functions of the CyaA RTX toxin., FASEB J 2019 09; 33(9): 10065-10076.
• 2019
  Ladant D, Buchrieser C, Popoff MR, Editorial: Pathogens and disease special issue ETOX18, Pathog Dis 2019 03;77(2).
• 2019
  Voegele A, Sadi M, Raoux-Barbot D, Douché T, Matondo M, Ladant D, Chenal A, , The Adenylate Cyclase (CyaA) Toxin from Bordetella pertussis Has No Detectable Phospholipase A (PLA) Activity In Vitro., Toxins (Basel) 2019 02; 11(2): .
• 2018
  Raoux-Barbot D, Belyy A, Worpenberg L, Montluc S, Deville C, Henriot V, Velours C, Ladant D, Renault L, Mechold U, Differential regulation of actin-activated nucleotidyl cyclase virulence factors by filamentous and globular actin, PLoS ONE 2018;13(11):e0206133.
• 2018
  Belyy A, Santecchia I, Renault L, Bourigault B, Ladant D, Mechold U, The extreme C terminus of the effector ExoY is crucial for binding to its eukaryotic activator, F-actin, J. Biol. Chem. 2018 12;293(51):19785-19796.
• 2018
  Chenal A, Ladant D, Bioengineering of Adenylate Cyclase Toxin for Antigen-Delivery and Immunotherapy, Toxins (Basel) 2018 Jul;10(7).
• 2018
  Arumugham VB, Ulivieri C, Onnis A, Finetti F, Tonello F, Ladant D, Baldari CT, Compartmentalized Cyclic AMP Production by the and Adenylate Cyclase Toxins Differentially Affects the Immune Synapse in T Lymphocytes, Front Immunol 2018;9:919.
• 2018
  Olson MG, Goldammer M, Gauliard E, Ladant D, Ouellette SP, A Bacterial Adenylate Cyclase-Based Two-Hybrid System Compatible with Gateway Cloning, Methods Mol. Biol. 2018;1794:75-96.
• 2017
  Belyy A, Mechold U, Renault L, Ladant D, ExoY, an actin-activated nucleotidyl cyclase toxin from P. aeruginosa: A minireview, Toxicon 2018 Jul;149:65-71.
• 2017
  Chaoul N, Tang A, Desrues B, Oberkampf M, Fayolle C, Ladant D, Sainz-Perez A, Leclerc C, Lack of MHC class II molecules favors CD8 T-cell infiltration into tumors associated with an increased control of tumor growth, Oncoimmunology 2018;7(3):e1404213.
• 2017
  Ouellette SP, Karimova G, Davi M, Ladant D, Analysis of Membrane Protein Interactions with a Bacterial Adenylate Cyclase-Based Two-Hybrid (BACTH) Technique, Curr Protoc Mol Biol 2017 Apr;118:20.12.1-20.12.24.
• 2017
  Cannella SE, Ntsogo Enguéné VY, Davi M, Malosse C, Sotomayor Pérez AC, Chamot-Rooke J, Vachette P, Durand D, Ladant D, Chenal A, Stability, structural and functional properties of a monomeric, calcium-loaded adenylate cyclase toxin, CyaA, from Bordetella pertussis, Sci Rep 2017 Feb;7:42065.
• 2017
  Karimova G, Gauliard E, Davi M, Ouellette SP, Ladant D, Protein-Protein Interaction: Bacterial Two-Hybrid, Methods Mol. Biol. 2017;1615:159-176.
• 2017
  Karimova G, Ladant D, Defining Membrane Protein Topology Using pho-lac Reporter Fusions, Methods Mol. Biol. 2017;1615:129-142.
• 2016
  Belyy A*, Raoux-Barbot D*, Saveanu C*, Namane A, Ogryzko V, Worpenberg L, David V, Henriot V, Fellous S, Merrifield C, Assayag E, Ladant D, Renault L, Mechold U, Actin activates Pseudomonas aeruginosa ExoY nucleotidyl cyclase toxin and ExoY-like effector domains from MARTX toxins, Nat Commun 2016 Dec;7:13582.
• 2015
  O'Brien DP, Hernandez B, Durand D, Hourdel V, Sotomayor-Pérez AC, Vachette P, Ghomi M, Chamot-Rooke J, Ladant D, Brier S, Chenal A, Structural models of intrinsically disordered and calcium-bound folded states of a protein adapted for secretion., Sci Rep 2015 Sep; 5(): 14223.
• 2015
  A. Chenal, A.C. Sotomayor-Perez and Daniel Ladant., Structure and function of RTX toxins., The Comprehensive Sourcebook of Bacterial Protein Toxins, Fourth Edition..
• 2015
  Chaoul N, Fayolle C, Desrues B, Oberkampf M, Tang A, Ladant D, Leclerc C, Rapamycin Impairs Antitumor CD8+ T-cell Responses and Vaccine-Induced Tumor Eradication, Cancer Res. 2015 Aug;75(16):3279-91.
• 2015
  Gauliard E, Ouellette SP, Rueden KJ, Ladant D, Characterization of interactions between inclusion membrane proteins from Chlamydia trachomatis, Front Cell Infect Microbiol 2015;5:13.
• 2014
  Sotomayor-Pérez AC, Ladant D, Chenal A, Disorder-to-order transition in the CyaA toxin RTX domain: implications for toxin secretion, Toxins (Basel) 2014 Dec;7(1):1-20.
• 2014
  Karst JC, Ntsogo Enguéné VY, Cannella SE, Subrini O, Hessel A, Debard S, Ladant D, Chenal A, Calcium, acylation, and molecular confinement favor folding of Bordetella pertussis adenylate cyclase CyaA toxin into a monomeric and cytotoxic form, J. Biol. Chem. 2014 Oct;289(44):30702-16.
• 2014
  Dadaglio G, Fayolle C, Zhang X, Ryffel B, Oberkampf M, Felix T, Hervas-Stubbs S, Osicka R, Sebo P, Ladant D, Leclerc C, Antigen targeting to CD11b+ dendritic cells in association with TLR4/TRIF signaling promotes strong CD8+ T cell responses, J. Immunol. 2014 Aug;193(4):1787-98.
• 2014
  Beckert U, Wolter S, Hartwig C, Bähre H, Kaever V, Ladant D, Frank DW, Seifert R, ExoY from Pseudomonas aeruginosa is a nucleotidyl cyclase with preference for cGMP and cUMP formation, Biochem. Biophys. Res. Commun. 2014 Jul;450(1):870-4.
• 2014
  Ouellette SP, Rueden KJ, Gauliard E, Persons L, de Boer PA, Ladant D, Analysis of MreB interactors in Chlamydia reveals a RodZ homolog but fails to detect an interaction with MraY, Front Microbiol 2014;5:279.
• 2013
  Ouellette SP, Gauliard E, Antosová Z, Ladant D, A Gateway(®) -compatible bacterial adenylate cyclase-based two-hybrid system, Environ Microbiol Rep 2014 Jun;6(3):259-67.
• 2013
  Subrini O, Sotomayor-Pérez AC, Hessel A, Spiaczka-Karst J, Selwa E, Sapay N, Veneziano R, Pansieri J, Chopineau J, Ladant D, Chenal A, Characterization of a membrane-active peptide from the Bordetella pertussis CyaA toxin, J. Biol. Chem. 2013 Nov;288(45):32585-98.
• 2013
  Sotomayor-Pérez AC, Subrini O, Hessel A, Ladant D, Chenal A, Molecular crowding stabilizes both the intrinsically disordered calcium-free state and the folded calcium-bound state of a repeat in toxin (RTX) protein, J. Am. Chem. Soc. 2013 Aug;135(32):11929-34.
• 2012
  Karimova G, Davi M, Ladant D, The β-lactam resistance protein Blr, a small membrane polypeptide, is a component of the Escherichia coli cell division machinery, J. Bacteriol. 2012 Oct;194(20):5576-88.
• 2012
  Ouellette SP, Karimova G, Subtil A, Ladant D, Chlamydia co-opts the rod shape-determining proteins MreB and Pbp2 for cell division, Mol. Microbiol. 2012 Jul;85(1):164-78.
• 2012
  Toledano E, Ogryzko V, Danchin A, Ladant D, Mechold U, 3′-5′ phosphoadenosine phosphate is an inhibitor of PARP-1 and a potential mediator of the lithium-dependent inhibition of PARP-1 in vivo, Biochem. J. 2012 Apr;443(2):485-90.
• 2012
  Karst JC, Barker R, Devi U, Swann MJ, Davi M, Roser SJ, Ladant D, Chenal A, Identification of a region that assists membrane insertion and translocation of the catalytic domain of Bordetella pertussis CyaA toxin, J. Biol. Chem. 2012 Mar;287(12):9200-12.
• 2012
  Sotomayor-Pérez AC, Karst JC, Ladant D, Chenal A, Mean net charge of intrinsically disordered proteins: experimental determination of protein valence by electrophoretic mobility measurements, Methods Mol. Biol. 2012;896:331-49.
• 2012
  Karst JC, Sotomayor-Pérez AC, Ladant D, Chenal A, Estimation of intrinsically disordered protein shape and time-averaged apparent hydration in native conditions by a combination of hydrodynamic methods, Methods Mol. Biol. 2012;896:163-77.
• 2011
  Robichon C, Karimova G, Beckwith J, Ladant D, Role of leucine zipper motifs in association of the Escherichia coli cell division proteins FtsL and FtsB, J. Bacteriol. 2011 Sep;193(18):4988-92.
• 2011
  Sotomayor-Pérez AC, Ladant D, Chenal A, Calcium-induced folding of intrinsically disordered repeat-in-toxin (RTX) motifs via changes of protein charges and oligomerization states, J. Biol. Chem. 2011 May;286(19):16997-7004.
• 2010
  Chenal A, Karst JC, Sotomayor Pérez AC, Wozniak AK, Baron B, England P, Ladant D, Calcium-induced folding and stabilization of the intrinsically disordered RTX domain of the CyaA toxin, Biophys. J. 2010 Dec;99(11):3744-53.
• 2010
  Fayolle C, Davi M, Dong H, Ritzel D, Le Page A, Knipping F, Majlessi L, Ladant D, Leclerc C, Induction of anti-Tat neutralizing antibodies by the CyaA vector targeting dendritic cells: influence of the insertion site and of the delivery of multicopies of the dominant Tat B-cell epitope, Vaccine 2010 Oct;28(42):6930-41.
• 2010
  Laine E, Goncalves C, Karst JC, Lesnard A, Rault S, Tang WJ, Malliavin TE, Ladant D, Blondel A, Use of allostery to identify inhibitors of calmodulin-induced activation of Bacillus anthracis edema factor, Proc. Natl. Acad. Sci. U.S.A. 2010 Jun;107(25):11277-82.
• 2010
  Sotomayor Pérez AC, Karst JC, Davi M, Guijarro JI, Ladant D, Chenal A, Characterization of the regions involved in the calcium-induced folding of the intrinsically disordered RTX motifs from the bordetella pertussis adenylate cyclase toxin, J. Mol. Biol. 2010 Mar;397(2):534-49.
• 2010
  Karst JC, Sotomayor Pérez AC, Guijarro JI, Raynal B, Chenal A, Ladant D, Calmodulin-induced conformational and hydrodynamic changes in the catalytic domain of Bordetella pertussis adenylate cyclase toxin, Biochemistry 2010 Jan;49(2):318-28.
• 2008
  Chenal A, Guijarro JI, Raynal B, Delepierre M, Ladant D, RTX calcium binding motifs are intrinsically disordered in the absence of calcium: implication for protein secretion, J. Biol. Chem. 2009 Jan;284(3):1781-9.
• 2008
  Karimova G, Robichon C, Ladant D, Characterization of YmgF, a 72-residue inner membrane protein that associates with the Escherichia coli cell division machinery, J. Bacteriol. 2009 Jan;191(1):333-46.
• 2007
  Berraondo P, Nouzé C, Préville X, Ladant D, Leclerc C, Eradication of large tumors in mice by a tritherapy targeting the innate, adaptive, and regulatory components of the immune system, Cancer Res. 2007 Sep;67(18):8847-55.
• 2006
  Bauche C, Chenal A, Knapp O, Bodenreider C, Benz R, Chaffotte A, Ladant D, Structural and functional characterization of an essential RTX subdomain of Bordetella pertussis adenylate cyclase toxin, J. Biol. Chem. 2006 Jun;281(25):16914-26.
• 2006
  Majlessi L, Simsova M, Jarvis Z, Brodin P, Rojas MJ, Bauche C, Nouzé C, Ladant D, Cole ST, Sebo P, Leclerc C, An increase in antimycobacterial Th1-cell responses by prime-boost protocols of immunization does not enhance protection against tuberculosis, Infect. Immun. 2006 Apr;74(4):2128-37.
• 2006
  Mascarell L, Bauche C, Fayolle C, Diop OM, Dupuy M, Nougarede N, Perraut R, Ladant D, Leclerc C, Delivery of the HIV-1 Tat protein to dendritic cells by the CyaA vector induces specific Th1 responses and high affinity neutralizing antibodies in non human primates, Vaccine 2006 Apr;24(17):3490-9.
• 2005
  Mascarell L, Fayolle C, Bauche C, Ladant D, Leclerc C, Induction of neutralizing antibodies and Th1-polarized and CD4-independent CD8+ T-cell responses following delivery of human immunodeficiency virus type 1 Tat protein by recombinant adenylate cyclase of Bordetella pertussis, J. Virol. 2005 Aug;79(15):9872-84.
• 2005
  Karimova G, Dautin N, Ladant D, Interaction network among Escherichia coli membrane proteins involved in cell division as revealed by bacterial two-hybrid analysis, J. Bacteriol. 2005 Apr;187(7):2233-43.
• 2005
  Préville X, Ladant D, Timmerman B, Leclerc C, Eradication of established tumors by vaccination with recombinant Bordetella pertussis adenylate cyclase carrying the human papillomavirus 16 E7 oncoprotein, Cancer Res. 2005 Jan;65(2):641-9.
• 2004
  Fayolle C, Bauche C, Ladant D, Leclerc C, Bordetella pertussis adenylate cyclase delivers chemically coupled CD8+ T-cell epitopes to dendritic cells and elicits CTL in vivo, Vaccine 2004 Dec;23(5):604-14.
• 2004
  Karimova G, Ladant D, Ullmann A, Relief of catabolite repression in a cAMP-independent catabolite gene activator mutant of Escherichia coli, Res. Microbiol. 2004 Mar;155(2):76-9.
• 2003
  Dadaglio G, Morel S, Bauche C, Moukrim Z, Lemonnier FA, Van Den Eynde BJ, Ladant D, Leclerc C, Recombinant adenylate cyclase toxin of Bordetella pertussis induces cytotoxic T lymphocyte responses against HLA*0201-restricted melanoma epitopes, Int. Immunol. 2003 Dec;15(12):1423-30.
• 2003
  Strobel H, Ladant D, Jestin JL, In vitro selection for enzymatic activity: a model study using adenylate cyclase, J. Mol. Biol. 2003 Sep;332(1):1-7.
• 2003
  Dautin N, Karimova G, Ladant D, Human immunodeficiency virus (HIV) type 1 transframe protein can restore activity to a dimerization-deficient HIV protease variant, J. Virol. 2003 Aug;77(15):8216-26.
• 2003
  El-Azami-El-Idrissi M, Bauche C, Loucka J, Osicka R, Sebo P, Ladant D, Leclerc C, Interaction of Bordetella pertussis adenylate cyclase with CD11b/CD18: Role of toxin acylation and identification of the main integrin interaction domain, J. Biol. Chem. 2003 Oct;278(40):38514-21.
• 2003
  Strobel H, Ladant D, Jestin JL, Efficient display of two enzymes on filamentous phage using an improved signal sequence, Mol. Biotechnol. 2003 May;24(1):1-10.
• 2002
  Guermonprez P, Fayolle C, Rojas MJ, Rescigno M, Ladant D, Leclerc C, In vivo receptor-mediated delivery of a recombinant invasive bacterial toxoid to CD11c + CD8 alpha -CD11bhigh dendritic cells., Eur J Immunol 2002 Nov; 32(11): 3071-81.
• 2002
  Karimova G, Ladant D, Ullmann A, Two-hybrid systems and their usage in infection biology, Int. J. Med. Microbiol. 2002 Jun;292(1):17-25.
• 2000
  Guermonprez P, Fayolle C, Karimova G, Ullmann A, Leclerc C, Ladant D, Bordetella pertussis adenylate cyclase toxin: a vehicle to deliver CD8-positive T-cell epitopes into antigen-presenting cells., Methods Enzymol 2000 ; 326(): 527-42.
• 1999
  Guermonprez P, Ladant D, Karimova G, Ullmann A, Leclerc C, Direct delivery of the Bordetella pertussis adenylate cyclase toxin to the MHC class I antigen presentation pathway., J Immunol 1999 Feb; 162(4): 1910-6.