• 2023
  Bonhomme D, Santecchia I, Escoll P, Papadopoulos S, Vernel-Pauillac F, Boneca IG, Werts C, Leptospiral lipopolysaccharide dampens inflammation through upregulation of autophagy adaptor p62 and NRF2 signaling in macrophages., Microbes Infect 2023 Dec; (): 105274.
• 2023
  Bonhomme D, Hernandez-Trejo V, Papadopoulos S, Pigache R, Fanton d'Andon M, Outlioua A, Boneca IG, Werts C, Leptospira interrogans Prevents Macrophage Cell Death and Pyroptotic IL-1β Release through Its Atypical Lipopolysaccharide., J Immunol 2023 Feb; 210(4): 459-474.
• 2022
  Cagliero J, Vernel-Pauillac F, Murray G, Adler B, Matsui M, Werts C, , Pathogenic Leptospires Limit Dendritic Cell Activation Through Avoidance of TLR4 and TRIF Signaling., Front Immunol 2022 ; 13(): 911778.
• 2022
  Santecchia I, Bonhomme D, Papadopoulos S, Escoll P, Giraud-Gatineau A, Moya-Nilges M, Vernel-Pauillac F, Boneca IG, Werts C, Alive Pathogenic and Saprophytic Leptospires Enter and Exit Human and Mouse Macrophages With No Intracellular Replication., Front Cell Infect Microbiol 2022 ; 12(): 936931.
• 2021
  Vernel-Pauillac F, Werts C, , Recent findings related to immune responses against leptospirosis and novel strategies to prevent infection., Microbes Infect ; 20(9-10): 578-588.
• 2021
  Werts C, , Interaction of Leptospira with the Innate Immune System., Curr Top Microbiol Immunol ; 415(): 163-187.
• 2021
  Werts C, , Leptospirosis: a Toll road from B lymphocytes., Chang Gung Med J ; 33(6): 591-601.
• 2021
  Vernel-Pauillac F, Murray GL, Adler B, Boneca IG, Werts C, , Anti-Leptospira immunoglobulin profiling in mice reveals strain specific IgG and persistent IgM responses associated with virulence and renal colonization., PLoS Negl Trop Dis 2021 03; 15(3): e0008970.
• 2020
  Bonhomme D, Santecchia I, Vernel-Pauillac F, Caroff M, Germon P, Murray G, Adler B, Boneca IG, Werts C, , Leptospiral LPS escapes mouse TLR4 internalization and TRIF‑associated antimicrobial responses through O antigen and associated lipoproteins., PLoS Pathog 2020 08; 16(8): e1008639.
• 2020
  Holzapfel M, Bonhomme D, Cagliero J, Vernel-Pauillac F, Fanton d'Andon M, Bortolussi S, Fiette L, Goarant C, Wunder EA, Picardeau M, Ko AI, Werling D, Matsui M, Boneca IG, Werts C, , Escape of TLR5 Recognition by Leptospira spp.: A Rationale for Atypical Endoflagella., Front Immunol 2020 ; 11(): 2007.
• 2020
  Santecchia I, Ferrer MF, Vieira ML, Gómez RM, Werts C, , Phagocyte Escape of Leptospira: The Role of TLRs and NLRs., Front Immunol 2020 ; 11(): 571816.
• 2020
  Nair N, Guedes MS, Hajjar AM, Werts C, Gomes-Solecki M, , Role of TLR4 in Persistent Leptospira interrogans Infection: A Comparative In Vivo Study in Mice., Front Immunol 2020 ; 11(): 572999.
• 2020
  Bonhomme D, Werts C, , Purification of LPS from Leptospira., Methods Mol Biol 2020 ; 2134(): 53-65.
• 2020
  Vernel-Pauillac F, Werts C, , In Vivo Imaging of Bioluminescent Leptospires., Methods Mol Biol 2020 ; 2134(): 149-160.
• 2020
  Nair N, Guedes MS, Werts C, Gomes-Solecki M, , The route of infection with Leptospira interrogans serovar Copenhageni affects the kinetics of bacterial dissemination and kidney colonization., PLoS Negl Trop Dis 2020 01; 14(1): e0007950.
• 2019
  Santecchia I, Vernel-Pauillac F, Rasid O, Quintin J, Gomes-Solecki M, Boneca IG, Werts C, , Innate immune memory through TLR2 and NOD2 contributes to the control of Leptospira interrogans infection., PLoS Pathog 2019 05; 15(5): e1007811.
• 2018
  Oldenburg R, Mayau V, Prandi J, Arbues A, Astarie-Dequeker C, Guilhot C, Werts C, Winter N, Demangel C, , Mycobacterial Phenolic Glycolipids Selectively Disable TRIF-Dependent TLR4 Signaling in Macrophages., Front Immunol 2018 ; 9(): 2.
• 2017
  Ratet G, Santecchia I, Fanton d'Andon M, Vernel-Pauillac F, Wheeler R, Lenormand P, Fischer F, Lechat P, Haake DA, Picardeau M, Boneca IG, Werts C, , LipL21 lipoprotein binding to peptidoglycan enables Leptospira interrogans to escape NOD1 and NOD2 recognition., PLoS Pathog 2017 12; 13(12): e1006725.
• 2017
  Potula HH, Richer L, Werts C, Gomes-Solecki M, , Pre-treatment with Lactobacillus plantarum prevents severe pathogenesis in mice infected with Leptospira interrogans and may be associated with recruitment of myeloid cells., PLoS Negl Trop Dis 2017 Aug; 11(8): e0005870.
• 2017
  Dahan J, Levillayer F, Xia T, Nouët Y, Werts C, Fanton d'Andon M, Adib-Conquy M, Cassard-Doulcier AM, Khanna V, Chen J, Tordjmann T, Buendia MA, Jouvion G, Wei Y, , LIM-Only Protein FHL2 Is a Negative Regulator of Transforming Growth Factor β1 Expression., Mol Cell Biol 2017 05; 37(10): .
• 2017
  Gomes-Solecki M, Santecchia I, Werts C, , Animal Models of Leptospirosis: Of Mice and Hamsters., Front Immunol 2017 ; 8(): 58.
• 2015
  Guesdon W, Auray G, Pezier T, Bussière FI, Drouet F, Le Vern Y, Marquis M, Potiron L, Rabot S, Bruneau A, Werts C, Laurent F, Lacroix-Lamandé S, , CCL20 Displays Antimicrobial Activity Against Cryptosporidium parvum, but Its Expression Is Reduced During Infection in the Intestine of Neonatal Mice., J Infect Dis 2015 Oct; 212(8): 1332-40.
• 2015
  Veyrier FJ, Biais N, Morales P, Belkacem N, Guilhen C, Ranjeva S, Sismeiro O, Péhau-Arnaudet G, Rocha EP, Werts C, Taha MK, Boneca IG, , Common Cell Shape Evolution of Two Nasopharyngeal Pathogens., PLoS Genet 2015 Jul; 11(7): e1005338.
• 2014
  Ratet G, Veyrier FJ, Fanton d'Andon M, Kammerscheit X, Nicola MA, Picardeau M, Boneca IG, Werts C, , Live imaging of bioluminescent leptospira interrogans in mice reveals renal colonization as a stealth escape from the blood defenses and antibiotics., PLoS Negl Trop Dis 2014 Dec; 8(12): e3359.
• 2014
  Bens M, Vimont S, Ben Mkaddem S, Chassin C, Goujon JM, Balloy V, Chignard M, Werts C, Vandewalle A, Flagellin/TLR5 signalling activates renal collecting duct cells and facilitates invasion and cellular translocation of uropathogenic Escherichia coli, Cell. Microbiol. 2014 Oct;16(10):1503-17.
• 2014
  Vandewalle A, Tourneur E, Bens M, Chassin C, Werts C, Calcineurin/NFAT signaling and innate host defence: a role for NOD1-mediated phagocytic functions, Cell Commun. Signal 2014;12:8.
• 2014
  Fanton d'Andon M, Quellard N, Fernandez B, Ratet G, Lacroix-Lamandé S, Vandewalle A, Boneca IG, Goujon JM, Werts C, , Leptospira Interrogans induces fibrosis in the mouse kidney through Inos-dependent, TLR- and NLR-independent signaling pathways., PLoS Negl Trop Dis 2014 ; 8(1): e2664.
• 2013
  Lantier L, Drouet F, Guesdon W, Mancassola R, Metton C, Lo-Man R, Werts C, Laurent F, Lacroix-Lamandé S, Poly(I:C)-induced protection of neonatal mice against intestinal Cryptosporidium parvum infection requires an additional TLR5 signal provided by the gut flora, J. Infect. Dis. 2014 Feb;209(3):457-67.
• 2013
  Dahan J, Nouët Y, Jouvion G, Levillayer F, Adib-Conquy M, Cassard-Doulcier AM, Tebbi A, Blanc F, Remy L, Chen J, Cairo S, Werts C, Si-Tahar M, Tordjmann T, Buendia MA, Wei Y, , LIM-only protein FHL2 activates NF-κB signaling in the control of liver regeneration and hepatocarcinogenesis., Mol Cell Biol 2013 Aug; 33(16): 3299-308.
• 2013
  Zarantonelli ML, Skoczynska A, Antignac A, El Ghachi M, Deghmane AE, Szatanik M, Mulet C, Werts C, Peduto L, d'Andon MF, Thouron F, Nato F, Lebourhis L, Philpott DJ, Girardin SE, Vives FL, Sansonetti P, Eberl G, Pedron T, Taha MK, Boneca IG, , Penicillin resistance compromises Nod1-dependent proinflammatory activity and virulence fitness of neisseria meningitidis., Cell Host Microbe 2013 Jun; 13(6): 735-45.
• 2013
  Tourneur E, Ben Mkaddem S, Chassin C, Bens M, Goujon JM, Charles N, Pellefigues C, Aloulou M, Hertig A, Monteiro RC, Girardin SE, Philpott DJ, Rondeau E, Elbim C, Werts C, Vandewalle A, Cyclosporine A impairs nucleotide binding oligomerization domain (Nod1)-mediated innate antibacterial renal defenses in mice and human transplant recipients, PLoS Pathog. 2013 Jan;9(1):e1003152.
• 2013
  Lantier L, Lacroix-Lamandé S, Potiron L, Metton C, Drouet F, Guesdon W, Gnahoui-David A, Le Vern Y, Deriaud E, Fenis A, Rabot S, Descamps A, Werts C, Laurent F, , Intestinal CD103+ dendritic cells are key players in the innate immune control of Cryptosporidium parvum infection in neonatal mice., PLoS Pathog 2013 ; 9(12): e1003801.
• 2012
  Bonis M, Williams A, Guadagnini S, Werts C, Boneca IG, , The effect of bulgecin A on peptidoglycan metabolism and physiology of Helicobacter pylori., Microb Drug Resist 2012 Jun; 18(3): 230-9.
• 2012
  Lacroix-Lamandé S, d'Andon MF, Michel E, Ratet G, Philpott DJ, Girardin SE, Boneca IG, Vandewalle A, Werts C, , Downregulation of the Na/K-ATPase pump by leptospiral glycolipoprotein activates the NLRP3 inflammasome., J Immunol 2012 Mar; 188(6): 2805-14.
• 2011
  Werts C, Rubino S, Ling A, Girardin SE, Philpott DJ, , Nod-like receptors in intestinal homeostasis, inflammation, and cancer., J Leukoc Biol 2011 Sep; 90(3): 471-82.
• 2010
  Foureau DM, Mielcarz DW, Menard LC, Schulthess J, Werts C, Vasseur V, Ryffel B, Kasper LH, Buzoni-Gatel D, TLR9-dependent induction of intestinal alpha-defensins by Toxoplasma gondii, J. Immunol. 2010 Jun;184(12):7022-9.
• 2010
  Ben Mkaddem S, Pedruzzi E, Werts C, Coant N, Bens M, Cluzeaud F, Goujon JM, Ogier-Denis E, Vandewalle A, Heat shock protein gp96 and NAD(P)H oxidase 4 play key roles in Toll-like receptor 4-activated apoptosis during renal ischemia/reperfusion injury, Cell Death Differ. 2010 Sep;17(9):1474-85.
• 2009
  Chassin C, Picardeau M, Goujon JM, Bourhy P, Quellard N, Darche S, Badell E, d'Andon MF, Winter N, Lacroix-Lamandé S, Buzoni-Gatel D, Vandewalle A, Werts C, TLR4- and TLR2-mediated B cell responses control the clearance of the bacterial pathogen, Leptospira interrogans, J. Immunol. 2009 Aug;183(4):2669-77.
• 2009
  Mkaddem SB, Werts C, Goujon JM, Bens M, Pedruzzi E, Ogier-Denis E, Vandewalle A, Heat shock protein gp96 interacts with protein phosphatase 5 and controls toll-like receptor 2 (TLR2)-mediated activation of extracellular signal-regulated kinase (ERK) 1/2 in post-hypoxic kidney cells, J. Biol. Chem. 2009 May;284(18):12541-9.
• 2008
  Bouskra D, Brézillon C, Bérard M, Werts C, Varona R, Boneca IG, Eberl G, , Lymphoid tissue genesis induced by commensals through NOD1 regulates intestinal homeostasis., Nature 2008 Nov; 456(7221): 507-10.
• 2008
  Hitotsumatsu O, Ahmad RC, Tavares R, Wang M, Philpott D, Turer EE, Lee BL, Shiffin N, Advincula R, Malynn BA, Werts C, Ma A, The ubiquitin-editing enzyme A20 restricts nucleotide-binding oligomerization domain containing 2-triggered signals, Immunity 2008 Mar;28(3):381-90.
• 2008
  Buzoni-Gatel D, Dubremetz JF, Werts C, , [Molecular cross talk between Toxoplasma gondii and the host immune system]., Med Sci (Paris) 2008 Feb; 24(2): 191-6.
• 2007
  Werts C, le Bourhis L, Liu J, Magalhaes JG, Carneiro LA, Fritz JH, Stockinger S, Balloy V, Chignard M, Decker T, Philpott DJ, Ma X, Girardin SE, , Nod1 and Nod2 induce CCL5/RANTES through the NF-kappaB pathway., Eur J Immunol 2007 Sep; 37(9): 2499-508.
• 2007
  Bourhis LL, Werts C, , Role of Nods in bacterial infection., Microbes Infect 2007 Apr; 9(5): 629-36.
• 2007
  Tirsoaga A, Novikov A, Adib-Conquy M, Werts C, Fitting C, Cavaillon JM, Caroff M, Simple method for repurification of endotoxins for biological use, Appl. Environ. Microbiol. 2007 Mar;73(6):1803-8.
• 2006
  Chassin C, Goujon JM, Darche S, du Merle L, Bens M, Cluzeaud F, Werts C, Ogier-Denis E, Le Bouguénec C, Buzoni-Gatel D, Vandewalle A, Renal collecting duct epithelial cells react to pyelonephritis-associated Escherichia coli by activating distinct TLR4-dependent and -independent inflammatory pathways, J. Immunol. 2006 Oct;177(7):4773-84.
• 2006
  Buzoni-Gatel D, Werts C, , Toxoplasma gondii and subversion of the immune system., Trends Parasitol 2006 Oct; 22(10): 448-52.
• 2006
  Chaput C, Ecobichon C, Cayet N, Girardin SE, Werts C, Guadagnini S, Prévost MC, Mengin-Lecreulx D, Labigne A, Boneca IG, , Role of AmiA in the morphological transition of Helicobacter pylori and in immune escape., PLoS Pathog 2006 Sep; 2(9): e97.
• 2006
  Werts C, Girardin SE, Philpott DJ, TIR, CARD and PYRIN: three domains for an antimicrobial triad, Cell Death Differ. 2006 May;13(5):798-815.
• 2005
  Nahori MA, Fournié-Amazouz E, Que-Gewirth NS, Balloy V, Chignard M, Raetz CR, Saint Girons I, Werts C, , Differential TLR recognition of leptospiral lipid A and lipopolysaccharide in murine and human cells., J Immunol 2005 Nov; 175(9): 6022-31.
• 2005
  Netea MG, Ferwerda G, de Jong DJ, Werts C, Boneca IG, Jéhanno M, Van Der Meer JW, Mengin-Lecreulx D, Sansonetti PJ, Philpott DJ, Dharancy S, Girardin SE, The frameshift mutation in Nod2 results in unresponsiveness not only to Nod2- but also Nod1-activating peptidoglycan agonists, J. Biol. Chem. 2005 Oct;280(43):35859-67.
• 2005
  Fritz JH, Girardin SE, Fitting C, Werts C, Mengin-Lecreulx D, Caroff M, Cavaillon JM, Philpott DJ, Adib-Conquy M, , Synergistic stimulation of human monocytes and dendritic cells by Toll-like receptor 4 and NOD1- and NOD2-activating agonists., Eur J Immunol 2005 Aug; 35(8): 2459-70.
• 2004
  Travassos LH, Girardin SE, Philpott DJ, Blanot D, Nahori MA, Werts C, Boneca IG, , Toll-like receptor 2-dependent bacterial sensing does not occur via peptidoglycan recognition., EMBO Rep 2004 Oct; 5(10): 1000-6.
• 2004
  Que-Gewirth NL, Ribeiro AA, Kalb SR, Cotter RJ, Bulach DM, Adler B, Girons IS, Werts C, Raetz CR, A methylated phosphate group and four amide-linked acyl chains in leptospira interrogans lipid A. The membrane anchor of an unusual lipopolysaccharide that activates TLR2, J. Biol. Chem. 2004 Jun;279(24):25420-9.
• 2004
  Sweet CR, Williams AH, Karbarz MJ, Werts C, Kalb SR, Cotter RJ, Raetz CR, Enzymatic synthesis of lipid A molecules with four amide-linked acyl chains. LpxA acyltransferases selective for an analog of UDP-N-acetylglucosamine in which an amine replaces the 3″-hydroxyl group, J. Biol. Chem. 2004 Jun;279(24):25411-9.
• 2004
  Gobert AP, Bambou JC, Werts C, Balloy V, Chignard M, Moran AP, Ferrero RL, , Helicobacter pylori heat shock protein 60 mediates interleukin-6 production by macrophages via a toll-like receptor (TLR)-2-, TLR-4-, and myeloid differentiation factor 88-independent mechanism., J Biol Chem 2004 Jan; 279(1): 245-50.
• 2003
  Adib-Conquy M, Moine P, Asehnoune K, Edouard A, Espevik T, Miyake K, Werts C, Cavaillon JM, , Toll-like receptor-mediated tumor necrosis factor and interleukin-10 production differ during systemic inflammation., Am J Respir Crit Care Med 2003 Jul; 168(2): 158-64.
• 2003
  Ait-Said F, Elalamy I, Werts C, Gomard MT, Jacquemin C, Couetil JP, Hatmi M, , Inhibition by eicosapentaenoic acid of IL-1beta-induced PGHS-2 expression in human microvascular endothelial cells: involvement of lipoxygenase-derived metabolites and p38 MAPK pathway., Biochim Biophys Acta 2003 Feb; 1631(1): 77-84.
• 2002
  Said FA, Werts C, Elalamy I, Couetil JP, Jacquemin C, Hatmi M, , TNF-alpha, inefficient by itself, potentiates IL-1beta-induced PGHS-2 expression in human pulmonary microvascular endothelial cells: requirement of NF-kappaB and p38 MAPK pathways., Br J Pharmacol 2002 Aug; 136(7): 1005-14.
• 2001
  Brenot A, Werts C, Ottone C, Sertour N, Charon NW, Postic D, Baranton G, Saint Girons I, First evidence for a restriction-modification system in Leptospira sp, FEMS Microbiol. Lett. 2001 Jul;201(2):139-43.
• 2001
  Werts C, Tapping RI, Mathison JC, Chuang TH, Kravchenko V, Saint Girons I, Haake DA, Godowski PJ, Hayashi F, Ozinsky A, Underhill DM, Kirschning CJ, Wagner H, Aderem A, Tobias PS, Ulevitch RJ, Leptospiral lipopolysaccharide activates cells through a TLR2-dependent mechanism, Nat. Immunol. 2001 Apr;2(4):346-52.
• 1994
  Charbit A, Werts C, Michel V, Klebba PE, Quillardet P, Hofnung M, A role for residue 151 of LamB in bacteriophage lambda adsorption: possible steric effect of amino acid substitutions, J. Bacteriol. 1994 Jun;176(11):3204-9.
• 1994
  Werts C, Michel V, Hofnung M, Charbit A, Adsorption of bacteriophage lambda on the LamB protein of Escherichia coli K-12: point mutations in gene J of lambda responsible for extended host range, J. Bacteriol. 1994 Feb;176(4):941-7.
• 1993
  Werts C, Charbit A, Construction and first characterization of two reciprocal hybrids between LamB from Escherichia coli K12 and Klebsiella pneumoniae, Res. Microbiol. 1993 May;144(4):259-69.
• 1993
  Werts C, O'Callaghan D, Hofnung M, Charbit A, Immunological relatedness of the LamB proteins among members of Enterobacteriaceae, J. Gen. Microbiol. 1993 Apr;139(4):881-7.
• 1992
  Werts C, Charbit A, Bachellier S, Hofnung M, DNA sequence analysis of the lamB gene from Klebsiella pneumoniae: implications for the topology and the pore functions in maltoporin, Mol. Gen. Genet. 1992 Jun;233(3):372-8.
• 1991
  Martineau P, Charbit A, Leclerc C, Werts C, O'Callaghan D, Hofnung M, A genetic system to elicit and monitor antipeptide antibodies without peptide synthesis, Biotechnology (N.Y.) 1991 Feb;9(2):170-2.
• 1991
  Charbit A, Ronco J, Michel V, Werts C, Hofnung M, Permissive sites and topology of an outer membrane protein with a reporter epitope, J. Bacteriol. 1991 Jan;173(1):262-75.