• 2025
  Ravneet Kaur Sidhu, Guillem Mas Fiol, Pierre Lê-Bury, Christian E Demeure, Emelyne Bougit, Rémi Beau, Charlotte Balière, Aurelia Kwasiborski, Valérie Caro, Jennifer Klunk, Daniel J Salkeld, Ann Carmichael, Nükhet Varlık, Debi Poinar, David J D Earn, Benjamin M Bolker, Jonathan Dushoff, G Brian Golding, Nicolas Rascovan, Olivier Dussurget, Edward C Holmes, Javier Pizarro-Cerdá, Hendrik N Poinar, Attenuation of virulence in Yersinia pestis across three plague pandemics, Science, 2025, 388 (6750), pp.eadt3880. ⟨10.1126/science.adt3880⟩.
• 2025
  Tauras P Vilgalys, Jennifer Klunk, Christian E Demeure, Xiaoheng Cheng, Mari Shiratori, Julien Madej, Rémi Beau, Derek Elli, Maria I Patino, Rebecca Redfern, Sharon N Dewitte, Julia A Gamble, Jesper L Boldsen, Ann Carmichael, Nükhet Varlik, Katherine Eaton, Jean-Christophe Grenier, G. Brian Golding, Alison Devault, Jean-Marie Rouillard, Vania Yotova, Renata Sindeaux, Chun Jimmie Ye, Matin Bikaran, Anne Dumaine, Jessica F Brinkworth, Dominique Missiakas, Guy A Rouleau, Matthias Steinrücken, Javier Pizarro-Cerdá, Hendrik N Poinar, Luis B Barreiro, Reply to: Insufficient evidence for natural selection associated with the Black Death, Nature, 2025, 638 (8051), pp.E23. ⟨10.1038/s41586-024-08497-4⟩.
• 2025
  Vilgalys TP, Klunk J, Demeure CE, Cheng X, Shiratori M, Madej J, Beau R, Elli D, Patino MI, Redfern R, DeWitte SN, Gamble JA, Boldsen JL, Carmichael A, Varlik N, Eaton K, Grenier JC, Golding GB, Devault A, Rouillard JM, Yotova V, Sindeaux R, Ye CJ, Bikaran M, Dumaine A, Brinkworth JF, Missiakas D, Rouleau GA, Steinrücken M, Pizarro-Cerdá J, Poinar HN, Barreiro LB, Reply to: Insufficient evidence for natural selection associated with the Black Death., Nature 2025 Feb; 638(8051): E23-E29.
• 2025
  Jennifer Klunk, Tauras P Vilgalys, Christian E Demeure, Xiaoheng Cheng, Mari Shiratori, Julien Madej, Rémi Beau, Derek Elli, Maria I Patino, Rebecca Redfern, Sharon N Dewitte, Julia A Gamble, Jesper L Boldsen, Ann Carmichael, Nükhet Varlik, Katherine Eaton, Jean-Christophe Grenier, G. Brian Golding, Alison Devault, Jean-Marie Rouillard, Vania Yotova, Renata Sindeaux, Chun Jimmie Ye, Matin Bikaran, Anne Dumaine, Jessica F Brinkworth, Dominique Missiakas, Guy A Rouleau, Matthias Steinrücken, Javier Pizarro-Cerdá, Hendrik N Poinar, Luis B Barreiro, Author Correction: Evolution of immune genes is associated with the Black Death, Nature, 2025, 637 (8048), pp.E30. ⟨10.1038/s41586-024-08522-6⟩.
• 2025
  Klunk J, Vilgalys TP, Demeure CE, Cheng X, Shiratori M, Madej J, Beau R, Elli D, Patino MI, Redfern R, DeWitte SN, Gamble JA, Boldsen JL, Carmichael A, Varlik N, Eaton K, Grenier JC, Golding GB, Devault A, Rouillard JM, Yotova V, Sindeaux R, Ye CJ, Bikaran M, Dumaine A, Brinkworth JF, Missiakas D, Rouleau GA, Steinrücken M, Pizarro-Cerdá J, Poinar HN, Barreiro LB, Author Correction: Evolution of immune genes is associated with the Black Death., Nature 2025 Jan; 637(8048): E30.
• 2023
  Vilgalys TP, Klunk J, Demeure CE, Cheng X, Shiratori M, Madej J, Beau R, Elli D, Patino MI, Redfern R, DeWitte SN, Gamble JA, Boldsen JL, Carmichael A, Varlik N, Eaton K, Grenier JC, Golding GB, Devault A, Rouillard JM, Yotova V, Sindeaux R, Ye CJ, Bikaran M, Dumaine A, Brinkworth JF, Missiakas D, Rouleau GA, Steinrücken M, Pizarro-Cerdá J, Poinar HN, Barreiro LB, , Reply to Barton et al: signatures of natural selection during the Black Death., bioRxiv 2023 Apr; (): .
• 2023
  Demeure CE, Poinar H, Barreiro L, Pizarro-Cerdá J, , [The Black Death, natural selection and susceptibility to auto-immune disorders]., Med Sci (Paris) 2023 Apr; 39(4): 331-333.
• 2023
  Guillem Mas Fiol, C Demeure, Anne-Sophie Le Guern, Javier Pizarro-Cerdá, Yersinia pestis and plague in the 21st century: learning from a distant past, The Biochemist, 2023, 45 (2), pp.1-5. ⟨10.1042/bio_2023_109⟩.
• 2022
  Klunk J, Vilgalys TP, Demeure CE, Cheng X, Shiratori M, Madej J, Beau R, Elli D, Patino MI, Redfern R, DeWitte SN, Gamble JA, Boldsen JL, Carmichael A, Varlik N, Eaton K, Grenier JC, Golding GB, Devault A, Rouillard JM, Yotova V, Sindeaux R, Ye CJ, Bikaran M, Dumaine A, Brinkworth JF, Missiakas D, Rouleau GA, Steinrücken M, Pizarro-Cerdá J, Poinar HN, Barreiro LB, , Evolution of immune genes is associated with the Black Death., Nature 2022 Nov; 611(7935): 312-319.
• 2022
  Savin C, Le Guern AS, Chereau F, Guglielmini J, Heuzé G, Demeure C, Pizarro-Cerdá J, , First Description of a Yersinia pseudotuberculosis Clonal Outbreak in France, Confirmed Using a New Core Genome Multilocus Sequence Typing Method., Microbiol Spectr 2022 Jul; (): e0114522.
• 2020
  Andrianaivoarimanana V, Iharisoa AL, Rahalison L, Ralimanantsoa ML, Ratsitorahina M, Rakotonanahary RJL, Carniel E, Demeure C, Rajerison M, , Short- and long-term humoral immune response against Yersinia pestis in plague patients, Madagascar., BMC Infect Dis 2020 Nov; 20(1): 822.
• 2020
  Vallès X, Stenseth NC, Demeure C, Horby P, Mead PS, Cabanillas O, Ratsitorahina M, Rajerison M, Andrianaivoarimanana V, Ramasindrazana B, Pizarro-Cerda J, Scholz HC, Girod R, Hinnebusch BJ, Vigan-Womas I, Fontanet A, Wagner DM, Telfer S, Yazdanpanah Y, Tortosa P, Carrara G, Deuve J, Belmain SR, D'Ortenzio E, Baril L, Human plague: An old scourge that needs new answers., PLoS Negl Trop Dis 2020 Aug; 14(8): e0008251.
• 2020
  Derbise A, Guillas C, Gerke C, Carniel E, Pizarro-Cerdà J, Demeure CE, Subcutaneous vaccination with a live attenuated Yersinia pseudotuberculosis plague vaccine, Vaccine 2020 Jan;.
• 2019
  Laurence Baril, Xavier Vallès , Nils Christian Stenseth, Minoarisoa Rajerison, Maherisoa Ratsitorahina, Javier Pizarro-Cerdá, Christian Demeure, Steve Belmain, Holger Scholz, Romain Girod, Joseph Hinnebusch, Ines Vigan-Womas, Eric Bertherat, Arnaud Fontanet, Yazdan Yazadanpanah, Guia Carrara, Jane Deuve, Eric D'ortenzio, Jose Oswaldo Cabanillas Angulo, Paul Mead, Peter W Horby, Can we make human plague history? A call to action, BMJ Global Health 2019;4:e001984. doi:10.1136/ bmjgh-2019-001984.
• 2019
  Christian E. Demeure, Olivier Dussurget, Guillem Mas Fiol, Anne-Sophie Le Guern, Cyril Savin, Javier Pizarro-Cerdá, Yersinia pestis and plague: an updated view on evolution, virulence determinants, immune subversion, vaccination, and diagnostics, Genes and Immunity, 2019, 20 (5), pp.357-370. ⟨10.1038/s41435-019-0065-0⟩.
• 2019
  Christian E. Demeure, Olivier Dussurget, Guillem Mas Fiol, Anne-Sophie Le Guern, Cyril Savin, Javier Pizarro-Cerdá, Yersinia pestis and plague: an updated view on evolution, virulence determinants, immune subversion, vaccination and diagnostics, Microbes and Infection, 2019, 21 (5-6), pp.202-212. ⟨10.1016/j.micinf.2019.06.007⟩.
• 2018
  Demeure CE, Derbise A, Guillas C, Gerke C, Cauchemez S, Carniel E, Pizarro-Cerdá J, , Humoral and cellular immune correlates of protection against bubonic plague by a live Yersinia pseudotuberculosis vaccine., Vaccine 2019 01; 37(1): 123-129.
• 2017
  Emilia Pachulec, Rym Ben Abdelwahed Bagga, Lucie Chevallier, Hope O'Donnell, Chloé Guillas, Jean Jaubert, Xavier Montagutelli, Elisabeth Carniel, Christian E. Demeure, Enhanced Macrophage M1 Polarization and Resistance to Apoptosis Enable Resistance to Plague, Journal of Infectious Diseases, 2017, 216 (6), pp.761-770. ⟨10.1093/infdis/jix348⟩.
• 2016
  Demeure CE, Derbise A, Carniel E, Oral vaccination against plague using Yersinia pseudotuberculosis, Chem. Biol. Interact. 2016 Apr;.
• 2015
  Derbise A, Hanada Y, Khalifé M, Carniel E, Demeure CE, Complete Protection against Pneumonic and Bubonic Plague after a Single Oral Vaccination, PLoS Negl Trop Dis 2015 Oct;9(10):e0004162.
• 2013
  Simon S, Demeure C, Lamourette P, Filali S, Plaisance M, Créminon C, Volland H, Carniel E, Fast and simple detection of Yersinia pestis applicable to field investigation of plague foci, PLoS ONE 2013;8(1):e54947.
• 2012
  Lucie Chevallier, Charlène Blanchet, Jean Jaubert, Emilia Pachulec, Christian E. Demeure, Elisabeth Carniel, Jean-Jacques Panthier, Xavier Montagutelli, Resistance to plague of Mus spretus SEG/Pas mice requires the combined action of at least four genetic factors, Genes and Immunity, 2013, 14 (1), pp.35-41. ⟨10.1038/gene.2012.50⟩.
• 2012
  Derbise A, Cerdà Marín A, Ave P, Blisnick T, Huerre M, Carniel E, Demeure CE, An encapsulated Yersinia pseudotuberculosis is a highly efficient vaccine against pneumonic plague, PLoS Negl Trop Dis 2012;6(2):e1528.
• 2012
  Christian Demeure, Live vaccines against Plague and Pseudotuberculosis, Yersinia - Systems Biology and Control. 2012. Chap. 10: 143-168.
• 2011
  Christian E. Demeure, Charlène Blanchet, Catherine Fitting, Corinne Fayolle, Huot Khun, Marek Szatanik, Geneviève Milon, Jean-Jacques Panthier, Jean Jaubert, Xavier Montagutelli, Michel Huerre, Jean-Marc Cavaillon, Elisabeth Carniel, Early Systemic Bacterial Dissemination and a Rapid Innate Immune Response Characterize Genetic Resistance to Plague of SEG Mice, Journal of Infectious Diseases, 2012, 205 (1), pp.134-143. ⟨10.1093/infdis/jir696⟩.
• 2010
  Derbise A, Chenal-Francisque V, Huon C, Fayolle C, Demeure CE, Chane-Woon-Ming B, Médigue C, Hinnebusch BJ, Carniel E, Delineation and analysis of chromosomal regions specifying Yersinia pestis, Infect. Immun. 2010 Sep;78(9):3930-41.
• 2010
  Quintard B, Petit T, Ruvoen N, Carniel E, Demeure CE, Efficacy of an oral live vaccine for veterinary use against pseudotuberculosis, Comp. Immunol. Microbiol. Infect. Dis. 2010 Dec;33(6):e59-65.
• 2008
  Blisnick T, Ave P, Huerre M, Carniel E, Demeure CE, Oral vaccination against bubonic plague using a live avirulent Yersinia pseudotuberculosis strain, Infect. Immun. 2008 Aug;76(8):3808-16.
• 2005
  Demeure CE, Brahimi K, Hacini F, Marchand F, Péronet R, Huerre M, St-Mezard P, Nicolas JF, Brey P, Delespesse G, Mécheri S, Anopheles mosquito bites activate cutaneous mast cells leading to a local inflammatory response and lymph node hyperplasia, J. Immunol. 2005 Apr;174(7):3932-40.
• 2003
  Skokos D, Botros HG, Demeure C, Morin J, Peronet R, Birkenmeier G, Boudaly S, Mécheri S, Mast cell-derived exosomes induce phenotypic and functional maturation of dendritic cells and elicit specific immune responses in vivo, J. Immunol. 2003 Mar;170(6):3037-45.
• 2001
  Demeure CE, Wolfers J, Martin-Garcia N, Gaulard P, Triebel F, T Lymphocytes infiltrating various tumour types express the MHC class II ligand lymphocyte activation gene-3 (LAG-3): role of LAG-3/MHC class II interactions in cell-cell contacts, Eur. J. Cancer 2001 Sep;37(13):1709-18.
• 2001
  Latour S, Tanaka H, Demeure C, Mateo V, Rubio M, Brown EJ, Maliszewski C, Lindberg FP, Oldenborg A, Ullrich A, Delespesse G, Sarfati M, Bidirectional negative regulation of human T and dendritic cells by CD47 and its cognate receptor signal-regulator protein-alpha: down-regulation of IL-12 responsiveness and inhibition of dendritic cell activation, J. Immunol. 2001 Sep;167(5):2547-54.
• 2000
  Tanaka H, Demeure CE, Rubio M, Delespesse G, Sarfati M, Human monocyte-derived dendritic cells induce naive T cell differentiation into T helper cell type 2 (Th2) or Th1/Th2 effectors. Role of stimulator/responder ratio, J. Exp. Med. 2000 Aug;192(3):405-12.
• 2000
  Demeure CE, Tanaka H, Mateo V, Rubio M, Delespesse G, Sarfati M, CD47 engagement inhibits cytokine production and maturation of human dendritic cells, J. Immunol. 2000 Feb;164(4):2193-9.
• 1999
  Ohshima Y, Yang LP, Avice MN, Kurimoto M, Nakajima T, Sergerie M, Demeure CE, Sarfati M, Delespesse G, Naive human CD4+ T cells are a major source of lymphotoxin alpha, J. Immunol. 1999 Apr;162(7):3790-4.
• 1999
  Avice MN, Sarfati M, Triebel F, Delespesse G, Demeure CE, Lymphocyte activation gene-3, a MHC class II ligand expressed on activated T cells, stimulates TNF-alpha and IL-12 production by monocytes and dendritic cells, J. Immunol. 1999 Mar;162(5):2748-53.
• 1999
  Delespesse G, Ohshima Y, Yang LP, Demeure C, Sarfati M, OX40-Mediated cosignal enhances the maturation of naive human CD4+ T cells into high IL-4-producing effectors, Int. Arch. Allergy Immunol. 1999 Feb-Apr;118(2-4):384-6.
• 1998
  Avice MN, Demeure CE, Delespesse G, Rubio M, Armant M, Sarfati M, IL-15 promotes IL-12 production by human monocytes via T cell-dependent contact and may contribute to IL-12-mediated IFN-gamma secretion by CD4+ T cells in the absence of TCR ligation, J. Immunol. 1998 Oct;161(7):3408-15.
• 1998
  Delespesse G, Yang LP, Ohshima Y, Demeure C, Shu U, Byun DG, Sarfati M, Maturation of human neonatal CD4+ and CD8+ T lymphocytes into Th1/Th2 effectors, Vaccine 1998 Aug-Sep;16(14-15):1415-9.
• 1997
  Demeure CE, Yang LP, Desjardins C, Raynauld P, Delespesse G, Prostaglandin E2 primes naive T cells for the production of anti-inflammatory cytokines, Eur. J. Immunol. 1997 Dec;27(12):3526-31.
• 1997
  Delespesse G, Demeure CE, Yang LP, Ohshima Y, Byun DG, Shu U, In vitro maturation of naive human CD4+ T lymphocytes into Th1, Th2 effectors, Int. Arch. Allergy Immunol. 1997 May-Jul;113(1-3):157-9.
• 1996
  Vezzio N, Sarfati M, Yang LP, Demeure CE, Delespesse G, Human Th2-like cell clones induce IL-12 production by dendritic cells and may express several cytokine profiles, Int. Immunol. 1996 Dec;8(12):1963-70.
• 1996
  Delespesse G, Yang LP, Shu U, Byun DG, Demeure CE, Ohshima Y, Wu CY, Sarfati M, Role of interleukin-12 in the maturation of naive human CD4 T cells, Ann. N. Y. Acad. Sci. 1996 Oct;795:196-201.
• 1996
  Demeure CE, Byun DG, Yang LP, Vezzio N, Delespesse G, CD31 (PECAM-1) is a differentiation antigen lost during human CD4 T-cell maturation into Th1 or Th2 effector cells, Immunology 1996 May;88(1):110-5.
• 1995
  Yang LP, Demeure CE, Byun DG, Vezzio N, Delespesse G, Maturation of neonatal human CD4 T cells: III. Role of B7 co-stimulation at priming, Int. Immunol. 1995 Dec;7(12):1987-93.
• 1995
  Yang LP, Byun DG, Demeure CE, Vezzio N, Delespesse G, Default development of cloned human naive CD4 T cells into interleukin-4- and interleukin-5- producing effector cells, Eur. J. Immunol. 1995 Dec;25(12):3517-20.
• 1995
  Demeure CE, Yang LP, Byun DG, Ishihara H, Vezzio N, Delespesse G, Human naive CD4 T cells produce interleukin-4 at priming and acquire a Th2 phenotype upon repetitive stimulations in neutral conditions, Eur. J. Immunol. 1995 Sep;25(9):2722-5.
• 1994
  Byun DG, Demeure CE, Yang LP, Shu U, Ishihara H, Vezzio N, Gately MK, Delespesse G, In vitro maturation of neonatal human CD8 T lymphocytes into IL-4- and IL-5-producing cells, J. Immunol. 1994 Dec;153(11):4862-71.
• 1994
  Shu U, Demeure CE, Byun DG, Podlaski F, Stern AS, Delespesse G, Interleukin 12 exerts a differential effect on the maturation of neonatal and adult human CD45R0- CD4 T cells, J. Clin. Invest. 1994 Oct;94(4):1352-8.
• 1994
  Demeure CE, Wu CY, Shu U, Schneider PV, Heusser C, Yssel H, Delespesse G, In vitro maturation of human neonatal CD4 T lymphocytes. II. Cytokines present at priming modulate the development of lymphokine production, J. Immunol. 1994 May;152(10):4775-82.
• 1994
  Wu CY, Demeure CE, Gately M, Podlaski F, Yssel H, Kiniwa M, Delespesse G, In vitro maturation of human neonatal CD4 T lymphocytes. I. Induction of IL-4-producing cells after long-term culture in the presence of IL-4 plus either IL-2 or IL-12, J. Immunol. 1994 Feb;152(3):1141-53.
• 1993
  Demeure CE, Rihet P, Abel L, Ouattara M, Bourgois A, Dessein AJ, Resistance to Schistosoma mansoni in humans: influence of the IgE/IgG4 balance and IgG2 in immunity to reinfection after chemotherapy, J. Infect. Dis. 1993 Oct;168(4):1000-8.
• 1993
  Wu CY, Demeure C, Kiniwa M, Gately M, Delespesse G, IL-12 induces the production of IFN-gamma by neonatal human CD4 T cells, J. Immunol. 1993 Aug;151(4):1938-49.
• 1993
  de Jesus AM, Almeida RP, Bacellar O, Araujo MI, Demeure C, Bina JC, Dessein AJ, Carvalho EM, Correlation between cell-mediated immunity and degree of infection in subjects living in an endemic area of schistosomiasis, Eur. J. Immunol. 1993 Jan;23(1):152-8.
• 1992
  Rihet P, Demeure CE, Dessein AJ, Bourgois A, Strong serum inhibition of specific IgE correlated to competing IgG4, revealed by a new methodology in subjects from a S. mansoni endemic area, Eur. J. Immunol. 1992 Aug;22(8):2063-70.
• 1992
  Dessein AJ, Couissinier P, Demeure C, Rihet P, Kohlstaedt S, Carneiro-Carvalho D, Ouattara M, Goudot-Crozel V, Dessein H, Bourgois A, Environmental, genetic and immunological factors in human resistance to Schistosoma mansoni, Immunol. Invest. 1992 Aug;21(5):423-53.
• 1991
  Rihet P, Demeure CE, Bourgois A, Prata A, Dessein AJ, Evidence for an association between human resistance to Schistosoma mansoni and high anti-larval IgE levels, Eur. J. Immunol. 1991 Nov;21(11):2679-86.
• 1988
  Dessein AJ, Begley M, Demeure C, Caillol D, Fueri J, dos Reis MG, Andrade ZA, Prata A, Bina JC, Human resistance to Schistosoma mansoni is associated with IgG reactivity to a 37-kDa larval surface antigen, J. Immunol. 1988 Apr;140(8):2727-36.
• 1987
  Anfosso F, Demeure C, Delaage M, Cheballah R, Bellot F, Bourgois A, Conformational differences of human IgE on hydrophobic and hydrophilic solid phases detected by monoclonal antibodies, Mol. Immunol. 1987 Nov;24(11):1129-34.