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© Marie-Christine Prévost, Anne Derbise
Bactéries Yersinia pestis en microscopie electronique à balayage.
Publication : Vaccine

Subcutaneous vaccination with a live attenuated Yersinia pseudotuberculosis plague vaccine

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Vaccine - 18 Jan 2020

Derbise A, Guillas C, Gerke C, Carniel E, Pizarro-Cerdà J, Demeure CE

Link to Pubmed [PMID] – 31964555

Vaccine 2020 Jan;

A single oral inoculation to mice of the live attenuated Yersinia pseudotuberculosis VTnF1 strain producing an F1 pseudocapsule protects against bubonic and pneumonic plague. However oral vaccination can fail in humans exposed to frequent intestinal infections. We evaluated in mice the efficacy of subcutaneous vaccine injection as an alternative way to induce protective immunity, while reducing the dose and avoiding strain release in nature. A single subcutaneous dose of up to 10 CFU induced dose-dependent antibody production. At the dose of 10 CFU, i.e. 10 times less than via the oral route, it caused a modest skin reaction and protected 100% against bubonic and 80% against pneumonic plague, caused by high doses of Yersinia pestis. Bacteria migrating to lymph nodes and spleen, but not feces, were rapidly eliminated. Thus, subcutaneous injection of VTnF1 would represent a good alternative when dissemination in nature and human intestinal responsiveness are limitations.

https://www.ncbi.nlm.nih.gov/pubmed/31964555