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© Research
Publication : International archives of allergy and immunology

OX40-Mediated cosignal enhances the maturation of naive human CD4+ T cells into high IL-4-producing effectors

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in International archives of allergy and immunology - 01 Feb 1999

Delespesse G, Ohshima Y, Yang LP, Demeure C, Sarfati M

Link to Pubmed [PMID] – 10224454

Int. Arch. Allergy Immunol. 1999 Feb-Apr;118(2-4):384-6

Our previous studies have indicated that naive human CD4+ T cells of neonatal or adult origin may be the initial source of IL-4 which is required for their development into Th2 effectors. In addition to minute amounts of IL-4, anti-CD3/B7.1-activated naive cells also release readily detectable levels of IL-13 and IFN-gamma. The production of IL-4 and IL-13 by naive T cells is differentially regulated by TGF-beta and IL-12. Shortly after activation, naive T cells express surface OX40, a TNF-R family member whose ligand (OX40L) is constitutively expressed on a subset of dendritic cells. Engagement of OX40 on activated naive T cells increases their expression of IL-4 and IL-13, suppresses that of IFN-gamma and promotes their development into Th2-like effectors.

http://www.ncbi.nlm.nih.gov/pubmed/10224454