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© Marie-Christine Prévost, Anne Derbise
Bactéries Yersinia pestis en microscopie electronique à balayage.
Publication : Comparative immunology, microbiology and infectious diseases

Efficacy of an oral live vaccine for veterinary use against pseudotuberculosis

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Comparative immunology, microbiology and infectious diseases - 19 Jan 2010

Quintard B, Petit T, Ruvoen N, Carniel E, Demeure CE

Link to Pubmed [PMID] – 20034670

Comp. Immunol. Microbiol. Infect. Dis. 2010 Dec;33(6):e59-65

Pseudotuberculosis, an infection caused by the ubiquitous enteropathogenic bacterium Yersinia pseudotuberculosis, is a recurrent veterinary problem in livestock and zoo animals. The only vaccine currently available in zoos is Pseudovac (a mixture of killed strains of various serotypes), but its efficacy is not well established. We show here that Pseudovac does not protect guinea pigs against a severe Y. pseudotuberculosis infection. We thus evaluated the possibility of using a live attenuated Y. pseudotuberculosis strain (IP32680) as an oral vaccine against animal pseudotuberculosis. We report that IP32680 is avirulent for guinea pigs and induces a strong IgG response against various serotypes of Y. pseudotuberculosis. One and two oral inoculations of IP32680 provided 50% and 83% protection, respectively against a severe infection with a highly pathogenic strain. The avirulent Y. pseudotuberculosis IP32680 is therefore much more protective than Pseudovac and may represent a valuable oral vaccine against pseudotuberculosis in zoo animals.

http://www.ncbi.nlm.nih.gov/pubmed/20034670