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© Laurent Debarbieux
Bactériophages sur la bactérie Escherichia coli 0104:H4 souche 55989.
Publication : Current opinion in virology

The intestinal virome: lessons from animal models.

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Current opinion in virology - 23 Oct 2021

Chaffringeon L, Lamy-Besnier Q, Debarbieux L, De Sordi L,

Link to Pubmed [PMID] – 34700287

Link to DOI – S1879-6257(21)00121-810.1016/j.coviro.2021.09.016

Curr Opin Virol 2021 Oct; 51(): 141-148

Mucosal surfaces in contact with the environment host specific microbiota. The intestinal tract harbours the most abundant and diverse bacterial and viral populations interacting with each other as well as with the host. Viruses of the microbiota are important components of this ecosystem, as shown by viral alterations associated with various pathologies. However, practical and ethical constraints limit functional studies of the virome in humans, making animal models invaluable experimental tools to understand its impact on intestinal physiology. In this review, we present the recent advances in the study of virome in animal models. We focus on the strategies used to characterise viral changes in disease models and approaches to modulate the microbiota using viruses. In reviewing the interplay between viruses, bacteria, and the animal host, we highlight the potential and limitations of these models in elucidating the role of the virome in determining human health and disease.

https://pubmed.ncbi.nlm.nih.gov/34700287