The ECOMORE 2 Project, funded by Agence Française de Dévéloppement, aims to guide economic development initiatives in 5 countries belonging to the Southeast Asia region (Cambodia, Vietnam, Lao PDR, Myanmar and the Philippines), in contributing to measure and minimize the health risks for local population in the context of economic development and climate change throughout a One Health approach (http://ecomore.org).
Workpackage Philippines: An innovative program for the control of vector-borne diseases can reduce the risk of dengue, Chikungunya and Zika in urban and peri-urban areas
In 2016 the dengue vaccine Dengvaxia® (Sanofi Pasteur) was implemented in three regions of the Philippines. Most importantly this vaccination program has very recently been halted due to suspected increased risk of more severe disease following infection by dengue virus in vaccinated individuals previously naïve to any of the four dengue virus serotypes. It is furthermore generally agreed that an integrated approach with a significant role for vector control will be needed and in light of this recent retraction of the only available vaccine, mosquito control remains our only tool to reduce the burden of dengue. One of the alternative tools for vector control is the use of autodissemination. Existing tools for vector control of urban diseases is compromised by coverage, cost, insecticide resistance and human compliance. Fast, flexible and safe methods of insecticide delivery offering dramatically improved impacts on mosquito abundance and disease transmission are needed. This study proposes to implement a novel commercial mosquito control approach and evaluate its epidemiological and entomological efficacy. Auto-dissemination (AD) of an insect growth regulator, pyriproxyfen has proved successful in impacting mosquito densities and offers a novel alternative strategy to larviciding. Recently an immediately employable AD device, the In2Care® Mosquito Trap, has been commercialised and shows promise for being an effective tool for reducing dengue transmission. We will implement the In2Care® Mosquito Trap vs. control in community sites matched for previous dengue (hot and cold spots) and evaluate its epidemiological impact.
Primary objective: Assess the extent to which a novel mosquito control program can reduce the extent of dengue transmission and incidence of infection in children 4-15 years of age.
Secondary objective: Implement and train in the Disease Data Management System in selected sites to assess its capacity to monitor and evaluate interventions under differing current surveillance systems available in the sites.