Search anything and hit enter
  • Teams
  • Members
  • Projects
  • Events
  • Calls
  • Jobs
  • publications
  • Software
  • Tools
  • Network
  • Equipment

A little guide for advanced search:

  • Tip 1. You can use quotes "" to search for an exact expression.
    Example: "cell division"
  • Tip 2. You can use + symbol to restrict results containing all words.
    Example: +cell +stem
  • Tip 3. You can use + and - symbols to force inclusion or exclusion of specific words.
    Example: +cell -stem
e.g. searching for members in projects tagged cancer
Search for
Count
IN
OUT
Content 1
  • member
  • team
  • department
  • center
  • program_project
  • nrc
  • whocc
  • project
  • software
  • tool
  • patent
  • Administrative Staff
  • Assistant Professor
  • Associate Professor
  • Clinical Research Assistant
  • Full Professor
  • Graduate Student
  • Lab assistant
  • Non-permanent Researcher
  • Permanent Researcher
  • Pharmacist
  • PhD Student
  • Physician
  • Post-doc
  • Project Manager
  • Research Associate
  • Research Engineer
  • Retired scientist
  • Technician
  • Undergraduate Student
  • Veterinary
  • Visiting Scientist
  • Deputy Director of Center
  • Deputy Director of Department
  • Deputy Director of National Reference Center
  • Deputy Head of Facility
  • Director of Center
  • Director of Department
  • Director of Institute
  • Director of National Reference Center
  • Group Leader
  • Head of Facility
  • Head of Operations
  • Head of Structure
  • Honorary President of the Departement
  • Labex Coordinator
Content 2
  • member
  • team
  • department
  • center
  • program_project
  • nrc
  • whocc
  • project
  • software
  • tool
  • patent
  • Administrative Staff
  • Assistant Professor
  • Associate Professor
  • Clinical Research Assistant
  • Full Professor
  • Graduate Student
  • Lab assistant
  • Non-permanent Researcher
  • Permanent Researcher
  • Pharmacist
  • PhD Student
  • Physician
  • Post-doc
  • Project Manager
  • Research Associate
  • Research Engineer
  • Retired scientist
  • Technician
  • Undergraduate Student
  • Veterinary
  • Visiting Scientist
  • Deputy Director of Center
  • Deputy Director of Department
  • Deputy Director of National Reference Center
  • Deputy Head of Facility
  • Director of Center
  • Director of Department
  • Director of Institute
  • Director of National Reference Center
  • Group Leader
  • Head of Facility
  • Head of Operations
  • Head of Structure
  • Honorary President of the Departement
  • Labex Coordinator
Search
Go back
Scroll to top
Share
© Research
Project

Upstream stimulating factors USF1 and USF2 in the host response to Helicobacter pylori infection : impact on gastric carcinogenesis

Scientific Fields
Diseases
Organisms
Applications
Technique
Starting Date
08
Sep 2015
Status
Ongoing
Members
4
Structures
2
Instituts
1
Publications
1

About

The usptream stimulating factors USF1 and USF2 are pleïotropic transcription factors belong to the bHLH-Zip family as  the oncogene c-Myc. They act as homo- or heterodimers and interact with DNA consensus E-box sequences in the promoter region of their target genes. USF 1 and USF2 are ubiquitously expressed and regulate the expression of genes involved in the cellular response to stress, cell cycle control, immune response, inflammation and the maintenance of genome stability (Corre and Galibert, 2005).  Several lines of evidence suggest that USF factors may act as tumor suppressors  (Chen et al, 2006). Through DNA hypermethylation, H. pylori  modulates important host cell functions. Our previous work showed a transcriptional inhibition by DNA hypermethylation of USF1 and USF2 in the presence of H. pylori infection (Bussière et al, 2010). We postulate that the deregulation of USF1 and USF2 should impact the oncogenic properties of H. pylori. The aims of this project are to investigate i) the H. pylori-mediated regulatory mechanisms on USF1 and USF2 and their consequences on the promotion of gastric carcinogenesis ii) the H. pylori factors responsible for USF1 and USF2 deregulation. (Collaboration, MD Galibert, University of Rennes, D. Lamarque AP-HP, France).

Fundings