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  • member
  • team
  • department
  • center
  • program_project
  • nrc
  • whocc
  • project
  • software
  • tool
  • patent
  • Administrative Staff
  • Assistant Professor
  • Associate Professor
  • Clinical Research Assistant
  • Clinical Research Nurse
  • Clinician Researcher
  • Department Manager
  • Dual-education Student
  • Full Professor
  • Honorary Professor
  • Lab assistant
  • Master Student
  • Non-permanent Researcher
  • Nursing Staff
  • Permanent Researcher
  • Pharmacist
  • PhD Student
  • Physician
  • Post-doc
  • Prize
  • Project Manager
  • Research Associate
  • Research Engineer
  • Retired scientist
  • Technician
  • Undergraduate Student
  • Veterinary
  • Visiting Scientist
  • Deputy Director of Center
  • Deputy Director of Department
  • Deputy Director of National Reference Center
  • Deputy Head of Facility
  • Director of Center
  • Director of Department
  • Director of Institute
  • Director of National Reference Center
  • Group Leader
  • Head of Facility
  • Head of Operations
  • Head of Structure
  • Honorary President of the Departement
  • Labex Coordinator
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Scientific Fields
Diseases
Organisms
Applications
Technique
Starting Date
01
Jun 2021
Ending Date
01
Jun 2026
Status
Ongoing
Members
6
Structures
3

About

The popCell project aims to characterize the variation in immune response to SARS-CoV-2 of peripheral blood mononuclear cells (PBMCs) from > 200 adult, healthy volunteers of West European, Central African and East Asian origin, (EvoImmunoPop and SeroPrevHK-CoV-19 cohorts). In this project, we have acquired single-cell transcriptional profiles (scRNA-seq) of >1M PBMCs following stimulation by SARS-CoV-2, Influenza A virus (IAV) or mock controls, in order to analyze the differences in immune response to SARS-CoV-2 between human populations worldwide. In addition, all donors were genotyped at >2.5 M sites using the Omni5 Illumina BeadChip, allowing to perform eQTL mapping and to define the role of genetics in these differences. These data will be integrated with chromatin accessibility data (scATAC-seq) and viral serologies (VIRscan) obtained in the basal state to identify regulatory regions that respond to environmental stimuli and contribute to the priming of immune responses to SARS-CoV-2.

Any reanalysis of data published as part of the COVID-19 popCell project are listed below, together with the aim of the reanalysis and name of the person responsible of the data.

List of data reuse:
TBD

Fundings