COVID-19-popCell – Genetic and infectious factors underlying population variability in immune responses to SARS-CoV-2
The popCell project aims to characterize the variation in immune response to SARS-CoV-2 of peripheral blood mononuclear cells (PBMCs) from > 200 adult, healthy volunteers of West European, Central African and East Asian origin, […]
GATTACA: Genetics of Alternative TranscripT Abundance upon Cellular Activation
Context of the project. The human body is constantly exposed to infectious agents. Efficient immune response is therefore fundamental to protect the cells from infection and keep individuals healthy. Yet, substantial variation is observed […]
Human Evolutionary Immunogenomics: population genetic variation in immune responses Recent genome-wide association studies have successfully identified rare and common variants that correlate with complex traits. However, they have provided us with little insight into […]
Genetics of gene expression in immunity to infection
By integrating cutting-edge knowledge and technology in the fields of genomics, population genetics, immunology and bioinformatics, our aim is to establish a thorough understanding of how variable the human immune response is in the […]
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2022Early IFNβ secretion determines variable downstream IL-12p70 responses upon TLR4 activation., Cell Rep 2022 Jun; 39(13): 110989.
2022Integrative genetic and immune cell analysis of plasma proteins in healthy donors identifies novel associations involving primary immune deficiency genes., Genome Med 2022 03; 14(1): 28.
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2020Two common disease-associated TYK2 variants impact exon splicing and TYK2 dosage., PLoS One 2020 ; 15(1): e0225289.
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