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Content 2
  • member
  • team
  • department
  • center
  • program_project
  • nrc
  • whocc
  • project
  • software
  • tool
  • patent
  • Administrative Staff
  • Assistant Professor
  • Associate Professor
  • Clinical Research Assistant
  • Clinical Research Nurse
  • Clinician Researcher
  • Department Manager
  • Dual-education Student
  • Full Professor
  • Honorary Professor
  • Lab assistant
  • Master Student
  • Non-permanent Researcher
  • Nursing Staff
  • Permanent Researcher
  • Pharmacist
  • PhD Student
  • Physician
  • Post-doc
  • Prize
  • Project Manager
  • Research Associate
  • Research Engineer
  • Retired scientist
  • Technician
  • Undergraduate Student
  • Veterinary
  • Visiting Scientist
  • Deputy Director of Center
  • Deputy Director of Department
  • Deputy Director of National Reference Center
  • Deputy Head of Facility
  • Director of Center
  • Director of Department
  • Director of Institute
  • Director of National Reference Center
  • Group Leader
  • Head of Facility
  • Head of Operations
  • Head of Structure
  • Honorary President of the Departement
  • Labex Coordinator
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Scientific Fields
Diseases
Organisms
Applications
Technique
Starting Date
01
Jan 2023
Ending Date
31
Dec 2024
Status
Not started
Members
2
Structures
1
Instituts
1

About

Dissemination of tumor cells and metastasis represent the major cause of death in cancer patients. More than 5% of patients show liver metastases at the time of primary cancer diagnosis, a feature associated with poor prognosis and low 1-year survival rates. An increasing number of immunotherapies aim to target cancer cells by harnessing natural killer (NK) cells, taking advantage of their strong anti-tumor/anti-metastasis potential. NK cells belong to the family of innate lymphoid cells (ILC) and have the capacity to kill target cells directly. Very recently it has been shown that another population of ILCs, called ILC1, also possesses target cell-killing capacities. ILC1, in contrast to NK cells, do not recirculate in the body but reside in tissues and could represent a first line of defense against metastatic seeding. Currently, the understanding of the heterogeneity and function of NK cells and ILC populations that infiltrate metastases (MILCs) is limited, yet, knowledge thereof could be key for the development of optimized treatments. Therefore, the identification of novel cellular and molecular pathways underlying anti-metastatic activities of NK cells and ILC1 to inhibit tumor expansion and dissemination is a pressing unmet need.

In this research program, we aim at assessing the heterogeneity of NK cells and ILC1 in metastases from patients and different mouse models of metastasis to reveal type 1 effector programs that provide protection against metastatic spread that might serve to develop novel treatments.

Fundings