Timeline

Pierre-Jean Corringer

Head of Structure

05 Sep 2024

news

New publication – The Nicotinic Acetylcholine Receptor and its Pentameric Homologs: Toward an Allosteric Mechanism of Signal Transduction at the Atomic Level

24 Jun 2024

publication

Mapping the molecular motions of 5-HT3 serotonin-gated channel by voltage-clamp fluorometry.

12 Feb 2024

publication

The Nicotinic Acetylcholine Receptor and its Pentameric Homologs: Toward an Allosteric Mechanism of Signal Transduction at the Atomic Level.

08 Feb 2024

event

Neuroscience Departmental Seminar: “Slow AMPA receptors.”

01 Feb 2024

publication

Short-chain mono-carboxylates as negative modulators of allosteric transitions in Gloeobacter violaceus ligand-gated ion channel, and impact of a pre-β5 strand (Loop Ω) double mutation on crotonate, not butyrate effect.

25 Sep 2023

publication

An original potentiating mechanism revealed by the cryo-EM structures of the human α7 nicotinic receptor in complex with nanobodies.

25 May 2023

publication

Generation of nanobodies acting as silent and positive allosteric modulators of the α7 nicotinic acetylcholine receptor.

07 Apr 2023

publication

Fumarate as positive modulator of allosteric transitions in the pentameric ligand-gated ion channel GLIC: Requirement of an intact vestibular pocket.

13 Feb 2023

publication

Illumination of a progressive allosteric mechanism mediating the glycine receptor activation.

27 Jan 2023

event

Department of Neuroscience seminar Vladan Lučić (Max Planck Institute of Biochemistry, Germany) – Architecture of synaptic protein assemblies by cryo-electron tomography

22 Dec 2022

publication

Design of crotoxin-based peptides with potentiator activity targeting the ΔF508NBD1 Cystic Fibrosis Transmembrane Conductance Regulator.

18 Nov 2022

publication

Conformational state-dependent regulation of GABAA receptor diffusion and subsynaptic domains.

14 Oct 2022

publication

Lateral fenestrations in the extracellular domain of the glycine receptor contribute to the main chloride permeation pathway.

30 Sep 2021

publication

Mutational analysis to explore long-range allosteric couplings involved in a pentameric channel receptor pre-activation and activation.

01 Feb 2021

publication

Alterations in nicotinic receptor alpha5 subunit gene differentially impact early and later stages of cocaine addiction: a translational study in transgenic rats and patients.

23 Oct 2020

publication

The desensitization pathway of GABAA receptors, one subunit at a time.

14 Nov 2019

event

DPT NEUROSCIENCE – Thesis defence : Mariano GENERA – Structural and functional study of the human phosphatase PTPN3 and its interaction with oncogenic viruses.

08 Oct 2019

project

HBP-CDP6: Modelling for Drug Discovery

08 Oct 2019

project

ANR-Pentacontrol

08 Oct 2019

project

ERC advanced DYNACOTINE

02 Sep 2019

event

PhD defense – Solène Lefebvre – “Applications de la fluorescence pour la caractérisation structurale et dynamique d’intermédiaires conformationnels des récepteurs-canaux pentamériques” – Department of Neuroscience

29 Mar 2019

publication

Large Intracellular Domain-Dependent Effects of Positive Allosteric Modulators on Glycine Receptors

12 Feb 2019

team

UMR3571 – Genes, Synapses and Cognition

24 Jan 2019

event

Neuroscience Seminar Series : Structure-guided design of synthetic connectors for synaptic repair.

12 Dec 2018

publication

Electrostatics, proton sensor, and networks governing the gating transition in GLIC, a proton-gated pentameric ion channel

31 Oct 2018

publication

Conformational transitions of the serotonin 5-HT receptor

04 Sep 2018

publication

Structural titration of receptor ion channel GLIC gating by HS-AFM

15 May 2018

publication

The dual-gate model for pentameric ligand-gated ion channels activation and desensitization.

09 Apr 2018

publication

Crystal structures of a pentameric ion channel gated by alkaline pH show a widely open pore and identify a cavity for modulation

27 Feb 2018

project

Toxins and VHHs as subtype-specific ligands and allosteric modulators of nicotinic acetylcholine receptors (PTR Nicobinder)

27 Feb 2018

project

Discovery of allosteric modulators specifically targeting α5-containing nAChRs. (ANR-Nicofive)

24 Jan 2018

project

MECANICOC

27 Dec 2017

publication

Full mutational mapping of titratable residues helps to identify proton-sensors involved in the control of channel gating in the Gloeobacter violaceus pentameric ligand-gated ion channel

30 Nov 2017

publication

Interaction of Synthetic Human SLURP-1 with the Nicotinic Acetylcholine Receptors

14 Apr 2017

event

Neuroscience – unité Récepteurs-Canaux Lab Seminar

15 Jul 2016

publication

Interaction of three-finger proteins from snake venoms and from mammalian brain with the cys-loop receptors and their models

06 Jun 2016

publication

Phosphorylation state-dependent modulation of spinal glycine receptors alleviates inflammatory pain

27 May 2016

publication

Rattlesnake Phospholipase A2 Increases CFTR-Chloride Channel Current and Corrects ∆F508CFTR Dysfunction: Impact in Cystic Fibrosis

04 May 2016

publication

Emerging Molecular Mechanisms of Signal Transduction in Pentameric Ligand-Gated Ion Channels

05 Feb 2016

publication

Neurotoxic phospholipase A2 from rattlesnake as a new ligand and new regulator of prokaryotic receptor GLIC (proton-gated ion channel from G. violaceus)

14 May 2015

publication

Ethanol Modulation is Quantitatively Determined by the Transmembrane Domain of Human α1 Glycine Receptors

03 Mar 2015

publication

Allosteric and hyperekplexic mutant phenotypes investigated on an α1 glycine receptor transmembrane structure.

21 Sep 2014

team

Signaling and receptors dynamics

23 Dec 2013

publication

Crystal structures of a pentameric ligand-gated ion channel provide a mechanism for activation

01 Oct 2013

publication

Intermediate closed state for glycine receptor function revealed by cysteine cross-linking

04 Jun 2013

publication

Identification of cinnamic acid derivatives as novel antagonists of the prokaryotic proton-gated ion channel GLIC

05 Mar 2013

publication

Structural sensitivity of a prokaryotic pentameric ligand-gated ion channel to its membrane environment

12 Feb 2013

publication

Structural basis for ion permeation mechanism in pentameric ligand-gated ion channels

03 Oct 2012

publication

Pentameric ligand-gated ion channel ELIC is activated by GABA and modulated by benzodiazepines

06 Jun 2012

publication

Structure and pharmacology of pentameric receptor channels: from bacteria to brain

13 May 2012

publication

A locally closed conformation of a bacterial pentameric proton-gated ion channel

23 Dec 2011

publication

[X-ray structures of general anesthetics bound to their molecular targets]

20 Oct 2011

publication

Unravelling the conformational plasticity of the extracellular domain of a prokaryotic nAChR homologue in solution by NMR

05 Jul 2011

publication

Functional prokaryotic-eukaryotic chimera from the pentameric ligand-gated ion channel family

05 Jul 2011

publication

Structural basis for alcohol modulation of a pentameric ligand-gated ion channel

29 Jun 2011

publication

Discrimination of agonists versus antagonists of nicotinic ligands based on docking onto AChBP structures

20 Jan 2011

publication

X-ray structures of general anaesthetics bound to a pentameric ligand-gated ion channel

14 Aug 2010

publication

3D structure and allosteric modulation of the transmembrane domain of pentameric ligand-gated ion channels

22 Mar 2010

publication

One-microsecond molecular dynamics simulation of channel gating in a nicotinic receptor homologue

07 Dec 2009

publication

Atomic structure and dynamics of pentameric ligand-gated ion channels: new insight from bacterial homologues

21 Nov 2009

publication

Anesthetic sensitivity of the Gloeobacter violaceus proton-gated ion channel

13 Nov 2009

publication

Crystal structure of the extracellular domain of a bacterial ligand-gated ion channel

01 Sep 2009

publication

Nicotinic receptors: allosteric transitions and therapeutic targets in the nervous system

05 Nov 2008

publication

X-ray structure of a pentameric ligand-gated ion channel in an apparently open conformation

08 Oct 2008

publication

Regional differential effects of chronic nicotine on brain alpha 4-containing and alpha 6-containing receptors

10 Dec 2006

publication

A prokaryotic proton-gated ion channel from the nicotinic acetylcholine receptor family

31 Oct 2006

publication

Implications of the quaternary twist allosteric model for the physiology and pathology of nicotinic acetylcholine receptors

03 Feb 2006

publication

Nicotine enhances intracellular nicotinic receptor maturation: a novel mechanism of neural plasticity?

19 May 2005

publication

Nicotine upregulates its own receptors through enhanced intracellular maturation

01 Apr 2005

publication

Normal mode analysis suggests a quaternary twist model for the nicotinic receptor gating mechanism

05 Feb 2004

publication

An extracellular protein microdomain controls up-regulation of neuronal nicotinic acetylcholine receptors by nicotine

01 Feb 2004

publication

Distinct subcellular targeting of fluorescent nicotinic alpha 3 beta 4 and serotoninergic 5-HT3A receptors in hippocampal neurons

01 May 2003

publication

An H-bond between two residues from different loops of the acetylcholine binding site contributes to the activation mechanism of nicotinic receptors

01 Dec 2002

publication

The diversity of subunit composition in nAChRs: evolutionary origins, physiologic and pharmacologic consequences

25 Sep 2002

publication

Allosteric transitions of Torpedo acetylcholine receptor in lipids, detergent and amphipols: molecular interactions vs. physical constraints

26 Feb 2002

publication

Experimentally based model of a complex between a snake toxin and the alpha 7 nicotinic receptor

13 Mar 2001

publication

A method for soluble overexpression of the alpha7 nicotinic acetylcholine receptor extracellular domain

20 Feb 2001

publication

Desensitization of neuronal nicotinic acetylcholine receptors conferred by N-terminal segments of the beta 2 subunit

22 Sep 2000

publication

Molecular determinants by which a long chain toxin from snake venom interacts with the neuronal alpha 7-nicotinic acetylcholine receptor

13 Jun 2000

publication

Structural differences in the two agonist binding sites of the Torpedo nicotinic acetylcholine receptor revealed by time-resolved fluorescence spectroscopy

30 Mar 2000

publication

Molecular characterization of the specificity of interactions of various neurotoxins on two distinct nicotinic acetylcholine receptors

01 Jan 2000

publication

Nicotinic receptors at the amino acid level

01 May 1999

publication

Improved secondary structure predictions for a nicotinic receptor subunit: incorporation of solvent accessibility and experimental data into a two-dimensional representation

01 Apr 1999

publication

Mutational analysis of the charge selectivity filter of the alpha7 nicotinic acetylcholine receptor

01 May 1998

publication

Brain nicotinic receptors: structure and regulation, role in learning and reinforcement

01 Apr 1998

publication

Functional determinants by which snake and cone snail toxins block the alpha 7 neuronal nicotinic acetylcholine receptors

01 Feb 1998

publication

Ivermectin: a positive allosteric effector of the alpha7 neuronal nicotinic acetylcholine receptor

15 Jan 1998

publication

Critical elements determining diversity in agonist binding and desensitization of neuronal nicotinic acetylcholine receptors

10 Nov 1997

publication

Paradoxical allosteric effects of competitive inhibitors on neuronal alpha7 nicotinic receptor mutants

01 Nov 1996

publication

Identification of calcium binding sites that regulate potentiation of a neuronal nicotinic acetylcholine receptor

01 Jan 1996

publication

Nicotinic receptors and brain plasticity

19 May 1995

publication

Identification of a new component of the agonist binding site of the nicotinic alpha 7 homooligomeric receptor

01 Feb 1995

publication

CCKA, but not CCKB, agonists suppress the hyperlocomotion induced by endogenous enkephalins, protected from enzymatic degradation by systemic RB 101

01 Jan 1993

publication

CCK-B agonist or antagonist activities of structurally hindered and peptidase-resistant Boc-CCK4 derivatives

01 Nov 1992

publication

[Study of induced effects by selective CCKB agonists cholecystokinin in the nociception and behavior in rodents]

01 Jun 1992

publication

[3H]pBC 264, a suitable probe for studying cholecystokinin-B receptors: binding characteristics in rodent brains and comparison with [3H]SNF 8702

13 Sep 1989

publication

A little guide for advanced search:

New publication – The Nicotinic Acetylcholine Receptor and its Pentameric Homologs: Toward an Allosteric Mechanism of Signal Transduction at the Atomic Level

Mapping the molecular motions of 5-HT3 serotonin-gated channel by voltage-clamp fluorometry.

The Nicotinic Acetylcholine Receptor and its Pentameric Homologs: Toward an Allosteric Mechanism of Signal Transduction at the Atomic Level.

Neuroscience Departmental Seminar: “Slow AMPA receptors.”

Short-chain mono-carboxylates as negative modulators of allosteric transitions in Gloeobacter violaceus ligand-gated ion channel, and impact of a pre-β5 strand (Loop Ω) double mutation on crotonate, not butyrate effect.

An original potentiating mechanism revealed by the cryo-EM structures of the human α7 nicotinic receptor in complex with nanobodies.

Generation of nanobodies acting as silent and positive allosteric modulators of the α7 nicotinic acetylcholine receptor.

Fumarate as positive modulator of allosteric transitions in the pentameric ligand-gated ion channel GLIC: Requirement of an intact vestibular pocket.

Illumination of a progressive allosteric mechanism mediating the glycine receptor activation.

Department of Neuroscience seminar Vladan Lučić (Max Planck Institute of Biochemistry, Germany) – Architecture of synaptic protein assemblies by cryo-electron tomography

Design of crotoxin-based peptides with potentiator activity targeting the ΔF508NBD1 Cystic Fibrosis Transmembrane Conductance Regulator.

Conformational state-dependent regulation of GABAA receptor diffusion and subsynaptic domains.

Lateral fenestrations in the extracellular domain of the glycine receptor contribute to the main chloride permeation pathway.

Mutational analysis to explore long-range allosteric couplings involved in a pentameric channel receptor pre-activation and activation.

Alterations in nicotinic receptor alpha5 subunit gene differentially impact early and later stages of cocaine addiction: a translational study in transgenic rats and patients.

The desensitization pathway of GABAA receptors, one subunit at a time.

DPT NEUROSCIENCE – Thesis defence : Mariano GENERA – Structural and functional study of the human phosphatase PTPN3 and its interaction with oncogenic viruses.

HBP-CDP6: Modelling for Drug Discovery

ANR-Pentacontrol

ERC advanced DYNACOTINE

PhD defense – Solène Lefebvre – “Applications de la fluorescence pour la caractérisation structurale et dynamique d’intermédiaires conformationnels des récepteurs-canaux pentamériques” – Department of Neuroscience

Large Intracellular Domain-Dependent Effects of Positive Allosteric Modulators on Glycine Receptors

UMR3571 – Genes, Synapses and Cognition

Neuroscience Seminar Series : Structure-guided design of synthetic connectors for synaptic repair.

Electrostatics, proton sensor, and networks governing the gating transition in GLIC, a proton-gated pentameric ion channel

Conformational transitions of the serotonin 5-HT receptor

Structural titration of receptor ion channel GLIC gating by HS-AFM

The dual-gate model for pentameric ligand-gated ion channels activation and desensitization.

Crystal structures of a pentameric ion channel gated by alkaline pH show a widely open pore and identify a cavity for modulation

Toxins and VHHs as subtype-specific ligands and allosteric modulators of nicotinic acetylcholine receptors (PTR Nicobinder)

Discovery of allosteric modulators specifically targeting α5-containing nAChRs. (ANR-Nicofive)

MECANICOC

Full mutational mapping of titratable residues helps to identify proton-sensors involved in the control of channel gating in the Gloeobacter violaceus pentameric ligand-gated ion channel

Interaction of Synthetic Human SLURP-1 with the Nicotinic Acetylcholine Receptors

Neuroscience – unité Récepteurs-Canaux Lab Seminar

Interaction of three-finger proteins from snake venoms and from mammalian brain with the cys-loop receptors and their models

Phosphorylation state-dependent modulation of spinal glycine receptors alleviates inflammatory pain

Rattlesnake Phospholipase A2 Increases CFTR-Chloride Channel Current and Corrects ∆F508CFTR Dysfunction: Impact in Cystic Fibrosis

Emerging Molecular Mechanisms of Signal Transduction in Pentameric Ligand-Gated Ion Channels

Neurotoxic phospholipase A2 from rattlesnake as a new ligand and new regulator of prokaryotic receptor GLIC (proton-gated ion channel from G. violaceus)

Ethanol Modulation is Quantitatively Determined by the Transmembrane Domain of Human α1 Glycine Receptors

Allosteric and hyperekplexic mutant phenotypes investigated on an α1 glycine receptor transmembrane structure.

Signaling and receptors dynamics

Crystal structures of a pentameric ligand-gated ion channel provide a mechanism for activation

Intermediate closed state for glycine receptor function revealed by cysteine cross-linking

Identification of cinnamic acid derivatives as novel antagonists of the prokaryotic proton-gated ion channel GLIC

Structural sensitivity of a prokaryotic pentameric ligand-gated ion channel to its membrane environment

Structural basis for ion permeation mechanism in pentameric ligand-gated ion channels

Pentameric ligand-gated ion channel ELIC is activated by GABA and modulated by benzodiazepines

Structure and pharmacology of pentameric receptor channels: from bacteria to brain

A locally closed conformation of a bacterial pentameric proton-gated ion channel

[X-ray structures of general anesthetics bound to their molecular targets]

Unravelling the conformational plasticity of the extracellular domain of a prokaryotic nAChR homologue in solution by NMR

Functional prokaryotic-eukaryotic chimera from the pentameric ligand-gated ion channel family

Structural basis for alcohol modulation of a pentameric ligand-gated ion channel

Discrimination of agonists versus antagonists of nicotinic ligands based on docking onto AChBP structures

X-ray structures of general anaesthetics bound to a pentameric ligand-gated ion channel

3D structure and allosteric modulation of the transmembrane domain of pentameric ligand-gated ion channels

One-microsecond molecular dynamics simulation of channel gating in a nicotinic receptor homologue

Atomic structure and dynamics of pentameric ligand-gated ion channels: new insight from bacterial homologues

Anesthetic sensitivity of the Gloeobacter violaceus proton-gated ion channel

Crystal structure of the extracellular domain of a bacterial ligand-gated ion channel

Nicotinic receptors: allosteric transitions and therapeutic targets in the nervous system

X-ray structure of a pentameric ligand-gated ion channel in an apparently open conformation

Regional differential effects of chronic nicotine on brain alpha 4-containing and alpha 6-containing receptors

A prokaryotic proton-gated ion channel from the nicotinic acetylcholine receptor family

Implications of the quaternary twist allosteric model for the physiology and pathology of nicotinic acetylcholine receptors

Nicotine enhances intracellular nicotinic receptor maturation: a novel mechanism of neural plasticity?

Nicotine upregulates its own receptors through enhanced intracellular maturation

Normal mode analysis suggests a quaternary twist model for the nicotinic receptor gating mechanism

An extracellular protein microdomain controls up-regulation of neuronal nicotinic acetylcholine receptors by nicotine

Distinct subcellular targeting of fluorescent nicotinic alpha 3 beta 4 and serotoninergic 5-HT3A receptors in hippocampal neurons

An H-bond between two residues from different loops of the acetylcholine binding site contributes to the activation mechanism of nicotinic receptors

The diversity of subunit composition in nAChRs: evolutionary origins, physiologic and pharmacologic consequences

Allosteric transitions of Torpedo acetylcholine receptor in lipids, detergent and amphipols: molecular interactions vs. physical constraints

Experimentally based model of a complex between a snake toxin and the alpha 7 nicotinic receptor

A method for soluble overexpression of the alpha7 nicotinic acetylcholine receptor extracellular domain

Desensitization of neuronal nicotinic acetylcholine receptors conferred by N-terminal segments of the beta 2 subunit

Molecular determinants by which a long chain toxin from snake venom interacts with the neuronal alpha 7-nicotinic acetylcholine receptor