-
2024Mapping the molecular motions of 5-HT3 serotonin-gated channel by voltage-clamp fluorometry., Elife 2024 Jun; 12(): .
-
2024The Nicotinic Acetylcholine Receptor and its Pentameric Homologs: Toward an Allosteric Mechanism of Signal Transduction at the Atomic Level., Annu Rev Biochem 2024 Feb; (): .
-
2024Short-chain mono-carboxylates as negative modulators of allosteric transitions in Gloeobacter violaceus ligand-gated ion channel, and impact of a pre-β5 strand (Loop Ω) double mutation on crotonate, not butyrate effect., Physiol Rep 2024 Feb; 12(3): e15916.
-
2023An original potentiating mechanism revealed by the cryo-EM structures of the human α7 nicotinic receptor in complex with nanobodies., Nat Commun 2023 Sep; 14(1): 5964.
-
2023Generation of nanobodies acting as silent and positive allosteric modulators of the α7 nicotinic acetylcholine receptor., Cell Mol Life Sci 2023 May; 80(6): 164.
-
2023Fumarate as positive modulator of allosteric transitions in the pentameric ligand-gated ion channel GLIC: Requirement of an intact vestibular pocket., J Physiol 2023 Apr; (): .
-
2023Illumination of a progressive allosteric mechanism mediating the glycine receptor activation., Nat Commun 2023 Feb; 14(1): 795.
-
2022Design of crotoxin-based peptides with potentiator activity targeting the ΔF508NBD1 Cystic Fibrosis Transmembrane Conductance Regulator., J Mol Biol 2022 Dec; (): 167929.
-
2022Conformational state-dependent regulation of GABAA receptor diffusion and subsynaptic domains., iScience 2022 Nov; 25(11): 105467.
-
2022Lateral fenestrations in the extracellular domain of the glycine receptor contribute to the main chloride permeation pathway., Sci Adv 2022 Oct; 8(41): eadc9340.
-
2021Mutational analysis to explore long-range allosteric couplings involved in a pentameric channel receptor pre-activation and activation., Elife 2021 Sep; 10(): .
-
2021Alterations in nicotinic receptor alpha5 subunit gene differentially impact early and later stages of cocaine addiction: a translational study in transgenic rats and patients., Prog Neurobiol 2021 02; 197(): 101898.
-
2020The desensitization pathway of GABAA receptors, one subunit at a time., Nat Commun 2020 10; 11(1): 5369.
-
2019Large Intracellular Domain-Dependent Effects of Positive Allosteric Modulators on Glycine Receptors, ACS Chem Neurosci 2019 May;10(5):2551-2559.
-
2018Electrostatics, proton sensor, and networks governing the gating transition in GLIC, a proton-gated pentameric ion channel, Proc. Natl. Acad. Sci. U.S.A. 2018 12;115(52):E12172-E12181.
-
2018Conformational transitions of the serotonin 5-HT receptor, Nature 2018 11;563(7730):275-279.
-
2018Structural titration of receptor ion channel GLIC gating by HS-AFM, Proc. Natl. Acad. Sci. U.S.A. 2018 10;115(41):10333-10338.
-
2018The dual-gate model for pentameric ligand-gated ion channels activation and desensitization., J Physiol 2018 05; 596(10): 1873-1902.
-
2018Crystal structures of a pentameric ion channel gated by alkaline pH show a widely open pore and identify a cavity for modulation, Proc. Natl. Acad. Sci. U.S.A. 2018 04;115(17):E3959-E3968.
-
2017Full mutational mapping of titratable residues helps to identify proton-sensors involved in the control of channel gating in the Gloeobacter violaceus pentameric ligand-gated ion channel, PLoS Biol. 2017 12;15(12):e2004470.
-
2017Interaction of Synthetic Human SLURP-1 with the Nicotinic Acetylcholine Receptors, Sci Rep 2017 Nov;7(1):16606.
-
2016Interaction of three-finger proteins from snake venoms and from mammalian brain with the cys-loop receptors and their models, Dokl. Biochem. Biophys. 2016 May;468(1):193-6.
-
2016Phosphorylation state-dependent modulation of spinal glycine receptors alleviates inflammatory pain, J. Clin. Invest. 2016 Jul;126(7):2547-60.
-
2016Rattlesnake Phospholipase A2 Increases CFTR-Chloride Channel Current and Corrects ∆F508CFTR Dysfunction: Impact in Cystic Fibrosis, J. Mol. Biol. 2016 Jul;428(14):2898-915.
-
2016Emerging Molecular Mechanisms of Signal Transduction in Pentameric Ligand-Gated Ion Channels, Neuron 2016 05;90(3):452-70.
-
2016Neurotoxic phospholipase A2 from rattlesnake as a new ligand and new regulator of prokaryotic receptor GLIC (proton-gated ion channel from G. violaceus), Toxicon 2016 Jun;116:63-71.
-
2015Ethanol Modulation is Quantitatively Determined by the Transmembrane Domain of Human α1 Glycine Receptors, Alcohol. Clin. Exp. Res. 2015 Jun;39(6):962-8.
-
2015Allosteric and hyperekplexic mutant phenotypes investigated on an α1 glycine receptor transmembrane structure., Proc Natl Acad Sci U S A 2015 Mar; 112(9): 2865-70.
-
2013Crystal structures of a pentameric ligand-gated ion channel provide a mechanism for activation, Proc. Natl. Acad. Sci. U.S.A. 2014 Jan;111(3):966-71.
-
2013Intermediate closed state for glycine receptor function revealed by cysteine cross-linking, Proc. Natl. Acad. Sci. U.S.A. 2013 Oct;110(42):17113-8.
-
2013Identification of cinnamic acid derivatives as novel antagonists of the prokaryotic proton-gated ion channel GLIC, J. Med. Chem. 2013 Jun;56(11):4619-30.
-
2013Structural sensitivity of a prokaryotic pentameric ligand-gated ion channel to its membrane environment, J. Biol. Chem. 2013 Apr;288(16):11294-303.
-
2013Structural basis for ion permeation mechanism in pentameric ligand-gated ion channels, EMBO J. 2013 Mar;32(5):728-41.
-
2012Pentameric ligand-gated ion channel ELIC is activated by GABA and modulated by benzodiazepines, Proc. Natl. Acad. Sci. U.S.A. 2012 Oct;109(44):E3028-34.
-
2012Structure and pharmacology of pentameric receptor channels: from bacteria to brain, Structure 2012 Jun;20(6):941-56.
-
2012A locally closed conformation of a bacterial pentameric proton-gated ion channel, Nat. Struct. Mol. Biol. 2012 May;19(6):642-9.
-
2011[X-ray structures of general anesthetics bound to their molecular targets], Med Sci (Paris) 2011 Dec;27(12):1056-7.
-
2011Unravelling the conformational plasticity of the extracellular domain of a prokaryotic nAChR homologue in solution by NMR, Biochemistry 2011 Nov;50(45):9681-3.
-
2011Functional prokaryotic-eukaryotic chimera from the pentameric ligand-gated ion channel family, Proc. Natl. Acad. Sci. U.S.A. 2011 Jul;108(29):12143-8.
-
2011Structural basis for alcohol modulation of a pentameric ligand-gated ion channel, Proc. Natl. Acad. Sci. U.S.A. 2011 Jul;108(29):12149-54.
-
2011Discrimination of agonists versus antagonists of nicotinic ligands based on docking onto AChBP structures, J. Mol. Graph. Model. 2011 Sep;30:100-9.
-
2011X-ray structures of general anaesthetics bound to a pentameric ligand-gated ion channel, Nature 2011 Jan;469(7330):428-31.
-
20103D structure and allosteric modulation of the transmembrane domain of pentameric ligand-gated ion channels, Neuropharmacology 2011 Jan;60(1):116-25.
-
2010One-microsecond molecular dynamics simulation of channel gating in a nicotinic receptor homologue, Proc. Natl. Acad. Sci. U.S.A. 2010 Apr;107(14):6275-80.
-
2009Atomic structure and dynamics of pentameric ligand-gated ion channels: new insight from bacterial homologues, J. Physiol. (Lond.) 2010 Feb;588(Pt 4):565-72.
-
2009Anesthetic sensitivity of the Gloeobacter violaceus proton-gated ion channel, Anesth. Analg. 2010 Jan;110(1):59-63.
-
2009Crystal structure of the extracellular domain of a bacterial ligand-gated ion channel, J. Mol. Biol. 2010 Feb;395(5):1114-27.
-
2009Nicotinic receptors: allosteric transitions and therapeutic targets in the nervous system, Nat Rev Drug Discov 2009 Sep;8(9):733-50.
-
2008X-ray structure of a pentameric ligand-gated ion channel in an apparently open conformation, Nature 2009 Jan;457(7225):111-4.
-
2008Regional differential effects of chronic nicotine on brain alpha 4-containing and alpha 6-containing receptors, Neuroreport 2008 Oct;19(15):1545-50.
-
2006A prokaryotic proton-gated ion channel from the nicotinic acetylcholine receptor family, Nature 2007 Jan;445(7123):116-9.
-
2006Implications of the quaternary twist allosteric model for the physiology and pathology of nicotinic acetylcholine receptors, Proc. Natl. Acad. Sci. U.S.A. 2006 Nov;103(45):16965-70.
-
2006Nicotine enhances intracellular nicotinic receptor maturation: a novel mechanism of neural plasticity?, J. Physiol. Paris 2006 Mar-May;99(2-3):162-71.
-
2005Nicotine upregulates its own receptors through enhanced intracellular maturation, Neuron 2005 May;46(4):595-607.
-
2005Normal mode analysis suggests a quaternary twist model for the nicotinic receptor gating mechanism, Biophys. J. 2005 Jun;88(6):3954-65.
-
2004An extracellular protein microdomain controls up-regulation of neuronal nicotinic acetylcholine receptors by nicotine, J. Biol. Chem. 2004 Apr;279(18):18767-75.
-
2004Distinct subcellular targeting of fluorescent nicotinic alpha 3 beta 4 and serotoninergic 5-HT3A receptors in hippocampal neurons, Eur. J. Neurosci. 2004 Feb;19(4):855-62.
-
2003An H-bond between two residues from different loops of the acetylcholine binding site contributes to the activation mechanism of nicotinic receptors, EMBO J. 2003 May;22(9):1990-2003.
-
2002The diversity of subunit composition in nAChRs: evolutionary origins, physiologic and pharmacologic consequences, J. Neurobiol. 2002 Dec;53(4):447-56.
-
2002Allosteric transitions of Torpedo acetylcholine receptor in lipids, detergent and amphipols: molecular interactions vs. physical constraints, FEBS Lett. 2002 Sep;528(1-3):251-6.
-
2002Experimentally based model of a complex between a snake toxin and the alpha 7 nicotinic receptor, Proc. Natl. Acad. Sci. U.S.A. 2002 Mar;99(5):3216-21.
-
2001A method for soluble overexpression of the alpha7 nicotinic acetylcholine receptor extracellular domain, Proc. Natl. Acad. Sci. U.S.A. 2001 Mar;98(6):3567-70.
-
2001Desensitization of neuronal nicotinic acetylcholine receptors conferred by N-terminal segments of the beta 2 subunit, Biochemistry 2001 Feb;40(7):2066-74.
-
2000Molecular determinants by which a long chain toxin from snake venom interacts with the neuronal alpha 7-nicotinic acetylcholine receptor, J. Biol. Chem. 2000 Sep;275(38):29594-601.
-
2000Structural differences in the two agonist binding sites of the Torpedo nicotinic acetylcholine receptor revealed by time-resolved fluorescence spectroscopy, Biochemistry 2000 Jun;39(23):6979-90.
-
2000Molecular characterization of the specificity of interactions of various neurotoxins on two distinct nicotinic acetylcholine receptors, Eur. J. Pharmacol. 2000 Mar;393(1-3):197-204.
-
2000Nicotinic receptors at the amino acid level, Annu. Rev. Pharmacol. Toxicol. 2000;40:431-58.
-
1999Improved secondary structure predictions for a nicotinic receptor subunit: incorporation of solvent accessibility and experimental data into a two-dimensional representation, Biophys. J. 1999 May;76(5):2329-45.
-
1999Mutational analysis of the charge selectivity filter of the alpha7 nicotinic acetylcholine receptor, Neuron 1999 Apr;22(4):831-43.
-
1998Brain nicotinic receptors: structure and regulation, role in learning and reinforcement, Brain Res. Brain Res. Rev. 1998 May;26(2-3):198-216.
-
1998Functional determinants by which snake and cone snail toxins block the alpha 7 neuronal nicotinic acetylcholine receptors, J. Physiol. Paris 1998 Apr;92(2):107-11.
-
1998Ivermectin: a positive allosteric effector of the alpha7 neuronal nicotinic acetylcholine receptor, Mol. Pharmacol. 1998 Feb;53(2):283-94.
-
1998Critical elements determining diversity in agonist binding and desensitization of neuronal nicotinic acetylcholine receptors, J. Neurosci. 1998 Jan;18(2):648-57.
-
1997Paradoxical allosteric effects of competitive inhibitors on neuronal alpha7 nicotinic receptor mutants, Neuroreport 1997 Nov;8(16):3591-6.
-
1996Identification of calcium binding sites that regulate potentiation of a neuronal nicotinic acetylcholine receptor, EMBO J. 1996 Nov;15(21):5824-32.
-
1996Nicotinic receptors and brain plasticity, Cold Spring Harb. Symp. Quant. Biol. 1996;61:343-62.
-
1995Identification of a new component of the agonist binding site of the nicotinic alpha 7 homooligomeric receptor, J. Biol. Chem. 1995 May;270(20):11749-52.
-
1995CCKA, but not CCKB, agonists suppress the hyperlocomotion induced by endogenous enkephalins, protected from enzymatic degradation by systemic RB 101, Pharmacol. Biochem. Behav. 1995 Feb;50(2):133-9.
-
1993CCK-B agonist or antagonist activities of structurally hindered and peptidase-resistant Boc-CCK4 derivatives, J. Med. Chem. 1993 Jan;36(1):166-72.
-
1992[Study of induced effects by selective CCKB agonists cholecystokinin in the nociception and behavior in rodents], Therapie 1992 Nov;47(6):531-9.
-
1992[3H]pBC 264, a suitable probe for studying cholecystokinin-B receptors: binding characteristics in rodent brains and comparison with [3H]SNF 8702, Mol. Pharmacol. 1992 Jun;41(6):1089-95.
-
1989[3H]pBC 264, first highly potent and very selective radioligand for CCK-B receptors, Eur. J. Pharmacol. 1989 Sep;168(2):269-70.