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Projets
Anciennes Équipes
CV
(EN) Current Position
Research Director DR1 at the CNRS
Co-director of the CNRS Unit “Genes, Synapses and Cognition”
Co-director of the Neuroscience department of the Institut Pasteur
Education / Cursus
1988 Engineer in Chemistry (ESCIL, Lyon).
1992 Ph.D. Pharmacochemistry (Paris V University).
1992-1993 Post-doctoral fellow (Welcome trust) at Brighton University (U.K.).
1993-2006 Research Scientist at the CNRS, Receptor and Cognition unit (J.P. Changeux), Institut Pasteur.
2006-2012 Research Director at the CNRS. Head of a G5 research group, Institut Pasteur.
Awards
2009: Pasteur Vallery-Radot award
2013: Andrée et René Duquesnes award
2014: Elected member of Academia Europa
2015: Grand Prix Emile Jungfleisch from the French academy of sciences
2018: Silver medal of the CNRS
2018: Awarded and ERC advanced grant
Publications
Télécharger-
2023Generation of nanobodies acting as silent and positive allosteric modulators of the α7 nicotinic acetylcholine receptor., Cell Mol Life Sci 2023 May; 80(6): 164.
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2023Fumarate as positive modulator of allosteric transitions in the pentameric ligand-gated ion channel GLIC: Requirement of an intact vestibular pocket., J Physiol 2023 Apr; (): .
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2023Illumination of a progressive allosteric mechanism mediating the glycine receptor activation., Nat Commun 2023 Feb; 14(1): 795.
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2022Design of crotoxin-based peptides with potentiator activity targeting the ΔF508NBD1 Cystic Fibrosis Transmembrane Conductance Regulator., J Mol Biol 2022 Dec; (): 167929.
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2022Conformational state-dependent regulation of GABAA receptor diffusion and subsynaptic domains., iScience 2022 Nov; 25(11): 105467.
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2022Lateral fenestrations in the extracellular domain of the glycine receptor contribute to the main chloride permeation pathway., Sci Adv 2022 Oct; 8(41): eadc9340.
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2021Mutational analysis to explore long-range allosteric couplings involved in a pentameric channel receptor pre-activation and activation., Elife 2021 Sep; 10(): .
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2021Alterations in nicotinic receptor alpha5 subunit gene differentially impact early and later stages of cocaine addiction: a translational study in transgenic rats and patients., Prog Neurobiol 2021 02; 197(): 101898.
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2020The desensitization pathway of GABAA receptors, one subunit at a time., Nat Commun 2020 10; 11(1): 5369.
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2019Large Intracellular Domain-Dependent Effects of Positive Allosteric Modulators on Glycine Receptors, ACS Chem Neurosci 2019 May;10(5):2551-2559.
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