We study the progressive emergence and functional traits of the innate immune system in vertebrate development, taking advantage of the optical transparency of the zebrafish embryo and larva to address questions that are difficult to approach in mammals. Thus we have explored the successive developmental waves of hematopoiesis, from the emergence of hematopoietic stem/progenitor cells (HSPCs) to the deployment of resident leukocytes in the tissues. Then among these leukocytes, we investigate the respective behaviour and roles of the professional phagocytes, macrophages and neutrophils, in the developing organism.
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Directeur de recherche CNRS
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2019Live Tracking of Inter-organ Communication by Endogenous Exosomes In Vivo, Dev. Cell 2019 Feb;48(4):573-589.e4.
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2018Anisotropic organization of circumferential actomyosin characterizes hematopoietic stem cells emergence in the zebrafish, Elife 2018 08;7.
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2018A Model of Superinfection of Virus-Infected Zebrafish Larvae: Increased Susceptibility to Bacteria Associated With Neutrophil Death, Front Immunol 2018;9:1084.
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2017Trim33 / Tif1-γ is essential for macrophage and neutrophil mobilisation to developmental or inflammatory cues, J. Cell. Sci. 2017 Jul;.
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2017Imaging of viral neuroinvasion in the zebrafish reveals that Sindbis and chikungunya viruses favour different entry routes, Dis Model Mech 2017 07;10(7):847-857.
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2016Mutations in CDC14A, Encoding a Protein Phosphatase Involved in Hair Cell Ciliogenesis, Cause Autosomal-Recessive Severe to Profound Deafness, Am. J. Hum. Genet. 2016 06;98(6):1266-1270.
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2015NACA deficiency reveals the crucial role of somite-derived stromal cells in haematopoietic niche formation, Nat Commun 2015;6:8375.
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2014Contrasted innate responses to two viruses in zebrafish: insights into the ancestral repertoire of vertebrate IFN-stimulated genes, J. Immunol. 2014 May;192(9):4328-41.
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2013Zebrafish midbrain slow-amplifying progenitors exhibit high levels of transcripts for nucleotide and ribosome biogenesis, Development 2013 Dec;140(24):4860-9.
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2013Pivotal role of Pten in the balance between proliferation and differentiation of hematopoietic stem cells in zebrafish, Blood 2014 Jan;123(2):184-90.
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