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About

We study the progressive emergence and functional traits of the innate immune system in vertebrate development, taking advantage of the optical transparency of the zebrafish embryo and larva to address questions that are difficult to approach in mammals. Thus we have explored the successive developmental waves of hematopoiesis, from the emergence of hematopoietic stem/progenitor cells (HSPCs) to the deployment of resident leukocytes in the tissues. Then among these leukocytes, we investigate the respective behaviour and roles of the professional phagocytes, macrophages and neutrophils, in the developing organism.

Projects

project
Ongoing
10 Members

Developmental hematopoiesis, from stem cells emergence to tissue resident leukocytes

Philippe Herbomel (PI)

Emi Murayama, Anne Schmidt, Mylène Lancino, Charnese Bowes, Anne-Lou Touret, Sara Majello, Catherine Vivier, Mireille Carrère, Doris Lou Demy, Milka Sarris, Ramil Noche We found that as in mammals, the first leukocytes to arise […]
project
Ongoing
8 Members

Behavior of macrophages and neutrophils in vivo

Philippe Herbomel (PI)

Emma Colucci-Guyon, Jean-Pierre Levraud, Laurent Boucontet, Milka Sarris, Maxence Fretaud The early control of potentially invading microbes by our immune system primarily depends on its main professional phagocytes – macrophages and neutrophils. While the different […]

CV

Directeur de recherche CNRS

Publications

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