We study the progressive emergence and functional traits of the innate immune system in vertebrate development, taking advantage of the optical transparency of the zebrafish embryo and larva to address questions that are difficult to approach in mammals. Thus we have explored the successive developmental waves of hematopoiesis, from the emergence of hematopoietic stem/progenitor cells (HSPCs) to the deployment of resident leukocytes in the tissues. Then among these leukocytes, we investigate the respective behaviour and roles of the professional phagocytes, macrophages and neutrophils, in the developing organism.
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2020The cationic amino acid exporter Slc7a7 is induced and vital in tissue macrophages with sustained efferocytic activity., J Cell Sci 2020 Oct 22; 133(20):jcs249037.
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2019Coronin 1A depletion restores the nuclear stability and viability of Aip1/Wdr1-deficient neutrophils, J. Cell Biol. 2019 Aug;218(10):3258-71.
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2019Resident Macrophage Lookalikes of Unexpected Origin, Dev. Cell 2019 May;49(4):501-502.
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2019Ultraspecific live imaging of the dynamics of zebrafish neutrophil granules by a histopermeable fluorogenic benzochalcone probe, Chem Sci 2019 Mar;10(12):3654-3670.
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2019Live Tracking of Inter-organ Communication by Endogenous Exosomes In Vivo, Dev. Cell 2019 Feb;48(4):573-589.e4.
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2018Anisotropic organization of circumferential actomyosin characterizes hematopoietic stem cells emergence in the zebrafish., Elife 2018 08; 7(): .
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2018A Model of Superinfection of Virus-Infected Zebrafish Larvae: Increased Susceptibility to Bacteria Associated With Neutrophil Death, Front Immunol 2018;9:1084.
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2017Trim33 / Tif1-γ is essential for macrophage and neutrophil mobilisation to developmental or inflammatory cues, J. Cell. Sci. 2017 Jul;130(17):2797-807.
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2017Imaging of viral neuroinvasion in the zebrafish reveals that Sindbis and chikungunya viruses favour different entry routes., Dis Model Mech 2017 07; 10(7): 847-857.
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2016Mutations in CDC14A, Encoding a Protein Phosphatase Involved in Hair Cell Ciliogenesis, Cause Autosomal-Recessive Severe to Profound Deafness, Am. J. Hum. Genet. 2016 06;98(6):1266-1270.
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