Timeline

Philippe Herbomel

Head of Structure

01 Mar 2023

publication

Alcam-a and Pdgfr-α are essential for the development of sclerotome-derived stromal cells that support hematopoiesis.

01 Oct 2022

publication

A dual involvement of Protocadherin 18a in stromal cell development guides the formation of a functional hematopoietic niche.

02 Sep 2022

publication

Trim33 conditions the lifespan of primitive macrophages and onset of definitive macrophage production.

24 Sep 2020

publication

The cationic amino acid exporter Slc7a7 is induced and vital in tissue macrophages with sustained efferocytic activity.

30 Aug 2019

publication

Coronin 1A depletion restores the nuclear stability and viability of Aip1/Wdr1-deficient neutrophils

20 May 2019

publication

Resident Macrophage Lookalikes of Unexpected Origin

14 Feb 2019

publication

Ultraspecific live imaging of the dynamics of zebrafish neutrophil granules by a histopermeable fluorogenic benzochalcone probe

07 Feb 2019

publication

Live Tracking of Inter-organ Communication by Endogenous Exosomes In Vivo

22 Aug 2018

publication

Anisotropic organization of circumferential actomyosin characterizes hematopoietic stem cells emergence in the zebrafish.

24 May 2018

publication

A Model of Superinfection of Virus-Infected Zebrafish Larvae: Increased Susceptibility to Bacteria Associated With Neutrophil Death

27 Feb 2018

event

Department seminar by Professor David Traver, University of California San Diego: “Developmental regulation of hematopoietic stem cells”

19 Jul 2017

publication

Trim33 / Tif1-γ is essential for macrophage and neutrophil mobilisation to developmental or inflammatory cues

01 Jul 2017

publication

Imaging of viral neuroinvasion in the zebrafish reveals that Sindbis and chikungunya viruses favour different entry routes.

07 Oct 2016

news

SEMINAR ” Cellular and developmental mechanisms controlling germ cell migration in zebrafish “

04 Oct 2016

news

SEMINAR “Decoding blood vessels homeostasis : ros signaling, hemodynamics and more”

23 Sep 2016

news

SEMINAR ” Life and Near Death Experiences at the Cellular Level “

02 Jun 2016

publication

Mutations in CDC14A, Encoding a Protein Phosphatase Involved in Hair Cell Ciliogenesis, Cause Autosomal-Recessive Severe to Profound Deafness

01 Oct 2015

news

SEMINAR “Mechanisms of macrophage tissue infiltration”

28 Sep 2015

publication

NACA deficiency reveals the crucial role of somite-derived stromal cells in haematopoietic niche formation

17 Jul 2015

tool

Zebrafish facility

17 Jul 2015

project

Developmental hematopoiesis, from stem cells emergence to tissue resident leukocytes

08 Jun 2015

project

Behaviour of macrophages and neutrophils in vivo

28 Mar 2014

publication

Contrasted innate responses to two viruses in zebrafish: insights into the ancestral repertoire of vertebrate IFN-stimulated genes.

06 Nov 2013

publication

Zebrafish midbrain slow-amplifying progenitors exhibit high levels of transcripts for nucleotide and ribosome biogenesis

11 Oct 2013

publication

Pivotal role of Pten in the balance between proliferation and differentiation of hematopoietic stem cells in zebrafish

05 Sep 2013

publication

The zebrafish as a new model for the in vivo study of Shigella flexneri interaction with phagocytes and bacterial autophagy

05 Sep 2013

publication

Real-time whole-body visualization of Chikungunya Virus infection and host interferon response in zebrafish.

08 Mar 2013

publication

Localized bacterial infection induces systemic activation of neutrophils through Cxcr2 signaling in zebrafish

03 Feb 2013

publication

Generating parabiotic zebrafish embryos for cell migration and homing studies

01 Jan 2013

publication

Bcl-wav and the mitochondrial calcium uniporter drive gastrula morphogenesis in zebrafish

06 Dec 2012

publication

Inflammatory chemokines direct and restrict leukocyte migration within live tissues as glycan-bound gradients

26 Jul 2012

publication

A new zebrafish model of oro-intestinal pathogen colonization reveals a key role for adhesion in protection by probiotic bacteria

01 Feb 2012

publication

Infection-induced hematopoiesis: a zebrafish perspective

10 Nov 2011

publication

Studying cell behavior in whole zebrafish embryos by confocal live imaging: application to hematopoietic stem cells

15 Sep 2011

publication

Strategies of professional phagocytes in vivo: unlike macrophages, neutrophils engulf only surface-associated microbes.

03 Feb 2011

publication

Whole-body analysis of a viral infection: vascular endothelium is a primary target of infectious hematopoietic necrosis virus in zebrafish larvae.

03 Nov 2010

publication

In vivo analysis of Ifn-γ1 and Ifn-γ2 signaling in zebrafish

14 Feb 2010

publication

Blood stem cells emerge from aortic endothelium by a novel type of cell transition

01 Sep 2009

publication

Real-time observation of listeria monocytogenes-phagocyte interactions in living zebrafish larvae.

28 Aug 2009

publication

The two groups of zebrafish virus-induced interferons signal via distinct receptors with specific and shared chains

05 Feb 2009

publication

A large new subset of TRIM genes highly diversified by duplication and positive selection in teleost fish

01 Jan 2008

publication

In vivo analysis of zebrafish innate immunity

12 Oct 2007

publication

Live imaging of emerging hematopoietic stem cells and early thymus colonization

17 Sep 2007

publication

Origins and unconventional behavior of neutrophils in developing zebrafish.

01 Aug 2007

publication

[The zebrafish reveals the odyssey of hematopoietic precursors in developing vertebrate embryos]

31 May 2007

publication

Imaging of nitric oxide in a living vertebrate using a diamino-fluorescein probe

01 Apr 2007

publication

Identification of the zebrafish IFN receptor: implications for the origin of the vertebrate IFN system

07 Dec 2006

publication

Tracing hematopoietic precursor migration to successive hematopoietic organs during zebrafish development.

01 Jun 2005

publication

Otolith matrix proteins OMP-1 and Otolin-1 are necessary for normal otolith growth and their correct anchoring onto the sensory maculae

01 Jan 2005

publication

Imaging early macrophage differentiation, migration, and behaviors in live zebrafish embryos

01 Apr 2004

publication

Focusing light on infection in four dimensions

07 Jan 2004

publication

Nodal and Fgf pathways interact through a positive regulatory loop and synergize to maintain mesodermal cell populations

01 Jan 2003

publication

The zebrafish as a model organism to study development of the immune system

01 Dec 2002

publication

Real-time visualization of mycobacterium-macrophage interactions leading to initiation of granuloma formation in zebrafish embryos

15 Oct 2001

publication

Zebrafish early macrophages colonize cephalic mesenchyme and developing brain, retina, and epidermis through a M-CSF receptor-dependent invasive process

01 Sep 1999

publication

Spinning nuclei in the brain of the zebrafish embryo

01 Sep 1999

publication

Ontogeny and behaviour of early macrophages in the zebrafish embryo

01 Sep 1993

publication

Processing of linear elements in stereopsis: effects of positional and orientational distinctiveness

01 Dec 1990

publication

Synergistic activation of eukaryotic transcription: the multiacceptor target hypothesis

01 Nov 1990

publication

From gene to chromosome: organization levels defined by the interplay of transcription and replication in vertebrates

01 Apr 1990

publication

Anatomy of the rat albumin promoter

01 Nov 1989

publication

The rat albumin promoter is composed of six distinct positive elements within 130 nucleotides

01 Jun 1989

publication

Control elements situated downstream of the major transcriptional start site are sufficient for highly efficient polyomavirus late transcription

14 Aug 1987

publication

Factors involved in control of tissue-specific expression of albumin gene

01 Jul 1987

publication

Determinants of rat albumin promoter tissue specificity analyzed by an improved transient expression system

01 Dec 1984

publication

Two distinct enhancers with different cell specificities coexist in the regulatory region of polyoma

01 Nov 1984

publication

Tissue-specific expression is conferred by a sequence from the 5′ end of the rat albumin gene

01 Jan 1983

publication

Structure and function of the promoter-enhancer region of polyoma and SV40

01 Sep 1982

publication

Physical and biological features of polyoma virus mutants able to infect embryonal carcinoma cell lines

01 Sep 1981

publication

Fine structure of the origin-proximal DNAase I-hypersensitive region in wild-type and EC mutant polyoma

24 Nov 1980

publication

A little guide for advanced search:

Alcam-a and Pdgfr-α are essential for the development of sclerotome-derived stromal cells that support hematopoiesis.

A dual involvement of Protocadherin 18a in stromal cell development guides the formation of a functional hematopoietic niche.

Trim33 conditions the lifespan of primitive macrophages and onset of definitive macrophage production.

The cationic amino acid exporter Slc7a7 is induced and vital in tissue macrophages with sustained efferocytic activity.

Coronin 1A depletion restores the nuclear stability and viability of Aip1/Wdr1-deficient neutrophils

Resident Macrophage Lookalikes of Unexpected Origin

Ultraspecific live imaging of the dynamics of zebrafish neutrophil granules by a histopermeable fluorogenic benzochalcone probe

Live Tracking of Inter-organ Communication by Endogenous Exosomes In Vivo

Anisotropic organization of circumferential actomyosin characterizes hematopoietic stem cells emergence in the zebrafish.

A Model of Superinfection of Virus-Infected Zebrafish Larvae: Increased Susceptibility to Bacteria Associated With Neutrophil Death

Department seminar by Professor David Traver, University of California San Diego: “Developmental regulation of hematopoietic stem cells”

Trim33 / Tif1-γ is essential for macrophage and neutrophil mobilisation to developmental or inflammatory cues

Imaging of viral neuroinvasion in the zebrafish reveals that Sindbis and chikungunya viruses favour different entry routes.

SEMINAR ” Cellular and developmental mechanisms controlling germ cell migration in zebrafish “

SEMINAR “Decoding blood vessels homeostasis : ros signaling, hemodynamics and more”

SEMINAR ” Life and Near Death Experiences at the Cellular Level “

Mutations in CDC14A, Encoding a Protein Phosphatase Involved in Hair Cell Ciliogenesis, Cause Autosomal-Recessive Severe to Profound Deafness

SEMINAR “Mechanisms of macrophage tissue infiltration”

NACA deficiency reveals the crucial role of somite-derived stromal cells in haematopoietic niche formation

Zebrafish facility

Developmental hematopoiesis, from stem cells emergence to tissue resident leukocytes

Behaviour of macrophages and neutrophils in vivo

Contrasted innate responses to two viruses in zebrafish: insights into the ancestral repertoire of vertebrate IFN-stimulated genes.

Zebrafish midbrain slow-amplifying progenitors exhibit high levels of transcripts for nucleotide and ribosome biogenesis

Pivotal role of Pten in the balance between proliferation and differentiation of hematopoietic stem cells in zebrafish

The zebrafish as a new model for the in vivo study of Shigella flexneri interaction with phagocytes and bacterial autophagy

Real-time whole-body visualization of Chikungunya Virus infection and host interferon response in zebrafish.

Localized bacterial infection induces systemic activation of neutrophils through Cxcr2 signaling in zebrafish

Generating parabiotic zebrafish embryos for cell migration and homing studies

Bcl-wav and the mitochondrial calcium uniporter drive gastrula morphogenesis in zebrafish

Inflammatory chemokines direct and restrict leukocyte migration within live tissues as glycan-bound gradients

A new zebrafish model of oro-intestinal pathogen colonization reveals a key role for adhesion in protection by probiotic bacteria

Infection-induced hematopoiesis: a zebrafish perspective

Studying cell behavior in whole zebrafish embryos by confocal live imaging: application to hematopoietic stem cells

Strategies of professional phagocytes in vivo: unlike macrophages, neutrophils engulf only surface-associated microbes.

Whole-body analysis of a viral infection: vascular endothelium is a primary target of infectious hematopoietic necrosis virus in zebrafish larvae.

In vivo analysis of Ifn-γ1 and Ifn-γ2 signaling in zebrafish

Blood stem cells emerge from aortic endothelium by a novel type of cell transition

Real-time observation of listeria monocytogenes-phagocyte interactions in living zebrafish larvae.

The two groups of zebrafish virus-induced interferons signal via distinct receptors with specific and shared chains

A large new subset of TRIM genes highly diversified by duplication and positive selection in teleost fish

In vivo analysis of zebrafish innate immunity

Live imaging of emerging hematopoietic stem cells and early thymus colonization

Origins and unconventional behavior of neutrophils in developing zebrafish.

[The zebrafish reveals the odyssey of hematopoietic precursors in developing vertebrate embryos]

Imaging of nitric oxide in a living vertebrate using a diamino-fluorescein probe

Identification of the zebrafish IFN receptor: implications for the origin of the vertebrate IFN system

Tracing hematopoietic precursor migration to successive hematopoietic organs during zebrafish development.

Otolith matrix proteins OMP-1 and Otolin-1 are necessary for normal otolith growth and their correct anchoring onto the sensory maculae

Imaging early macrophage differentiation, migration, and behaviors in live zebrafish embryos

Focusing light on infection in four dimensions

Nodal and Fgf pathways interact through a positive regulatory loop and synergize to maintain mesodermal cell populations

The zebrafish as a model organism to study development of the immune system

Real-time visualization of mycobacterium-macrophage interactions leading to initiation of granuloma formation in zebrafish embryos

Zebrafish early macrophages colonize cephalic mesenchyme and developing brain, retina, and epidermis through a M-CSF receptor-dependent invasive process

Spinning nuclei in the brain of the zebrafish embryo

Ontogeny and behaviour of early macrophages in the zebrafish embryo

Processing of linear elements in stereopsis: effects of positional and orientational distinctiveness

Synergistic activation of eukaryotic transcription: the multiacceptor target hypothesis

From gene to chromosome: organization levels defined by the interplay of transcription and replication in vertebrates

Anatomy of the rat albumin promoter

The rat albumin promoter is composed of six distinct positive elements within 130 nucleotides

Control elements situated downstream of the major transcriptional start site are sufficient for highly efficient polyomavirus late transcription

Factors involved in control of tissue-specific expression of albumin gene

Determinants of rat albumin promoter tissue specificity analyzed by an improved transient expression system

Two distinct enhancers with different cell specificities coexist in the regulatory region of polyoma

Tissue-specific expression is conferred by a sequence from the 5′ end of the rat albumin gene

Structure and function of the promoter-enhancer region of polyoma and SV40

Physical and biological features of polyoma virus mutants able to infect embryonal carcinoma cell lines

Fine structure of the origin-proximal DNAase I-hypersensitive region in wild-type and EC mutant polyoma

[Fidelity of a polymerization reaction according to the proximity to equilibrium]