Link to Pubmed [PMID] – 31112695
Dev. Cell 2019 May;49(4):501-502
In this issue of Developmental Cell, Lin et al. (2019) identify in zebrafish skin macrophage-like cells that sample the environment through transepithelial protrusions and import antigen from the water for traditional tissue-resident macrophages. Remarkably, these “metaphocytes” originate from the epidermis, challenging current assumptions about the lineage of tissue-resident macrophages.