About
Yersinia pestis is the highly infectious Gram-negative bacterium that causes plague, which is responsible for the most devastating pandemics in human history. Three main clinical forms include the most common bubonic plague resulting from the bite of an infected flea, the pneumonic plague transmitted from human to human by aerosols and the most fulminating, fatal septicemic plague. Bacteria ultimately disseminate in the bloodstream and lead to rapid death of the host in the three forms of the disease. Using a systems biology approach, combining multi-omics data visualization and functional proteomics, our aim is to identify bacterial and host determinants involved in the bacteremic phase of plague.
