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Content 2
  • member
  • team
  • department
  • center
  • program_project
  • nrc
  • whocc
  • project
  • software
  • tool
  • patent
  • Administrative Staff
  • Assistant Professor
  • Associate Professor
  • Clinical Research Assistant
  • Full Professor
  • Graduate Student
  • Lab assistant
  • Non-permanent Researcher
  • Permanent Researcher
  • Pharmacist
  • PhD Student
  • Physician
  • Post-doc
  • Project Manager
  • Research Associate
  • Research Engineer
  • Retired scientist
  • Technician
  • Undergraduate Student
  • Veterinary
  • Visiting Scientist
  • Deputy Director of Center
  • Deputy Director of Department
  • Deputy Director of National Reference Center
  • Deputy Head of Facility
  • Director of Center
  • Director of Department
  • Director of Institute
  • Director of National Reference Center
  • Group Leader
  • Head of Facility
  • Head of Operations
  • Head of Structure
  • Honorary President of the Departement
  • Labex Coordinator
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Starting Date
01
Oct 2015
Ending Date
01
Oct 2027
Status
Ongoing
Members
8
Structures
1

About

Vaccination is one of the greatest successes of modern medicine. The first generation of viral vaccines relied on empiric attenuation by repeated passage in animals and/or cultured cells. A successful attenuation process eliminates virulence without losing viral immunogenicity. Vaccines against yellow fever virus, varicella, measles, mumps and rubella are examples of successful live attenuated vaccines (LAVs). Astonishingly, despite such triumphs, we have very little understanding of the mechanisms by which viruses lose their capacity to produce disease.

We are studying LAVs as models to understand key features of viral attenuation in mammalian cells and, when relev
ant, in arthropod vectors. Such studies are crucial for rational design of live attenuated viral vaccines and better understanding of virus-host interaction. 

Fundings