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About

Lulla Opatowski is assistant professor in Mathematical Epidemiology (University of Versailles Saint Quentin – UVSQ).
Her main research interests are in mathematical modelling of infectious disease and statistical inference, with a particular interest in bacterial resistance to antimicrobials (including antibiotics and vaccines) and host-pathogen-pathogen interactions.

Her main projects include:

  • RESPIMOD: Modelling between-pathogen interactions within the respiratory tract, in particular interactions between Streptococcus pneumoniae and respiratory viruses.
  • CHART: characterisation of the transmission of Enterobacteriaceae resistant to 3rd generation cephalosporin in hospitalized neonates in Antananarivo Madagascar.
  • Microbiome: Building models to study the factors leading to the acquisition of antibiotic resistant bacteria and the development of gut microbiota in neonates.
  • Nosocomial infections: modelling analysis of different outbreaks of antibiotic-resistant bacteria in hospitals. This includes in particular the analysis of strains transmission from detailed proximity contact data and colonisation of S. aureus and Enterobacteriaceae (I-BIRD study, Individual Based Investigation of Resistant bacteria Dissemination in hospitals)
  • Study of multi-strain models and impact of vaccination (application to pneumococcus and HPV)

 

Team members:

  • Matthieu Domenech de Celles
  • Hélène Arduin 
  • Audrey Duval 
  • Jonathan Bastard
  • Mélanie Bonneault

Projects

CV

ACADEMIC BACKGROUND

2005 – 2009         PhD in Biomathematics – Public Health: Epidemiology and science of biomedical information. University Pierre and Marie Curie, Paris VI, ED 393.

2000 – 2003         Engineer ENSIMAG (Graduate School of Engineering in Applied Mathematics and Computer Science, French equivalent for Master of Computer Science and Applied Mathematics) –  Grenoble, France

2002 – 2003         Licenciatura in University of mathematics and statistics (5th year) member of UPC (Universitat Politécnica de Catalunya), Barcelona, Spain

1997 – 2000         Special intensive courses of advanced mathematics and physics (undergraduate level)

           

SCIENTIFIC ACTIVITIES

Research

From Sep 2012                   Maître de conferences (eq. assistant professor) at Versailles Saint Quentin University, Biostatistics, Biomathematics, Pharmaco-epidemiology and Infectious Disease research Unit (B2PHI) UMR1181, Institut Pasteur / INSERM /UVSQ, France.
Mathematical Modelling and statistical inference of the pathogen-pathogen and host-pathogen interactions.

› Pathogen interactions within the host for colonisation and infection (nasopharynx & gut)

› Antibiotic-resistance 

› Multi-strain transmission in the human community, ecological aspects and risk of ecological replacement following drug (antibiotic or vaccine) introduction

July 2009-Sep 2012          Research Associate (POST DOC). MRC Centre for Outbreak Analysis and Modelling, Department of Infectious Disease Epidemiology, Imperial College, London. Mathematical modelling and statistical inference for a better understanding of the spread of pathogens in populations.

2005 – 2009         PhD. Institut Pasteur / U657 INSERM (National Institute of Health and Medical Research), Pharmaco-Epidemiology applied to Infectious Diseases laboratory (PhEMI)

Juil 2003 – Oct. 2004       Assistante Professor. CRG (Centre of Genomic Regulation), Microarrays Laboratory  and GRIB (Group of Research in Bio-medicine and Computer Science), Chemogenomics Laboratory – Barcelona, Spain

Teaching

2012-.  UVSQ, MSc students in Epidemiology and Biology. Biostatistics and mathematical modelling.

2011       Imperial College London, MSc of Public Health Epidemiology. Tutoring of practical for Bayesian statistics (WinBUGS) & Introductive lecture on imperfect vaccines

2008        Cnam (Conservatoire National des Arts et Métiers) – Paris, France. Mathematical and statistical tools for the health and security at work and environment

2005-2008             Paris VI School of Medicine – Paris, France. Assistant Professor biostatistics courses for medical students

2005, 2006            Pharmaco-epidemiology, Pasteur school for Infectiology, Institut Pasteur. Introduction to biostatistics and R

2004        UPF (Pompeu Fabra University) – Barcelona, Spain. Assistant Professor in the University of life and health sciences for bio-mathematics and bio-statistics courses (level: 1rst and 3rd years of university)

Supervision

2016-2017            Post-doctoral fellow Xuefeng Gao

2015-.                    Post-doctoral fellow M Domenech de Celles

2017-.                    Co-supervision of a PhD thesis on mathematical modelling of animal/human transmission of antibiotic resistant bacteria / Jonathan Bastard, Institut Pasteur

2017-.                    Co-supervision of a PhD thesis on mathematical modelling of Human Papillomavirus infections and cancer / Mélanie Bonneault, UVSQ, (funding Institute for cancer research)

2016-.                    Co-supervision of a PhD thesis on mathematical modelling of nosocomial infections / Audrey Duval, UVSQ

2015-.                    Co-supervision of a PhD thesis on mathematical modelling of nosocomial infections / Rania Assab, Cnam

2014-18                Supervision of a PhD thesis on mathematical modelling of pathogen interactions / Hélène Arduin, UVSQ

2005-.                    Supervising of >15 students from MSc and engineer school for their 6-months projects,  PhEMI, Institut Pasteur

2009-2013            Participation in supervision of PhD research on modelling HPV ecology of Margarita Pons Salort, together with Didier Guillemot (PhEMI) and Véronique Letort (Ecole Centrale Paris)

2009-2013            Participation in supervision of PhD research on estimation of bacteria’s epidemicity in hospitals and the community of Matthieu Domenech de Celles, together with Didier Guillemot (PhEMI)

Since 2008           Supervision, all through the academic year, of groups of students (2-6) from Ecole Centrale Paris for their projects ( “innovation” and “enjeux” projects)

 

GRANTS AND AWARDS

2002-2003            Grant for mobility, Rhône Alps region

2005                       AReMIS project, joint INSERM-CNRS-INRIA grant on « Information and Technologies for health » 

2008                       GlaxoSmith Kline award on public health

2012                       BQR from UVSQ in collaboration with S. Ben Amor, A. Bui et N. Emad (PRISM lab, UVSQ) 

2013-16                ACIP (action concertée inter pasteurienne), Institut Pasteur, project in collaboration with S. Breurec et B. Guarin  on  « Modeling the transmission of antibiotic-multi-resistant bacteria in neonates wards in two hopspital contexts : the République Centrafricaine et Madagascar» (co-PI)

2015-17                RESPIMOD project (DIM Malinf) grant for a 18 months post-doctoral funding (PI)

2015-17                PTR Microbiome, in collaboration with P. Glaser (Institut Pasteur Paris) and Institut Pasteur de Madagascar. Study of the dynamic of microbiota in infants and factors at the origin of resistant bacteria acquisition. (co-PI).

2017-19                Modelling the trends of Meningococcal (MenW ) infections in France and assessing the impact of vaccination, research grant from Pfizer (PI)

2018-20                PANDORE: Prediction of antibiotic resistance in environments. Funded by ANSES (National Agency for health security). Collaborations C Dagot, F Petit, J Labanowski, E Moreau-Guigon (co-PI).

2018-21                SPHINX: Multi-scale modelling of infection spread in health care facilities. Funded by Agence Nationale de la recherche (National Research Agency – France). Collaborations L Temime, P Crepey, V Colliza and P Astagneau (co-PI).

 

MISCELLANEOUS

2018 (July)          Co-organizer, Joint Pasteur-Oxford workshop on antibiotic resistance in South East Asia

2018 (March)     Co-organizer, International conference on antimicrobial resistance, Institut Pasteur France

Since Sept 2013 Co-organisation of the SaMMBA monthly seminars (Statistical and Mathematical Modeling in Biological Applications) at Institut Pasteur in Paris ( https://research.pasteur.fr/en/project/sammba-seminars/), funding ANRS, Dim Systèmes complexes (Ile de France region) and INRA

May 2012            Organisation of the WARM international workshop on modelling bacterial resistance in Paris (http://warm2012.cnam.fr/). 2-day workshop, 18 invited international speakers, 100 participants, free, funded by the Ile de France region (DIM Malinf), the UVSQ, the Cnam and the European consortium MOSAR, whole budget 16 000 euros)

Reviewing activities        Epidemics, BMC Infectious Diseases, PLoS ONE, Epidemiology, American Journal of Epidemiology, PLoS Computational Biology, JR Soc Interface, Influenza and other Resp., BMJ Open …

Expertise activities         

Expertise for project evaluation for JEAI program, Institut Recherche et Développement (IRD) and for FINOVI (Rhones Alps region)

Since 2016           Expertise for World Health Organization (WHO) – Asia on antibiotic resistance

Since 2013           Elected member of the scientific board of the UFR Simone Veil Medical school

Since 2017           Nominated member of Comité Scientifique de l’ITMO “Immunologie-Inflammation-infectiologie-Microbiologie” (I3M)

Since 2017           Elected member (deputy) COMESP Institut Pasteur evaluation committee

 

 

Publications