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About

Lulla Opatowski is professor in Mathematical Epidemiology (University of Versailles Saint Quentin – UVSQ). Her main research interests are in mathematical modelling of infectious disease and statistical inference, with a particular interest in bacterial resistance to antimicrobials (including antibiotics and vaccines) and host-pathogen-pathogen interactions. Her main projects include:

  • SARS-COV-2, MOD-COV: We currently participate to the modelling effort on COVID and in particular study the risk of transmission of the virus in health care settings within patients and health care workers
  • RESPIMOD: Modelling between-pathogen interactions within the respiratory tract, in particular interactions between Streptococcus pneumoniae and respiratory viruses.
  • Microbiome: Building models to study the factors leading to the acquisition of antibiotic resistant bacteria and the development of gut microbiota.
  • Nosocomial infections: modelling analysis of antibiotic-resistant bacteria in hospitals. This includes both theoretical models and the analysis of strains transmission routes from detailed proximity contact data and colonisation of S. aureus and Enterobacteriaceae (I-BIRD study, Individual Based Investigation of Resistant bacteria Dissemination in hospitals)
  • Study of multi-strain models and impact of vaccination (application to pneumococcus and HPV)
  • One health: Modelling selection and persistence of antibiotic resistance genes in effluents

Team members:

  • Mélanie Bonneault
  • Sophie Chervet
  • Aleksandra Kovacevic
  • Ajmal Oodally
  • Eve Rahbe
  • George Shirreff
  • David Smith

Former team members:

  • Hélène Arduin
  • Jonathan Bastard
  • Audrey Duval
  • Xuefeng Gao
  • Rania Assab
  • Matthieu Domenech de Celles
  • Pachka Hammami
  • Paul Henriot

Transversal Projects

Fighting Antibiotic Resistance

Antibiotics are highly efficient drugs to kill pathogenic bacteria with low side effects. For more than 70 years, the massive use of these miracle drugs has saved millions of human and animal lives. Unfortunately […]

INCEPTION – Institut Convergence for the study of Emergence of Pathology Through Individuals and Populations

IINCEPTION Goal The Inception’s goal is to develop a core structure to mobilize data resources, numerical sciences, and fundamental experimental biology in a range of health issues (Official website here : https://www.inception-program.fr/en). Inception program […]

Projects

Project
Ongoing
4 Members

NeoLIC

Bich-Tram Huynh (PI)

Neonatal acquisition of ESBL-PE in the community of a Low-Income Country  Severe bacterial infections are a leading cause of neonatal deaths, with low income countries (LICs) bearing the highest burden. In LICs, neonatal bacterial […]
Project
Ongoing
4 Members

MOD-COV

Lulla Opatowski (PI)

Project MOD-COV (Modelling of the hOspital Dissemination of SARS-CoV-2) In the context of SARS-CoV-2 pandemic, healthcare institutions are confronted to major challenges. First the community spread is leading to a large demand in available […]
Project
Ongoing
4 Members

SocialCov – Enquête contacts SARS-CoV-2

Lulla Opatowski (PI)

Cliquer ici pour aller à l’enquête Confinement, mesures barrières, limitation des rassemblements etc. Les mesures de prévention actuellement mises en place sont inédites. Elles ont fondamentalement modifié les contacts que nous avons au quotidien. […]
Project
Ongoing
2 Members

SPHINx (Spread of Pathogens on Healthcare Institutions Networks)

Lulla Opatowski (PI)

Healthcare-associated infections (HAI) have been occurring with increased incidence and severity over the last decades, becoming a major public health issue. A wide range of control strategies is already available, including hygiene measures, barrier […]
Project
Ongoing
2 Members

Pandore – modelling antibiotic resistance in effluents

Lulla Opatowski (PI)

Our group is in charge of the modelling workpackage of the Pandore project (Prédiction de l’ANtibiorésistance dans Des zOnes anthRopisées Environnementales), which aims at investigating the dynamics of antibiotic resistance genes in waters and […]
Project
Ongoing
2 Members

SARAH (Spread of Antimicrobial Resistance between Animals and Humans)

Lulla Opatowski (PI)

The main objective of the SARAH project is to study the determinants of antibiotic resistant bacteria dissemination at the animal-human interface. We develop a methodological research based on mathematical modelling and the analysis of […]
Project
Ongoing
5 Members

MedVetKlebs: Klebsiella pneumoniae from ecology to source attribution and transmission control

Sylvain Brisse (PI)

Klebsiella pneumoniae (hereafter, K. pneumoniae) is a major cause of hospital-acquired infections such as urinary infections, pneumonia, bloodstream infections, infections in newborns and in intensive-care unit patients. Some hypervirulent strains also cause community infections […]
Project
Ongoing
5 Members

Modelling Infection Spread in Hospitals

Lulla Opatowski (PI)

Despite advances in modern biology and medicine, antibiotic-resistant bacteria (ARB) have spread in the community and in hospitals over the last decades, becoming a major public health problem. Mathematical modeling and computer simulations are […]
Project
Ongoing
3 Members

RESPIMOD: Modelling Interactions within Respiratory Tract

Lulla Opatowski (PI)

Invasive pneumococcal diseases (IPDs) are a major cause of morbidity and mortality worldwide. The mechanisms responsible for the epidemiological patterns of susceptible- and resistant- IPDs which include a yearly winter peak are still poorly […]
Project
Ongoing
4 Members

I-BIRD: Individual Based Investigation of Resistance Dissemination

Didier Guillemot (PI)

The i-Bird program was devoted to explore the ability of MRSA and ER3GC to disseminate within hospital clinical departments. This program involved tracing the clonal dissemination of MRSA and ER3GC among hospitalized patients and […]
Project
Ongoing
4 Members

Dynamics of Gut Microbiota

Philippe Glaser (PI)

Acquisition of antibiotic resistant bacteria and development of the gut microbiome in neonates in low-income countries. Antibiotic resistance represents a major health issue worldwide. The situation is particularly acute in low-income countries (LIC), due […]
Project
Ongoing
4 Members

CHART: Bacterial Acquisition Routes In Neonates

Lulla Opatowski (PI)

Children’s Antibiotic Resistance colonization and Route of Transmission. The aim of this program is to assess the transmission of enterobacteria resistant to 3rd generation cephalosporines (EBRCIIIG) in hospitalized neonates in two low income countries […]
Project
Ongoing
6 Members

Antiinfectives drugs and invasive pneumococcal diseases

Laurence Watier (PI)

In addition to a direct effect on the individual, the consumption of antiinfective drugs may have an indirect ecological benefit only visible at the population level. Moreover indirect ecological adverse effects may also exist […]
Project
Ongoing
3 Members

SaMMBA Seminars

Lulla Opatowski (PI)

Statistical and Mathematical Modeling in Biological Applications — SaMMBA The seminars have started again on March 16th ! The organization has been adapted to the current outbreak situation. They are currently online (link provided […]

CV

ACADEMIC BACKGROUND
2018                HDR in Biomathematics - Habilitation à diriger des recherches, Paris Saclay University, UVSQ
2005 – 2009         PhD in Biomathematics - Public Health: Epidemiology and science of biomedical information. University Pierre and Marie Curie, Paris VI, ED 393.
2000 – 2003         Engineer ENSIMAG (Graduate School of Engineering in Applied Mathematics and Computer Science, French equivalent for Master of Computer Science and Applied Mathematics) –  Grenoble, France
2002 – 2003         Licenciatura in University of mathematics and statistics (5th year) member of UPC (Universitat Politécnica de Catalunya), Barcelona, Spain
1997 – 2000 Special intensive courses of advanced mathematics and physics (undergraduate level)  

LABS
- 2012-.  Assistant professor > Professor. Versailles Saint Quentin University, EMEA unit UMR1018, Institut Pasteur / INSERM /UVSQ, France. 
Mathematical Modelling and statistical inference of the dynamics of transmission of pathogens in population, with a focus on pathogen-pathogen, host-pathogen interactions, and antimicrobial resistance.
- 2009-12 Research Associate (POST DOC). MRC Centre for Outbreak Analysis and Modelling, Department of Infectious Disease Epidemiology, Imperial College, London. Mathematical modelling and statistical inference for a better understanding of the spread of pathogens in populations.
- 2005–09 Institut Pasteur / U657 INSERM, Pharmaco-Epidemiology applied to Infectious Diseases laboratory (PhEMI)
- 2003–04 CRG (Centre of Genomic Regulation), Microarrays Laboratory and GRIB (Group of Research in Bio-medicine and Computer Science), Chemogenomics Laboratory – Barcelona, Spain

CONFERENCE ORGANISATION/CO-ORGANISATION
2019    SPHINx conference on disease transmission in healthcare settings
2018    Joint Pasteur-Oxford workshop on antibiotic resistance in South East Asia2018 
2018    International conference on antimicrobial resistance, Institut Pasteur 
2013-.  SaMMBA monthly seminars - Statistical and Mathematical Modeling in Biological Applications, Institut Pasteur in Paris ( https://research.pasteur.fr/en/project/sammba-seminars/)
2012     WARM international workshop on modelling bacterial resistance in Paris 

Expertise activities
Since 2016  Expertise for World Health Organization (WHO) - Asia on antibiotic resistance
Since 2013  Elected member of the scientific board of the UFR Simone Veil Medical school
Since 2017  Nominated member of Comité Scientifique de l'ITMO "Immunologie-Inflammation-infectiologie-Microbiologie" (I3M)
Since 2017  Elected member COMESP Institut Pasteur evaluation committee

Publications

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