Guilherme Dias de Melo is veterinarian. He obtained his degree in Veterinary Medicine (december 2010), his MD in Veterinary Sciences (june 2012) and his PhD in Veterinary Sciences (june 2015) at the Sao Paulo State University – Araçatuba, Brazil. He is currently a Researcher at the Lyssavirus Epidemiology and Neuropathology Unit.
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About
Courses
Rabies MOOC
This course explains the pathophysiology, epidemiology, vaccines and elimination strategies of the rabies virus. >> Register here << Rabies is a fatal encephalitis caused by a Lyssavirus primarily transmitted by the bite or scratch […]
2024-08-08 09:00:00
2025-09-30 23:00:00
Europe/Paris
Rabies MOOC
This course explains the pathophysiology, epidemiology, vaccines and elimination strategies of the rabies virus. >> Register here << Rabies is a fatal encephalitis caused by a Lyssavirus primarily transmitted by the bite or scratch […]
Projects
Former Teams
CV
Education
| Year | Degree | Field | Institution |
| 2012-2015 | PhD | Veterinary Science | Sao Paulo State University, Araçatuba-SP, Brazil |
| 2011-2012 | MSc | Veterinary Science | Sao Paulo State University, Araçatuba-SP, Brazil |
| 2006-2010 | DVM | Veterinary Medicine | Sao Paulo State University, Araçatuba-SP, Brazil |
Training
| Year | Field | Institution |
| 2014-2015 | Immunology/Parasitology | Trypanosomatids Infectious Processes, Institut Pasteur, Paris, France |
| 2011-2011 | Veterinary Pathology | Institut of Veterinary Pathology, Justus-Liebig University, Giessen, Germany |
Postdoctoral Training
- 2018-2022 – Lyssavirus Epidemiology and Neuropathology Unit, Institut Pasteur, Paris, France
- 2015-2017 – Trypanosomatids Infectious Processes, Institut Pasteur, Paris, France
Awards and Grants
- 2022 – International Prize in Planetary Health. Université Franco-Allemande – Lyon, France
- 2006-2015 – Fellow of Sao Paulo Research Foundation (FAPESP, Fundação de Amparo à Pesquisa do Estado de São Paulo) (DVM #2006/56724-3; MSc #2010/12473-2; PhD #2012/10415-0)
- 2013 – ICI-AAI Travel Grant for Immunologists from Developing Countries – 15th International Congress of Immunology (ICI) – Milan, Italy
- 2013 – Best poster in Cellular and Molecular Biology – Fifth World Congress on Leishmaniasis (World Leish 5) – Porto de Galinhas, Brazil
- 2011 – Travel Grant – 11th European School of Neuroimmunology (ESNI), Glasgow, Scotland
Publications
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2025Hamsters with long COVID present distinct transcriptomic profiles associated with neurodegenerative processes in brainstem, Nat Commun 2025 Jul; 16(1): 6714.
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2025The SARS-CoV-2 envelope PDZ binding motif acts as a virulence factor disrupting host’s epithelial cell–cell junctions [brief report], Cellular and Molecular Biology Letters, 2025, 30 (1), pp.80. ⟨10.1186/s11658-025-00758-y⟩.
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2024Mechanism of action of phthalazinone derivatives against rabies virus., Antiviral Res 2024 Apr; 224(): 105838.
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2023Neuroinvasion and anosmia are independent phenomena upon infection with SARS-CoV-2 and its variants., Nat Commun 2023 Jul; 14(1): 4485.
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2022Susceptibilities of CNS Cells towards Rabies Virus Infection Is Linked to Cellular Innate Immune Responses., Viruses 2022 Dec; 15(1): .
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2022Potent human broadly SARS-CoV-2-neutralizing IgA and IgG antibodies effective against Omicron BA.1 and BA.2., J Exp Med 2022 Jul; 219(7): .
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2021A live measles-vectored COVID-19 vaccine induces strong immunity and protection from SARS-CoV-2 challenge in mice and hamsters., Nat Commun 2021 Nov; 12(1): 6277.
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2021Attenuation of clinical and immunological outcomes during SARS-CoV-2 infection by ivermectin., EMBO Mol Med 2021 Aug; 13(8): e14122.
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2021COVID-19-related anosmia is associated with viral persistence and inflammation in human olfactory epithelium and brain infection in hamsters., Sci Transl Med 2021 Jun; 13(596): .
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2020A combination of two human monoclonal antibodies cures symptomatic rabies., EMBO Mol Med 2020 Sep; (): e12628.
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