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  • whocc
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  • Assistant Professor
  • Associate Professor
  • Clinical Research Assistant
  • Full Professor
  • Graduate Student
  • Lab assistant
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  • Permanent Researcher
  • Pharmacist
  • PhD Student
  • Physician
  • Post-doc
  • Project Manager
  • Research Associate
  • Research Engineer
  • Retired scientist
  • Technician
  • Undergraduate Student
  • Veterinary
  • Visiting Scientist
  • Deputy Director of Center
  • Deputy Director of Department
  • Deputy Director of National Reference Center
  • Deputy Head of Facility
  • Director of Center
  • Director of Department
  • Director of Institute
  • Director of National Reference Center
  • Group Leader
  • Head of Facility
  • Head of Operations
  • Head of Structure
  • Honorary President of the Departement
  • Labex Coordinator
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Scientific Fields
Diseases
Organisms
Applications
Technique
Starting Date
02
Apr 2020
Status
Ongoing
Members
5

About

The research activities of our group focus on the understanding of the complex relationship between immunity and neural functions during rabies virus (RABV) infection, which should ultimately help in the comprehension of viral encephalitis physiopathology that could be shared with other neurotropic viruses. Brain-connectivity-and-neurodegenerative-diseases

Major Federating Program Microbes & Brain

Our team holds a large experience in the production of recombinant and mutant RABV, in development of antiviral therapy, in animal models and in culturing primary neuronal and glial cells in different supports and devices in order to investigate host-rabies virus interaction. It has also developed a strong expertise in studying the capacity of RABV to modulate the innate immune response during the early steps of infection.

The most relevant objectives of our group are

  1. to decrypt the dynamics of cooperation between the different human brain cells (mainly neurons, astrocytes and microglial cells) during RABV infection;
  2. to determine how the crosstalk between these cells, in particular glial cells and neurons, is correlated with the dysfunction of neurons, and
  3. to decipher how RABV spread affects the neural network connectivity using mice models, organ on chip model, single cell sequencing, proteomics, high-throughput fluorescence microscopy and multielectrode arrays readouts on RABV-infected neural networks.