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  • Director of Center
  • Director of Department
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Scientific Fields
Diseases
Organisms
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Projects

Project
Ongoing
5 Members

Mutations in PDZ Binding Motif (PBM)-containing proteins associated to the Usher syndrome

Nicolas Wolff (PI)

Mutations in PDZ Binding Motif (PBM)-containing proteins are also associated to the Usher syndrome, a genetic disease resulting in both hearing loss and visual impairment. Most Usher proteins are present in auditory hair cells […]
Project
Ongoing
7 Members

Bacterial Transmembrane Signaling

Nadia Izadi-Pruneyre (PI)

Bacteria display several mechanisms to adapt to their host-environment and successfully colonise it. One important mechanism of adaptation concerns the regulation of gene expression in response to external signals such as the presence of […]

CV

Professional experience

  • Since 2024: Chargé de Recherche CRHC CNRS, UMR 3528, Institut Pasteur, Paris.
  • Since 2018: Chargé de Recherche CRCN CNRS, UMR 3528, Structural Bioinformatics Unit (M. Nilges) and Biological NMR Technological Platform (I. Guijarro), Institut Pasteur, Paris.
  • 2004: Chargé de Recherche CR1 CNRS, UMR 3528, NMR of Biomolecules Unit (M. Delepierre), Group Signalling and Molecular Interactions (N. Wolff), Institut Pasteur, Paris.
  • 1999-2004: Research associate position, Biozentrum/Basel University (S. Grzesiek Lab) – Switzerland.
  • 1998-1999: Postdoctoral fellowship from the Alexander von Humboldt Foundation, Structural Biology Dpt/Forschungszentrum Jülich (S. Grzesiek Lab) – Germany.
  • 09/1996 – 11/1996: Three-month stay at the University of Cincinnati College of medicine (M. Rance Lab), Ohio, USA.

Education

  • 1998: PhD in Physics (J. Fourier University), specialization in NMR methodology. Institut de Biologie Structurale (D. Marion Lab), Grenoble.

Main scientific achievements and expertise

  • First direct observation of protein Hydrogen-bonds by NMR scalar couplings.
  • Quantitative and dynamic analysis of protein phosphorylation by NMR.
  • NMR methodology (e.g., multidimensional heteronuclear experiments, protein dynamics, RDC measurements, …).
  • Structures, interactions and dynamics of various biological systems and IDP using NMR and other biophysical approaches, screening.

Publications

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