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Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Journal of virology - 13 Dec 2023

Bolland W, Michel V, Planas D, Hubert M, Staropoli I, Guivel-Benhassine F, Porrot F, N'Debi M, Rodriguez C, Fourati S, Prot M, Planchais C, Hocqueloux L, Simon-Lorière E, Mouquet H, Prazuck T, Pawlotsky J-M, Bruel T, Schwartz O, Buchrieser J

Link to Pubmed [PMID] – 38088562

Link to DOI – 10.1128/jvi.01351-23

J Virol 2023 Dec; (): e0135123

Our results highlight the plasticity of SARS-CoV-2 Spike to generate highly fusogenic and cytopathic strains with the causative mutations being uncharacterized in previous variants. We describe mechanisms regulating the formation of syncytia and the subsequent consequences in a primary culture model, which are poorly understood.