Inserm Unit 1223 (Pathophysiology of the Immune System) comprises four laboratories within the Immunology Department of the Institut Pasteur: Innate Immunity Unit (James Di Santo), Lymphocytes and Immunity Unit (Ana Cumano), Dynamics of Immune Response Unit (Philippe Bousso) and Genome Integrity Immunity and Cancer Unit (Ludovic Deriano). Together, we pursue collaborative projects aiming to better understand lymphocyte development, differentiation and functional dynamics under normal steady-state conditions and during inflammation or infection in mouse and man.
Click to view graph
Connections
About
Groups
Laboratory

Dynamics of Immune Responses

Philippe Bousso
Laboratory

Innate Immunity

James Di Santo
Laboratory

Genome integrity, Immunity and Cancer

Ludovic Deriano
Members
Fundings
Publications
Download-
2025Reprogramming RIPK3-induced cell death in malignant B cells promotes immune-mediated tumor control., Sci Adv 2025 Aug; 11(33): eadv0871.
-
2025Adaptive immune responses to SARS-CoV-2 in DMARD-treated patients with chronic inflammatory rheumatisms., RMD Open 2025 Jul; 11(3): .
-
2025Spatiotemporal dynamics of fetal liver hematopoietic niches., J Exp Med 2025 Feb; 222(2): .
-
2024IL-7-dependent and -independent lineages of IL-7R-dependent human T cells., J Clin Invest 2024 Oct; 134(19): .
-
2024Group 3 innate lymphoid cells: A trained Gutkeeper., Immunol Rev 2024 May; 323(1): 126-137.
-
2024A measles-vectored vaccine candidate expressing prefusion-stabilized SARS-CoV-2 spike protein brought to phase I/II clinical trials: candidate selection in a preclinical murine model., J Virol 2024 Apr; (): e0169323.
-
2024Anti-PD-1 therapy triggers Tfh cell-dependent IL-4 release to boost CD8 T cell responses in tumor-draining lymph nodes., J Exp Med 2024 Apr; 221(4): .
-
2024Bone marrow monocytes sustain NK cell-poiesis during non-alcoholic steatohepatitis, Cell Reports, 2024, 43 (1), pp.113676. ⟨10.1016/j.celrep.2024.113676⟩.
-
2023Divergent roles for STAT4 in shaping differentiation of cytotoxic ILC1 and NK cells during gut inflammation., Proc Natl Acad Sci U S A 2023 Oct; 120(40): e2306761120.
-
2023A major role for CD4+ T cells in driving cytokine release syndrome during CAR T cell therapy, Cell Reports Medicine, 2023, 4 (9), pp.101161. ⟨10.1016/j.xcrm.2023.101161⟩.
-
+View full list of publications