After a PhD in Neuroscience from the University of Lyon-I in 1995, Dr Aziz El-Amraoui joined the Institut Pasteur (Paris) where resorting to dozen identified deafness genes as entry points has enabled him to enlighten both fundamental and medical aspects of hearing & vision functioning and related disorders (https://orcid.org/0000-0003-2692-4984). Multidisciplinary and multiscale approaches owing to the biochemical properties of the encoded proteins, identification of their molecular networks, deep-phenotyping of related animal models have provided major cues for understanding how the inner ear & eye sensory organs develop and function (Jean-Valade Prize 2005, Fond Mazet-Danet Fondation de France, 2006; Chaire of Excellence Charles Nicolle, Institut Pasteur (2017). Building on accurate and well-documented disease pathogenic mechanisms, his team current efforts are focused on late-onset and/or progressive hearing and vision impairments, from pathogenesis to treatment solutions. The major aims of the team are to i) elucidate the origins of disease progression and severity, and ii) identify therapeutic targets and solutions to delay, prevent and/or cure sense(s) deterioration in animal preclinical models, in anticipation of future transfer into clinics.
Orcid : https://orcid.org/0000-0003-2692-4984
Researchgate profile: https://www.researchgate.net/profile/Aziz_El-Amraoui
Website : https://research.pasteur.fr/en/team/progressive-sensory-disorders-pathophysiology-and-therapy/
