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  • Director of Center
  • Director of Department
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About

After a PhD in Neuroscience from the University of Lyon-I in 1995, he joined the Institut Pasteur (Paris) where resorting to dozen identified deafness genes, several of which are involved in Usher syndrome (deafness and blindness in humans), as entry points has enabled him to enlighten both fundamental and medical aspects of hearing & vision functioning and related disorders. Multidisciplinary approaches owing to the biochemical properties of the encoded proteins, identification of their molecular networks, animal modelling of the disease have provided major insights into how the inner ear & eye sensory organs develop an function (Jean-Valade Prize 2005, Fond Mazet-Danet Fondation de France, 2006; Chaire of Excellence Charles Nicolle, Institut Pasteur (2017-2019). In his team “Progressive Sensory Disorders”, the member’s current efforts are focused on late-onset and/or progressive hearing and vision impairments, aiming to i) elucidate the precise underlying pathogenic pathways, and ii) identify therapeutic targets and solutions to delay, prevent and/or cure progressive sense deterioration in animal preclinical models, and accelerate their transfer into clinics.
Orcid : https://orcid.org/0000-0003-2692-4984
Website : https://research.pasteur.fr/en/team/progressive-sensory-disorders-pathophysiology-and-therapy/

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