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About

After my PhD in Neuroscience from the University of Lyon-I in 1995, I joined the laboratory of Professor C. Petit at the Institut Pasteur where resorting to identified deafness genes as an entry point has enabled us to enlighten both fundamental and medical aspects of hearing functioning and related disorders. Multidisciplinary approaches owing to the biochemical properties of the encoded proteins, identification of their molecular networks, animal modelling of the disease have provided major cues for understanding how the hearing organ develops and functions, illustrated by the more than 50 high-level published papers. Over the last 20 years, I contributed to the elucidation of the disease mechanisms of dozen deafness genes, several of which are involved in Usher syndrome (deafness and blindness in humans) (Jean-Valade Prize 2005, Fond Mazet-Danet Fondation de France, 2006; Chaire of Excellence Charles Nicolle, Institut Pasteur  (2017-2019). Through integrative investigations, calling upon genetic, molecular biology, biochemistry, cell imaging, cell biology and physiology studies, we ascertained the involvement of most of these genes in several key processes of hearing and vision, and unraveled the corresponding disease mechanisms. My efforts are now aimed to speed up translating this progress into therapeutic approaches aiming to delay, prevent or cure progressive hearing and/or vision loss in animal preclinical models, and accelerate their transfer into clinics.

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