After graduating as an engineer from Ecole Polytechnique, Jean-Pierre Levraud obtained a PhD in Immunology at Université Pierre et Marie Curie (then Paris VI) in 1997, working on anti-tumor T cell immunity under the direction of Philippe Kourilsky at Institut Pasteur. From 1998 to 2001, he did his post-doc in Marseille in Pierre Golstein’s lab, working on programmed cell death in a distant eukaryote. Back in Pasteur, he turned to the zebrafish as model host to study innate immunity within Philippe Herbomel’s laboratory. In collaboration with many labs, he developed various infection models in zebrafish, notably for viruses. He contributed much to the characterization of the interferon system of zebrafish and to the development of tools to follow viral infections and host immune responses by intravital imaging. He is also the scientific manager of the zebrafish facility.
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2022Exploring Zebrafish Larvae as a COVID-19 Model: Probable Abortive SARS-CoV-2 Replication in the Swim Bladder., Front Cell Infect Microbiol 2022 ; 12(): 790851.
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2021Mining zebrafish microbiota reveals key community-level resistance against fish pathogen infection., ISME J 2021 Mar; 15(3): 702-719.
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2020Spatiotemporal analysis of mycolactone distribution in vivo reveals partial diffusion in the central nervous system., PLoS Negl Trop Dis 2020 Dec; 14(12): e0008878.
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2019TRIM8 is required for virus-induced IFN response in human plasmacytoid dendritic cells., Sci Adv. 2019 Nov 20;5(11):eaax3511.
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2019IFN-Stimulated Genes in Zebrafish and Humans Define an Ancient Arsenal of Antiviral Immunity., J. Immunol. 2019 12; 203(12): 3361-3373.
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2019Resident Macrophage Lookalikes of Unexpected Origin, Dev. Cell 2019 May;49(4):501-502.
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2018Fish antiviral tripartite motif (TRIM) proteins, Fish Shellfish Immunol. 2019 Mar;86:724-733.
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2018Single-cell transcriptional analysis reveals ILC-like cells in zebrafish, Sci Immunol 2018 Nov;3(29).
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2018Neutrophils use superoxide to control bacterial infection at a distance, PLoS Pathog. 2018 Jul;14(7):e1007157.
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2018A Model of Superinfection of Virus-Infected Zebrafish Larvae: Increased Susceptibility to Bacteria Associated With Neutrophil Death, Front Immunol 2018;9:1084.
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