Timeline

Jean-Pierre Levraud

Group Leader

01 Jan 2022

publication

Exploring Zebrafish Larvae as a COVID-19 Model: Probable Abortive SARS-CoV-2 Replication in the Swim Bladder.

01 Mar 2021

publication

Mining zebrafish microbiota reveals key community-level resistance against fish pathogen infection.

01 Dec 2020

publication

Spatiotemporal analysis of mycolactone distribution in vivo reveals partial diffusion in the central nervous system.

20 Nov 2019

publication

TRIM8 is required for virus-induced IFN response in human plasmacytoid dendritic cells.

15 Nov 2019

publication

IFN-Stimulated Genes in Zebrafish and Humans Define an Ancient Arsenal of Antiviral Immunity.

20 May 2019

publication

Resident Macrophage Lookalikes of Unexpected Origin

12 Dec 2018

publication

Fish antiviral tripartite motif (TRIM) proteins

16 Nov 2018

publication

Single-cell transcriptional analysis reveals ILC-like cells in zebrafish

17 Jul 2018

publication

Neutrophils use superoxide to control bacterial infection at a distance

24 May 2018

publication

A Model of Superinfection of Virus-Infected Zebrafish Larvae: Increased Susceptibility to Bacteria Associated With Neutrophil Death

06 Jan 2018

project

Molecular Bases of Colonization Resistance

12 Jul 2017

publication

Chikungunya Virus Overcomes Polyamine Depletion by Mutation of nsP1 and the Opal Stop Codon To Confer Enhanced Replication and Fitness

08 Jul 2017

publication

RNase III nucleases from diverse kingdoms serve as antiviral effectors

01 Jul 2017

publication

Imaging of viral neuroinvasion in the zebrafish reveals that Sindbis and chikungunya viruses favour different entry routes.

26 May 2017

publication

FTR83, a Member of the Large Fish-Specific finTRIM Family, Triggers IFN Pathway and Counters Viral Infection.

27 Feb 2017

publication

Specific and Efficient Uptake of Surfactant-Free Poly(Lactic Acid) Nanovaccine Vehicles by Mucosal Dendritic Cells in Adult Zebrafish after Bath Immersion

02 Nov 2016

publication

The Peculiar Characteristics of Fish Type I Interferons

10 Aug 2016

publication

Interferon-Induced Spermidine-Spermine Acetyltransferase and Polyamine Depletion Restrict Zika and Chikungunya Viruses.

21 Dec 2015

publication

Zebrafish Plzf transcription factors enhance early type I IFN response induced by two non-enveloped RNA viruses

17 Jul 2015

tool

Zebrafish facility

16 Jul 2015

team

Group: Response to Infection in the Whole Organism

08 Jul 2015

publication

Identification of polarized macrophage subsets in zebrafish

08 Jun 2015

project

Behaviour of macrophages and neutrophils in vivo

08 Jun 2015

project

Host-virus interactions

11 Feb 2015

publication

Characterization of samhd1 morphant zebrafish recapitulates features of the human type I interferonopathy Aicardi-Goutières syndrome.

01 Jul 2014

publication

Transient infection of the zebrafish notochord with E. coli induces chronic inflammation

25 May 2014

publication

Through the looking glass: witnessing host-virus interplay in zebrafish

15 May 2014

publication

The crystal structure of zebrafish IL-22 reveals an evolutionary, conserved structure highly similar to that of human IL-22

28 Mar 2014

publication

Contrasted innate responses to two viruses in zebrafish: insights into the ancestral repertoire of vertebrate IFN-stimulated genes.

27 Sep 2013

publication

The antiviral innate immune response in fish: evolution and conservation of the IFN system

05 Sep 2013

publication

The zebrafish as a new model for the in vivo study of Shigella flexneri interaction with phagocytes and bacterial autophagy

05 Sep 2013

publication

Real-time whole-body visualization of Chikungunya Virus infection and host interferon response in zebrafish.

03 Jul 2013

publication

Zebrafish ISG15 exerts a strong antiviral activity against RNA and DNA viruses and regulates the interferon response

26 Jul 2012

publication

A new zebrafish model of oro-intestinal pathogen colonization reveals a key role for adhesion in protection by probiotic bacteria

15 Jun 2012

publication

Diversification of IFNγ-inducible CXCb chemokines in cyprinid fish

15 Jul 2011

publication

Origin and evolution of TRIM proteins: new insights from the complete TRIM repertoire of zebrafish and pufferfish

08 Jun 2011

publication

Crystal structure of Zebrafish interferons I and II reveals conservation of type I interferon structure in vertebrates

03 Feb 2011

publication

Whole-body analysis of a viral infection: vascular endothelium is a primary target of infectious hematopoietic necrosis virus in zebrafish larvae.

03 Nov 2010

publication

In vivo analysis of Ifn-γ1 and Ifn-γ2 signaling in zebrafish

01 Sep 2009

publication

Real-time observation of listeria monocytogenes-phagocyte interactions in living zebrafish larvae.

28 Aug 2009

publication

The two groups of zebrafish virus-induced interferons signal via distinct receptors with specific and shared chains

01 Apr 2009

publication

[The immune system of teleost fish]

05 Feb 2009

publication

A large new subset of TRIM genes highly diversified by duplication and positive selection in teleost fish

01 Jan 2008

publication

In vivo analysis of zebrafish innate immunity

17 Sep 2007

publication

Autophagic or necrotic cell death in the absence of caspase and bcl-2 family members

01 Apr 2007

publication

Identification of the zebrafish IFN receptor: implications for the origin of the vertebrate IFN system

01 Jan 2005

publication

Imaging early macrophage differentiation, migration, and behaviors in live zebrafish embryos

17 Dec 2003

publication

Developmental cell death in dictyostelium does not require paracaspase

01 Oct 2003

publication

Cell-death alternative model organisms: why and which?

24 Mar 2003

publication

Dictyostelium cell death: early emergence and demise of highly polarized paddle cells

01 Jan 2001

publication

Methods to study cell death in Dictyostelium discoideum

01 Apr 2000

publication

Characterization and localization of the neonatal Fc receptor in adult human kidney

15 Sep 1999

publication

IL-4-producing gamma delta T cells that express a very restricted TCR repertoire are preferentially localized in liver and spleen

01 Sep 1999

publication

Costimulatory action of glycoinositolphospholipids from Trypanosoma cruzi: increased interleukin 2 secretion and induction of nuclear translocation of the nuclear factor of activated T cells 1

17 May 1999

publication

The composition of a primary T cell response is largely determined by the timing of recruitment of individual T cell clones

01 May 1999

publication

Altered expression of tyrosine kinases of the Src and Syk families in human T-cell leukemia virus type 1-infected T-cell lines

01 Jan 1999

publication

High frequency of specific CD8+ T cells in the tumor and blood is associated with efficient local IL-12 gene therapy of cancer

01 Jul 1998

publication

In vitro induction of specific cytotoxic T lymphocytes using recombinant single-chain MHC class I/peptide complexes

01 Apr 1997

publication

IL-2 gene delivery within an established murine tumor causes its regression without proliferation of preexisting antitumor-specific CTL

01 Feb 1997

publication

A novel subset of adult gamma delta thymocytes that secretes a distinct pattern of cytokines and expresses a very restricted T cell receptor repertoire

01 Apr 1996

publication

The expansion and selection of T cell receptor alpha beta intestinal intraepithelial T cell clones

01 Feb 1996

publication

A little guide for advanced search:

Exploring Zebrafish Larvae as a COVID-19 Model: Probable Abortive SARS-CoV-2 Replication in the Swim Bladder.

Mining zebrafish microbiota reveals key community-level resistance against fish pathogen infection.

Spatiotemporal analysis of mycolactone distribution in vivo reveals partial diffusion in the central nervous system.

TRIM8 is required for virus-induced IFN response in human plasmacytoid dendritic cells.

IFN-Stimulated Genes in Zebrafish and Humans Define an Ancient Arsenal of Antiviral Immunity.

Resident Macrophage Lookalikes of Unexpected Origin

Fish antiviral tripartite motif (TRIM) proteins

Single-cell transcriptional analysis reveals ILC-like cells in zebrafish

Neutrophils use superoxide to control bacterial infection at a distance

A Model of Superinfection of Virus-Infected Zebrafish Larvae: Increased Susceptibility to Bacteria Associated With Neutrophil Death

Molecular Bases of Colonization Resistance

Chikungunya Virus Overcomes Polyamine Depletion by Mutation of nsP1 and the Opal Stop Codon To Confer Enhanced Replication and Fitness

RNase III nucleases from diverse kingdoms serve as antiviral effectors

Imaging of viral neuroinvasion in the zebrafish reveals that Sindbis and chikungunya viruses favour different entry routes.

FTR83, a Member of the Large Fish-Specific finTRIM Family, Triggers IFN Pathway and Counters Viral Infection.

Specific and Efficient Uptake of Surfactant-Free Poly(Lactic Acid) Nanovaccine Vehicles by Mucosal Dendritic Cells in Adult Zebrafish after Bath Immersion

The Peculiar Characteristics of Fish Type I Interferons

Interferon-Induced Spermidine-Spermine Acetyltransferase and Polyamine Depletion Restrict Zika and Chikungunya Viruses.

Zebrafish Plzf transcription factors enhance early type I IFN response induced by two non-enveloped RNA viruses

Zebrafish facility

Group: Response to Infection in the Whole Organism

Identification of polarized macrophage subsets in zebrafish

Behaviour of macrophages and neutrophils in vivo

Host-virus interactions

Characterization of samhd1 morphant zebrafish recapitulates features of the human type I interferonopathy Aicardi-Goutières syndrome.

Transient infection of the zebrafish notochord with E. coli induces chronic inflammation

Through the looking glass: witnessing host-virus interplay in zebrafish

The crystal structure of zebrafish IL-22 reveals an evolutionary, conserved structure highly similar to that of human IL-22

Contrasted innate responses to two viruses in zebrafish: insights into the ancestral repertoire of vertebrate IFN-stimulated genes.

The antiviral innate immune response in fish: evolution and conservation of the IFN system

The zebrafish as a new model for the in vivo study of Shigella flexneri interaction with phagocytes and bacterial autophagy

Real-time whole-body visualization of Chikungunya Virus infection and host interferon response in zebrafish.

Zebrafish ISG15 exerts a strong antiviral activity against RNA and DNA viruses and regulates the interferon response

A new zebrafish model of oro-intestinal pathogen colonization reveals a key role for adhesion in protection by probiotic bacteria

Diversification of IFNγ-inducible CXCb chemokines in cyprinid fish

Origin and evolution of TRIM proteins: new insights from the complete TRIM repertoire of zebrafish and pufferfish

Crystal structure of Zebrafish interferons I and II reveals conservation of type I interferon structure in vertebrates

Whole-body analysis of a viral infection: vascular endothelium is a primary target of infectious hematopoietic necrosis virus in zebrafish larvae.

In vivo analysis of Ifn-γ1 and Ifn-γ2 signaling in zebrafish

Real-time observation of listeria monocytogenes-phagocyte interactions in living zebrafish larvae.

The two groups of zebrafish virus-induced interferons signal via distinct receptors with specific and shared chains

[The immune system of teleost fish]

A large new subset of TRIM genes highly diversified by duplication and positive selection in teleost fish

In vivo analysis of zebrafish innate immunity

Autophagic or necrotic cell death in the absence of caspase and bcl-2 family members

Identification of the zebrafish IFN receptor: implications for the origin of the vertebrate IFN system

Imaging early macrophage differentiation, migration, and behaviors in live zebrafish embryos

Developmental cell death in dictyostelium does not require paracaspase

Cell-death alternative model organisms: why and which?

Dictyostelium cell death: early emergence and demise of highly polarized paddle cells

Methods to study cell death in Dictyostelium discoideum

Characterization and localization of the neonatal Fc receptor in adult human kidney

IL-4-producing gamma delta T cells that express a very restricted TCR repertoire are preferentially localized in liver and spleen

Costimulatory action of glycoinositolphospholipids from Trypanosoma cruzi: increased interleukin 2 secretion and induction of nuclear translocation of the nuclear factor of activated T cells 1

The composition of a primary T cell response is largely determined by the timing of recruitment of individual T cell clones

Altered expression of tyrosine kinases of the Src and Syk families in human T-cell leukemia virus type 1-infected T-cell lines

High frequency of specific CD8+ T cells in the tumor and blood is associated with efficient local IL-12 gene therapy of cancer

In vitro induction of specific cytotoxic T lymphocytes using recombinant single-chain MHC class I/peptide complexes

IL-2 gene delivery within an established murine tumor causes its regression without proliferation of preexisting antitumor-specific CTL

A novel subset of adult gamma delta thymocytes that secretes a distinct pattern of cytokines and expresses a very restricted T cell receptor repertoire

The expansion and selection of T cell receptor alpha beta intestinal intraepithelial T cell clones

Recurrent T cell receptor rearrangements in the cytotoxic T lymphocyte response in vivo against the p815 murine tumor