Timeline

Nadia Naffakh

Head of Structure

12 Jul 2024

event

3rd Drug Discovery & Screening Symposium – “Innovative Therapeutics: Small Molecules and Biologics in Modern Medicine” – an ATC-DDS initiative

30 Apr 2024

publication

The RBPome of influenza A virus NP-mRNA reveals a role for TDP-43 in viral replication.

05 Feb 2024

publication

The host RNA polymerase II C-terminal domain is the anchor for replication of the influenza virus genome.

22 Mar 2023

publication

Design and synthesis of naturally-inspired SARS-CoV-2 inhibitors.

07 Feb 2023

publication

High-throughput droplet-based analysis of influenza A virus genetic reassortment by single-virus RNA sequencing.

23 May 2022

publication

Type B and type A influenza polymerases have evolved distinct binding interfaces to recruit the RNA polymerase II CTD.

01 May 2022

publication

A highly sensitive cell-based luciferase assay for high-throughput automated screening of SARS-CoV-2 nsp5/3CLpro inhibitors.

01 Jan 2021

publication

Single-Cell and Bulk RNA-Sequencing Reveal Differences in Monocyte Susceptibility to Influenza A Virus Infection Between Africans and Europeans.

19 Dec 2018

publication

Advances in Analyzing Virus-Induced Alterations of Host Cell Splicing

03 Sep 2018

project

Trafficking and assembly of influenza virus genomic RNAs

03 Sep 2018

tool

Engineered influenza viruses expressing a tagged polymerase subunit

04 Apr 2018

publication

Mutations Conferring Increased Sensitivity to Tripartite Motif 22 Restriction Accumulated Progressively in the Nucleoprotein of Seasonal Influenza A (H1N1) Viruses between 1918 and 2009

01 Jan 2018

publication

Metal-Tagging Transmission Electron Microscopy and Immunogold Labeling on Tokuyasu Cryosections to Image Influenza A Virus Ribonucleoprotein Transport and Packaging

22 Nov 2017

publication

Comparative Profiling of Ubiquitin Proteasome System Interplay with Influenza A Virus PB2 Polymerase Protein Recapitulating Virus Evolution in Humans

09 Nov 2017

publication

Influenza virus genome reaches the plasma membrane via a modified endoplasmic reticulum and Rab11-dependent vesicles

21 Dec 2016

publication

Structural basis of an essential interaction between influenza polymerase and Pol II CTD

14 Nov 2016

news

SEMINAR OF THE VIROLOGY DEPARTMENT

20 Oct 2016

publication

Genetic Adaptation and Neandertal Admixture Shaped the Immune System of Human Populations

22 Sep 2016

publication

Influenza A Virus Polymerase Recruits the RNA Helicase DDX19 to Promote the Nuclear Export of Viral mRNAs.

09 Aug 2016

publication

Experimental Approaches to Study Genome Packaging of Influenza A Viruses

15 Mar 2016

publication

Time-Resolved Visualisation of Nearly-Native Influenza A Virus Progeny Ribonucleoproteins and Their Individual Components in Live Infected Cells

08 Jan 2016

publication

Targeting host calpain proteases decreases influenza A virus infection

07 Sep 2015

tool

High-throughput protein-protein interaction assay based on a split-luciferase

15 Aug 2015

project

Molecular mechanism of transcription by influenza virus polymerase

16 Jul 2015

team

RNA Biology of Influenza Virus

08 Apr 2015

publication

Temperature-Sensitive Mutants in the Influenza A Virus RNA Polymerase: Alterations in the PA Linker Reduce Nuclear Targeting of the PB1-PA Dimer and Result in Viral Attenuation

12 Jun 2014

publication

Recruitment of RED-SMU1 complex by Influenza A Virus RNA polymerase to control Viral mRNA splicing

02 Apr 2014

publication

Shortening the unstructured, interdomain region of the non-structural protein NS1 of an avian H1N1 influenza virus increases its replication and pathogenicity in chickens

05 Nov 2013

publication

Productive infection of human skeletal muscle cells by pandemic and seasonal influenza A(H1N1) viruses

21 Oct 2013

publication

CD36-specific antibodies block release of HIV-1 from infected primary macrophages and its transmission to T cells

01 Oct 2013

publication

Exploration of binary virus-host interactions using an infectious protein complementation assay.

21 Nov 2012

publication

Synthesis and evaluation of novel 3-C-alkylated-Neu5Ac2en derivatives as probes of influenza virus sialidase 150-loop flexibility.

10 Oct 2012

publication

Influenza A virus progeny vRNP trafficking in live infected cells studied with the virus-encoded fluorescently tagged PB2 protein

06 Jul 2012

publication

The influenza fingerprints: NS1 and M1 proteins contribute to specific host cell ultrastructure signatures upon infection by different influenza A viruses

13 Jun 2012

publication

HMGB1 protein binds to influenza virus nucleoprotein and promotes viral replication

23 Nov 2011

publication

Replication-competent influenza A virus that encodes a split-green fluorescent protein-tagged PB2 polymerase subunit allows live-cell imaging of the virus life cycle

27 Oct 2011

publication

Highly heterogeneous temperature sensitivity of 2009 pandemic influenza A(H1N1) viral isolates, northern France

19 Oct 2011

publication

Length variations in the NA stalk of an H7N1 influenza virus have opposite effects on viral excretion in chickens and ducks

01 Sep 2011

publication

Influenza virus ribonucleoprotein complexes gain preferential access to cellular export machinery through chromatin targeting.

10 Aug 2011

publication

Influenza virus infection induces the nuclear relocalization of the Hsp90 co-chaperone p23 and inhibits the glucocorticoid receptor response.

16 Mar 2011

publication

The influenza A virus NS1 protein interacts with the nucleoprotein of viral ribonucleoprotein complexes

27 Jan 2011

publication

Confronting influenza virus: a common but ever-changing pathogen

01 Sep 2010

publication

In vitro characterization of naturally occurring influenza H3NA- viruses lacking the NA gene segment: toward a new mechanism of viral resistance?

19 Mar 2010

publication

[Interspecies transmission, adaptation to humans and pathogenicity of animal influenza viruses]

04 Nov 2009

publication

A genetically engineered waterfowl influenza virus with a deletion in the stalk of the neuraminidase has increased virulence for chickens

13 May 2009

publication

April 2009: an outbreak of swine-origin influenza A(H1N1) virus with evidence for human-to-human transmission

01 Mar 2007

publication

Codon conservation in the influenza A virus genome defines RNA packaging signals

01 Jan 2007

publication

Failure of zanamivir therapy for pneumonia in a bone-marrow transplant recipient infected by a zanamivir-sensitive influenza A (H1N1) virus.

03 Nov 2005

publication

Recombinant influenza A viruses harboring optimized dicistronic NA segment with an extended native 5′ terminal sequence: induction of heterospecific B and T cell responses in mice

01 Nov 2005

publication

Cloning of the chicken RNA polymerase I promoter and use for reverse genetics of influenza A viruses in avian cells

10 Oct 2005

publication

The generation of recombinant influenza A viruses expressing a PB2 fusion protein requires the conservation of a packaging signal overlapping the coding and noncoding regions at the 5′ end of the PB2 segment

10 May 2004

publication

Binding of the hemagglutinin from human or equine influenza H3 viruses to the receptor is altered by substitutions at residue 193

15 Aug 2003

publication

Expression of a foreign gene by stable recombinant influenza viruses harboring a dicistronic genomic segment with an internal promoter

25 Nov 2002

publication

Differential effect of nucleotide substitutions in the 3′ arm of the influenza A virus vRNA promoter on transcription/replication by avian and human polymerase complexes is related to the nature of PB2 amino acid 627

10 Oct 2001

publication

Hemagglutinin residues of recent human A(H3N2) influenza viruses that contribute to the inability to agglutinate chicken erythrocytes

05 Jul 2001

publication

The transcription/replication activity of the polymerase of influenza A viruses is not correlated with the level of proteolysis induced by the PA subunit

01 Jun 2001

publication

Residue 627 of PB2 is a determinant of cold sensitivity in RNA replication of avian influenza viruses

01 May 2000

publication

Genetic analysis of the compatibility between polymerase proteins from human and avian strains of influenza A viruses

20 Dec 1999

publication

Comparative analysis of the ability of the polymerase complexes of influenza viruses type A, B and C to assemble into functional RNPs that allow expression and replication of heterotypic model RNA templates in vivo

01 Mar 1997

publication

Long-term control of erythropoietin secretion by doxycycline in mice transplanted with engineered primary myoblasts

01 Aug 1996

publication

Gene transfer for erythropoiesis enhancement

01 Jan 1996

publication

Long-term secretion of therapeutic proteins from genetically modified skeletal muscles

11 Apr 1995

publication

Sustained delivery of erythropoietin in mice by genetically modified skin fibroblasts

01 Jan 1995

publication

Delivery of therapeutic proteins from genetically-modified cells

01 Jan 1994

publication

Gene therapy for lysosomal disorders

01 Sep 1993

publication

Transplantation of adult-derived myoblasts in mice following gene transfer

15 Aug 1993

publication

Disappearance of lysosomal storage in spleen and liver of mucopolysaccharidosis VII mice after transplantation of genetically modified bone marrow cells

15 May 1993

publication

Macrophage colony-stimulating factor: serum levels and cDNA structure in malignant osteopetrosis

01 Jan 1991

publication

A little guide for advanced search:

3rd Drug Discovery & Screening Symposium – “Innovative Therapeutics: Small Molecules and Biologics in Modern Medicine” – an ATC-DDS initiative

The RBPome of influenza A virus NP-mRNA reveals a role for TDP-43 in viral replication.

The host RNA polymerase II C-terminal domain is the anchor for replication of the influenza virus genome.

Design and synthesis of naturally-inspired SARS-CoV-2 inhibitors.

High-throughput droplet-based analysis of influenza A virus genetic reassortment by single-virus RNA sequencing.

Type B and type A influenza polymerases have evolved distinct binding interfaces to recruit the RNA polymerase II CTD.

A highly sensitive cell-based luciferase assay for high-throughput automated screening of SARS-CoV-2 nsp5/3CLpro inhibitors.

Single-Cell and Bulk RNA-Sequencing Reveal Differences in Monocyte Susceptibility to Influenza A Virus Infection Between Africans and Europeans.

Advances in Analyzing Virus-Induced Alterations of Host Cell Splicing

Trafficking and assembly of influenza virus genomic RNAs

Engineered influenza viruses expressing a tagged polymerase subunit

Mutations Conferring Increased Sensitivity to Tripartite Motif 22 Restriction Accumulated Progressively in the Nucleoprotein of Seasonal Influenza A (H1N1) Viruses between 1918 and 2009

Metal-Tagging Transmission Electron Microscopy and Immunogold Labeling on Tokuyasu Cryosections to Image Influenza A Virus Ribonucleoprotein Transport and Packaging

Comparative Profiling of Ubiquitin Proteasome System Interplay with Influenza A Virus PB2 Polymerase Protein Recapitulating Virus Evolution in Humans

Influenza virus genome reaches the plasma membrane via a modified endoplasmic reticulum and Rab11-dependent vesicles

Structural basis of an essential interaction between influenza polymerase and Pol II CTD

SEMINAR OF THE VIROLOGY DEPARTMENT

Genetic Adaptation and Neandertal Admixture Shaped the Immune System of Human Populations

Influenza A Virus Polymerase Recruits the RNA Helicase DDX19 to Promote the Nuclear Export of Viral mRNAs.

Experimental Approaches to Study Genome Packaging of Influenza A Viruses

Time-Resolved Visualisation of Nearly-Native Influenza A Virus Progeny Ribonucleoproteins and Their Individual Components in Live Infected Cells

Targeting host calpain proteases decreases influenza A virus infection

High-throughput protein-protein interaction assay based on a split-luciferase

Molecular mechanism of transcription by influenza virus polymerase

RNA Biology of Influenza Virus

Temperature-Sensitive Mutants in the Influenza A Virus RNA Polymerase: Alterations in the PA Linker Reduce Nuclear Targeting of the PB1-PA Dimer and Result in Viral Attenuation

Recruitment of RED-SMU1 complex by Influenza A Virus RNA polymerase to control Viral mRNA splicing

Shortening the unstructured, interdomain region of the non-structural protein NS1 of an avian H1N1 influenza virus increases its replication and pathogenicity in chickens

Productive infection of human skeletal muscle cells by pandemic and seasonal influenza A(H1N1) viruses

CD36-specific antibodies block release of HIV-1 from infected primary macrophages and its transmission to T cells

Exploration of binary virus-host interactions using an infectious protein complementation assay.

Synthesis and evaluation of novel 3-C-alkylated-Neu5Ac2en derivatives as probes of influenza virus sialidase 150-loop flexibility.

Influenza A virus progeny vRNP trafficking in live infected cells studied with the virus-encoded fluorescently tagged PB2 protein

The influenza fingerprints: NS1 and M1 proteins contribute to specific host cell ultrastructure signatures upon infection by different influenza A viruses

HMGB1 protein binds to influenza virus nucleoprotein and promotes viral replication

Replication-competent influenza A virus that encodes a split-green fluorescent protein-tagged PB2 polymerase subunit allows live-cell imaging of the virus life cycle

Highly heterogeneous temperature sensitivity of 2009 pandemic influenza A(H1N1) viral isolates, northern France

Length variations in the NA stalk of an H7N1 influenza virus have opposite effects on viral excretion in chickens and ducks

Influenza virus ribonucleoprotein complexes gain preferential access to cellular export machinery through chromatin targeting.

Influenza virus infection induces the nuclear relocalization of the Hsp90 co-chaperone p23 and inhibits the glucocorticoid receptor response.

The influenza A virus NS1 protein interacts with the nucleoprotein of viral ribonucleoprotein complexes

Confronting influenza virus: a common but ever-changing pathogen

In vitro characterization of naturally occurring influenza H3NA- viruses lacking the NA gene segment: toward a new mechanism of viral resistance?

[Interspecies transmission, adaptation to humans and pathogenicity of animal influenza viruses]

A genetically engineered waterfowl influenza virus with a deletion in the stalk of the neuraminidase has increased virulence for chickens

April 2009: an outbreak of swine-origin influenza A(H1N1) virus with evidence for human-to-human transmission

Codon conservation in the influenza A virus genome defines RNA packaging signals

Failure of zanamivir therapy for pneumonia in a bone-marrow transplant recipient infected by a zanamivir-sensitive influenza A (H1N1) virus.

Recombinant influenza A viruses harboring optimized dicistronic NA segment with an extended native 5′ terminal sequence: induction of heterospecific B and T cell responses in mice

Cloning of the chicken RNA polymerase I promoter and use for reverse genetics of influenza A viruses in avian cells

The generation of recombinant influenza A viruses expressing a PB2 fusion protein requires the conservation of a packaging signal overlapping the coding and noncoding regions at the 5′ end of the PB2 segment

Binding of the hemagglutinin from human or equine influenza H3 viruses to the receptor is altered by substitutions at residue 193

Expression of a foreign gene by stable recombinant influenza viruses harboring a dicistronic genomic segment with an internal promoter

Differential effect of nucleotide substitutions in the 3′ arm of the influenza A virus vRNA promoter on transcription/replication by avian and human polymerase complexes is related to the nature of PB2 amino acid 627

Hemagglutinin residues of recent human A(H3N2) influenza viruses that contribute to the inability to agglutinate chicken erythrocytes

The transcription/replication activity of the polymerase of influenza A viruses is not correlated with the level of proteolysis induced by the PA subunit

Residue 627 of PB2 is a determinant of cold sensitivity in RNA replication of avian influenza viruses

Genetic analysis of the compatibility between polymerase proteins from human and avian strains of influenza A viruses

Comparative analysis of the ability of the polymerase complexes of influenza viruses type A, B and C to assemble into functional RNPs that allow expression and replication of heterotypic model RNA templates in vivo

Long-term control of erythropoietin secretion by doxycycline in mice transplanted with engineered primary myoblasts

Gene transfer for erythropoiesis enhancement

Long-term secretion of therapeutic proteins from genetically modified skeletal muscles

Sustained delivery of erythropoietin in mice by genetically modified skin fibroblasts

Delivery of therapeutic proteins from genetically-modified cells

Gene therapy for lysosomal disorders

Transplantation of adult-derived myoblasts in mice following gene transfer

Disappearance of lysosomal storage in spleen and liver of mucopolysaccharidosis VII mice after transplantation of genetically modified bone marrow cells

Macrophage colony-stimulating factor: serum levels and cDNA structure in malignant osteopetrosis

Gene transfer to somatic tissues using retroviral vectors